stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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pmid:9608395 | ||||
Luo L et al. | Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. | 2007 | AAPS J | pmid:18170979 |
Kuppuswamy R et al. | Estimation of capping incidence by indentation fracture tests. | 2001 | AAPS PharmSci | pmid:11741256 |
Otsuka M et al. | Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process. | 2001 | AAPS PharmSci | pmid:11741271 |
Missaghi S and Fassihi R | A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. | 2004 | AAPS PharmSciTech | pmid:15760087 |
Swaminathan V and Kildsig DO | Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. | 2002 | AAPS PharmSciTech | pmid:12916934 |
Gupta A et al. | Difference in the lubrication efficiency of bovine and vegetable-derived magnesium stearate during tabletting. | 2009 | AAPS PharmSciTech | pmid:19390976 |
Zhou QT et al. | Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. | 2013 | AAPS PharmSciTech | pmid:23196863 |
Mir VG et al. | Application of crustacean chitin as a co-diluent in direct compression of tablets. | 2010 | AAPS PharmSciTech | pmid:20238188 |
Shidhaye SS et al. | Buccal drug delivery of pravastatin sodium. | 2010 | AAPS PharmSciTech | pmid:20300898 |
Räsänen E et al. | A new method to predict flowability using a microscale fluid bed. | 2003 | AAPS PharmSciTech | pmid:15198548 |
Waters LJ et al. | Controlled microwave processing applied to the pharmaceutical formulation of ibuprofen. | 2011 | AAPS PharmSciTech | pmid:21842309 |
Khan FN and Dehghan MH | Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. | 2011 | AAPS PharmSciTech | pmid:21879394 |
Fernández EG et al. | Rapid development and optimization of tablet manufacturing using statistical tools. | 2008 | AAPS PharmSciTech | pmid:18459048 |
Chang CK et al. | Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc. | 2008 | AAPS PharmSciTech | pmid:18459052 |
Lau M et al. | Investigation into the Manufacture and Properties of Inhalable High-Dose Dry Powders Produced by Comilling API and Lactose with Magnesium Stearate. | 2017 | AAPS PharmSciTech | pmid:28070849 |
Kelidari HR et al. | Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. | 2017 | AAPS PharmSciTech | pmid:27834054 |
Monajjemzadeh F et al. | Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies. | 2009 | AAPS PharmSciTech | pmid:19455427 |
Schrank S et al. | Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. | 2012 | AAPS PharmSciTech | pmid:22552931 |