| MeSH term | MeSH ID | Detail |
|---|---|---|
| Eczema, Dyshidrotic | D011146 | 1 associated lipids |
| Decalcification, Pathologic | D003649 | 1 associated lipids |
| Salivary Duct Calculi | D012465 | 2 associated lipids |
| Anemia, Dyserythropoietic, Congenital | D000742 | 2 associated lipids |
| Relapsing Fever | D012061 | 3 associated lipids |
| Tenosynovitis | D013717 | 3 associated lipids |
| Infertility | D007246 | 3 associated lipids |
| Obesity, Abdominal | D056128 | 3 associated lipids |
| Syphilis, Congenital | D013590 | 3 associated lipids |
| Hypothalamic Diseases | D007027 | 3 associated lipids |
| Pneumoconiosis | D011009 | 3 associated lipids |
| Gallbladder Neoplasms | D005706 | 3 associated lipids |
| Calculi | D002137 | 3 associated lipids |
| Legionnaires' Disease | D007877 | 4 associated lipids |
| Chancroid | D002602 | 4 associated lipids |
| Yaws | D015001 | 4 associated lipids |
| Syphilis, Latent | D013592 | 4 associated lipids |
| Leukodystrophy, Metachromatic | D007966 | 4 associated lipids |
| Prostatic Diseases | D011469 | 4 associated lipids |
| Boutonneuse Fever | D001907 | 5 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mashek DG and Grummer RR | Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. | 2003 | J. Dairy Sci. | pmid:12906057 |
| Giesy JG et al. | Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation holstein cows. | 2002 | J. Dairy Sci. | pmid:12214995 |
| Moate PJ et al. | Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. | 2008 | J. Dairy Sci. | pmid:18292274 |
| Rukkwamsuk T et al. | Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum. | 2000 | J. Dairy Sci. | pmid:10659963 |
| Piantoni P et al. | Milk production responses to dietary stearic acid vary by production level in dairy cattle. | 2015 | J. Dairy Sci. | pmid:25529423 |
| Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
| Honkanen AM et al. | Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. | 2012 | J. Dairy Sci. | pmid:22365221 |
| AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
| Yang YT et al. | Dietary lipid metabolism in lactating dairy cows. | 1978 | J. Dairy Sci. | pmid:568635 |
| Loften JR et al. | Invited review: palmitic and stearic acid metabolism in lactating dairy cows. | 2014 | J. Dairy Sci. | pmid:24913651 |
| Fellner V et al. | Effect of nigericin, monensin, and tetronasin on biohydrogenation in continuous flow-through ruminal fermenters. | 1997 | J. Dairy Sci. | pmid:9178132 |
| Rico JE et al. | Compared with stearic acid, palmitic acid increased the yield of milk fat and improved feed efficiency across production level of cows. | 2014 | J. Dairy Sci. | pmid:24342689 |
| Enjalbert F et al. | Effects of duodenal infusions of palmitic, stearic, or oleic acids on milk composition and physical properties of butter. | 2000 | J. Dairy Sci. | pmid:10908048 |
| Anderson RR et al. | Composition of cottontail rabbit milk from stomachs of young and directly from gland. | 1975 | J. Dairy Sci. | pmid:1184805 |
| Jenkins TC | Feeding oleamide to lactating Jersey cows 1. Effects on lactation performance and milk fatty acid composition. | 2000 | J. Dairy Sci. | pmid:10714869 |
| Lai HC et al. | Alteration of plasma lipids in the rat by fractionation of modified milk fat (butterfat). | 1995 | J. Dairy Sci. | pmid:7790571 |
| Fukuda S et al. | Augmentation of vaccenate production and suppression of vaccenate biohydrogenation in cultures of mixed ruminal microbes. | 2006 | J. Dairy Sci. | pmid:16507700 |
| Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
| Contreras GA et al. | Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids. | 2010 | J. Dairy Sci. | pmid:20494158 |
| Aardema H et al. | Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. | 2015 | J. Dairy Sci. | pmid:25648816 |
| DePeters EJ et al. | Fatty acid and triglyceride composition of milk fat from lactating Holstein cows in response to supplemental canola oil. | 2001 | J. Dairy Sci. | pmid:11352169 |
| Rukkwamsuk T et al. | Hepatic fatty acid composition in periparturient dairy cows with fatty liver induced by intake of a high energy diet in the dry period. | 1999 | J. Dairy Sci. | pmid:10068949 |
| Perfield JW et al. | Effects of amide-protected and lipid-encapsulated conjugated linoleic acid supplements on milk fat synthesis. | 2004 | J. Dairy Sci. | pmid:15375062 |
| Chalupa W et al. | Ruminal fermentation in vivo as influenced by long-chain fatty acids. | 1986 | J. Dairy Sci. | pmid:3722545 |
| Yonezawa T et al. | Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells. | 2004 | J. Dairy Sci. | pmid:15328276 |
| Sharma BK and Erdman RA | In vitro degradation of choline from selected feedstuffs and choline supplements. | 1989 | J. Dairy Sci. | pmid:2600236 |
| Maduko CO et al. | Enzymatic interesterification of tripalmitin with vegetable oil blends for formulation of caprine milk infant formula analogs. | 2007 | J. Dairy Sci. | pmid:17235135 |
| Graves EL et al. | Factors affecting the concentration of sphingomyelin in bovine milk. | 2007 | J. Dairy Sci. | pmid:17235147 |
| Mosley SA et al. | Effect of varying levels of fatty acids from palm oil on feed intake and milk production in Holstein cows. | 2007 | J. Dairy Sci. | pmid:17235176 |
| BOYD EN et al. | IRRELATION OF KETO STEARIC ACIDS TO FATTY ACID METABOLISM IN THE RUMINANT MAMMARY GLAND. | 1965 | J. Dairy Sci. | pmid:14292229 |
| Sklan D et al. | Digestion and absorption of lipids and bile acids in sheep fed stearic acid, oleic acid, or tristearin. | 1985 | J. Dairy Sci. | pmid:4031186 |
| Forsberg NE et al. | Roles of acetate and its interactions with glucose and lactate in cow mammary tissue. | 1984 | J. Dairy Sci. | pmid:6438200 |
| White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
| Toral PG et al. | Does supplemental 18:0 alleviate fish oil-induced milk fat depression in dairy ewes? | 2016 | J. Dairy Sci. | pmid:26627853 |
| Kushibiki S et al. | Effect of beta-lactoglobulin on plasma retinol and triglyceride concentrations, and fatty acid composition in calves. | 2001 | J. Dairy Res. | pmid:11928954 |
| Sevi A et al. | Rumen-protected methionine or lysine supplementation of Comisana ewes' diets: effects on milk fatty acid composition. | 1998 | J. Dairy Res. | pmid:9718494 |
| Cosenza G et al. | A novel polymorphism in the oxytocin receptor encoding gene (OXTR) affects milk fatty acid composition in Italian Mediterranean river buffalo. | 2017 | J. Dairy Res. | pmid:28524009 |
| Price ER et al. | Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21153644 |
| Chapple IL et al. | Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. | 2012 | J. Clin. Periodontol. | pmid:22093005 |
| Velegraki A et al. | Use of fatty acid RPMI 1640 media for testing susceptibilities of eight Malassezia species to the new triazole posaconazole and to six established antifungal agents by a modified NCCLS M27-A2 microdilution method and Etest. | 2004 | J. Clin. Microbiol. | pmid:15297502 |
| Shepherd J et al. | Effects of dietary polyunsaturated and saturated fat on the properties of high density lipoproteins and the metabolism of apolipoprotein A-I. | 1978 | J. Clin. Invest. | pmid:207739 |
| Gozes I and Fridkin M | A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model. | 1992 | J. Clin. Invest. | pmid:1522236 |
| Dentin R et al. | Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. | 2005 | J. Clin. Invest. | pmid:16184193 |
| Moore KH et al. | beta-Hydroxy fatty acid production by ischemic rabbit heart. | 1982 | J. Clin. Invest. | pmid:6799549 |
| Mansbach CM | The origin of chylomicron phosphatidylcholine in the rat. | 1977 | J. Clin. Invest. | pmid:874099 |
| Craven PA et al. | Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis. | 1980 | J. Clin. Invest. | pmid:6243313 |
| Nossel HL et al. | Inhibition of collagen-induced platelet aggregation by normal plasma. | 1971 | J. Clin. Invest. | pmid:4107268 |
| Neufeld EJ et al. | High affinity esterification of eicosanoid precursor fatty acids by platelets. | 1983 | J. Clin. Invest. | pmid:6308046 |
| Heyman SN et al. | Erythromycin-induced dynamic ileus? | 1988 | J. Clin. Gastroenterol. | pmid:3183328 |
| Biesalski HK and Weiser H | Sensitive analysis of retinyl esters by isocratic adsorption chromatography. | 1989 | J. Clin. Chem. Clin. Biochem. | pmid:2746165 |
| Su C et al. | A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20732836 |
| MORRIS LJ | SEPARATION OF ISOMERIC LONG-CHAIN POLYHYDROXY ACIDS BY THIN-LAYER CHROMATOGRAPHY. | 1963 | J. Chromatogr. | pmid:14070998 |
| Vilim A et al. | A simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate and ethylsuccinate. | 1977 | J. Chromatogr. | pmid:838805 |
| Graham KC et al. | Simple thin-layer chromatographic identification method for erythromycin stearate. | 1976 | J. Chromatogr. | pmid:977688 |
| DOBBS HE | THE USE OF A WINDOWLESS GAS-FLOW COUNTER FOR DETECTING WEAK BETA EMITTERS ON PAPER CHROMATOGRAMS. | 1964 | J. Chromatogr. | pmid:14194371 |
| SUBBARAM MR | SEPARATION OF SATURATED AND UNSATURATED FATTY ACID ESTERS OF CHOLESTEROL BY GAS-LIQUID CHROMATOGRAPHY. | 1964 | J. Chromatogr. | pmid:14194379 |
| BERGELSON LD et al. | COMPLETE STRUCTURAL ANALYSIS OF FATTY ACID MIXTURES BY THIN-LAYER CHROMATOGRAPHY. | 1964 | J. Chromatogr. | pmid:14205937 |
| HAMMONDS TW and SHONE G | THE SEPARATION OF FATTY ACID METHYL ESTERS (INCLUDING "CRITICAL PAIRS") BY THIN-LAYER PARTITION CHROMATOGRAPHY. | 1964 | J. Chromatogr. | pmid:14205938 |
| BERGMANN ED et al. | THIN-LAYER CHROMATOGRAPHY OF BETA-SITOSTERYL ESTERS. | 1964 | J. Chromatogr. | pmid:14207024 |
| Tan S et al. | Gas chromatographic determination of calcium stearate in polyethylene food packaging sheets. | 1988 | J. Chromatogr. | pmid:3209663 |
| Kaplan E and Ansari K | High-performance liquid chromatography as a tool for identification of linolenic acid hydroperoxide prepared with soybean lipoxygenase. | 1985 | J. Chromatogr. | pmid:3937844 |
| EDWARDS CH et al. | CHROMATOGRAPHY ON COMPOUNDS OF BIOLOGICAL INTEREST OF GLASS FIBER, PARAFFIN-COATED, AND UNTREATED CELLULOSE PAPER. | 1963 | J. Chromatogr. | pmid:14045492 |
| Musty PR and Nickless G | Extractants for organochlorine insecticides and polychlorinated biphenyls from water. | 1976 | J. Chromatogr. | pmid:818099 |
| BADINGS HT | THIN-LAYER CHROMATOGRAPHY UNDER CONTROLLED CONDITIONS. | 1964 | J. Chromatogr. | pmid:14165965 |
| Smuts CM and Tichelaar HY | Simple thin-layer chromatographic purification procedure for the determination of cholesterol ester fatty acid compositions. | 1991 | J. Chromatogr. | pmid:1860921 |
| Snoeren TA et al. | Multidisciplinary approach to unravelling the relative contribution of different oxylipins in indirect defense of Arabidopsis thaliana. | 2009 | J. Chem. Ecol. | pmid:19798534 |
| Hirabara SM et al. | Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. | 2010 | J. Cell. Physiol. | pmid:19780047 |
| Elbaz A et al. | Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. | 2010 | J. Cell. Mol. Med. | pmid:19382912 |
| Thörn K and Bergsten P | Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate. | 2010 | J. Cell. Biochem. | pmid:20524206 |
| Hoover RL et al. | Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. | 1983 | J. Cell Biol. | pmid:6223042 |
| Frohlich BT et al. | Formation and cell-medium partitioning of autoinhibitory free fatty acids and cyclodextrin's effect in the cultivation of Bordetella pertussis. | 1996 | J. Biotechnol. | pmid:9147447 |
| Ramstedt M et al. | Wet chemical silver treatment of endotracheal tubes to produce antibacterial surfaces. | 2007 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:17385236 |
| Willie BM et al. | Possible explanation for the white band artifact seen in clinically retrieved polyethylene tibial components. | 2000 | J. Biomed. Mater. Res. | pmid:11007625 |
| Willie BM et al. | Elemental and morphological identification of third-body particulate and calcium stearate inclusions in polyethylene components. | 2000 | J. Biomed. Mater. Res. | pmid:10713559 |
| Pitt WG and Cooper SL | Albumin adsorption on alkyl chain derivatized polyurethanes: I. The effect of C-18 alkylation. | 1988 | J. Biomed. Mater. Res. | pmid:3397377 |
| Mungur R et al. | Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene. | 2005 | J. Biomed. Biotechnol. | pmid:16046826 |
| Kouskoumvekaki I and Panagiotou G | Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules. | 2011 | J. Biomed. Biotechnol. | pmid:20936122 |
| Tammaro A et al. | Magnesium stearate: an underestimated allergen. | 2012 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:23241129 |
| Chien JL and Hogan EL | Novel pentahexosyl ganglioside of the globo series purified from chicken muscle. | 1983 | J. Biol. Chem. | pmid:6885798 |
| Muszbek L and Laposata M | Myristoylation of proteins in platelets occurs predominantly through thioester linkages. | 1993 | J. Biol. Chem. | pmid:8463334 |
| Ting TC et al. | Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. | 2011 | J. Biol. Chem. | pmid:21596756 |
| CONIGLIO JG and CATE DL | The distribution and biosynthesis of palmitic and stearic acids in liver, intestine, and carcass of intact normal and fasted rats. | 1958 | J. Biol. Chem. | pmid:13549425 |
| Sampath H et al. | Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. | 2007 | J. Biol. Chem. | pmid:17127673 |
| Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
| Vitturi DA et al. | Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. | 2013 | J. Biol. Chem. | pmid:23878198 |
| Slomiany A et al. | Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients. | 1983 | J. Biol. Chem. | pmid:6863300 |
| Doering TL et al. | Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. | 1993 | J. Biol. Chem. | pmid:8486622 |
| Moehren G et al. | Activation and desensitization of phospholipase D in intact rat hepatocytes. | 1994 | J. Biol. Chem. | pmid:8288637 |
| Christian F et al. | Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. | 2011 | J. Biol. Chem. | pmid:21177871 |
| Hsia JC and Kwan NH | Human serum albumin: binding specificity and allosteric effect of parinarate and stearate. A dianionic spin label study. | 1981 | J. Biol. Chem. | pmid:6257712 |
| Luhrs CA and Slomiany BL | A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. | 1989 | J. Biol. Chem. | pmid:2557328 |
| Wang G et al. | Phosphatidylcholines with sn-1 saturated and sn-2 cis-monounsaturated acyl chains. Their melting behavior and structures. | 1995 | J. Biol. Chem. | pmid:7559399 |
| TIETZ A et al. | A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS. | 1964 | J. Biol. Chem. | pmid:14247652 |
| BJOERNTORP P et al. | ALBUMIN ANTAGONISM OF FATTY ACID EFFECTS ON OXIDATION AND PHOSPHORYLATION REACTIONS IN RAT LIVER MITOCHONDRIA. | 1964 | J. Biol. Chem. | pmid:14114863 |
| BENJAMIN W and GELLHORN A | THE EFFECT OF DIABETES AND INSULIN ON THE BIOSYNTHESIS OF INDIVIDUAL FATTY ACIDS IN ADIPOSE TISSUE. | 1964 | J. Biol. Chem. | pmid:14114873 |
| LEVIS GM and MEAD JF | AN ALPHA-HYDROXY ACID DECARBOXYLASE IN BRAIN MICROSOMES. | 1964 | J. Biol. Chem. | pmid:14114875 |
| FUTTERMAN S and ANDREWS JS | METABOLISM OF THE RETINA. IV. THE COMPOSITION OF VITAMIN A ESTER SYNTHESIZED BY THE RETINA. | 1964 | J. Biol. Chem. | pmid:14114876 |
| PREISS B and BLOCH K | OMEGA-OXIDATION OF LONG CHAIN FATTY ACIDS IN RAT LIVER. | 1964 | J. Biol. Chem. | pmid:14114877 |
| Larner JM et al. | The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. | 1993 | J. Biol. Chem. | pmid:8314757 |
| Agrawal HC et al. | In vivo incorporation of [3H]palmitic acid into PO protein, the major intrinsic protein of rat sciatic nerve myelin. | 1983 | J. Biol. Chem. | pmid:6189827 |