stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Burns D002056 34 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Neoplasms D008113 8 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Sylvester PW et al. Effects of specific fatty acids on prolactin-induced NB2 lymphoma cell proliferation. 1993 Life Sci. pmid:8505862
Sastri MS et al. In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. 1993 Arzneimittelforschung pmid:8489559
Mustad VA et al. Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. 1993 Metab. Clin. Exp. pmid:8487669
Doering TL et al. Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. 1993 J. Biol. Chem. pmid:8486622
Woldseth B et al. Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. 1993 Biochim. Biophys. Acta pmid:8481391
el-Sharkawy SH et al. Microbiological transformations of lipids: acyl-specific hydrolysis of lard by yeasts. 1993 Appl. Environ. Microbiol. pmid:8480999
Michiels C et al. Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. 1993 Am. J. Physiol. pmid:8476019
Mensink RP Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. 1993 Am. J. Clin. Nutr. pmid:8475888
Hari PR and Sharma CP Protein adsorption--effect of external lubricants at the interface. 1993 J Biomater Appl pmid:8473987
Hamilton KS et al. Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. 1993 Biochemistry pmid:8471610
Nishihira J et al. Identification of the hydrophobic ligand-binding region in recombinant glutathione S-transferase P and its binding effect on the conformational state of the enzyme. 1993 Arch. Biochem. Biophys. pmid:8470890
Muszbek L and Laposata M Myristoylation of proteins in platelets occurs predominantly through thioester linkages. 1993 J. Biol. Chem. pmid:8463334
Derr J et al. The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: II. The plasma total and low-density lipoprotein cholesterol response of individual fatty acids. 1993 Metab. Clin. Exp. pmid:8446040
Poulos A et al. Fatty acid synthesis from [2-14C]acetate in normal and peroxisome-deficient (Zellweger) fibroblasts. 1993 Lipids pmid:8441343
Das T et al. Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. 1993 Eur. J. Biochem. pmid:8436130
Callaghan R et al. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. 1993 Biochim. Biophys. Acta pmid:8435444
Baer HH and Wu X Synthesis of alpha,alpha-trehalose 2,3- and 2,3'-diesters with palmitic and stearic acid: potential immunoreactants for the serodiagnosis of tuberculosis. 1993 Carbohydr. Res. pmid:8431934
Wada H et al. In vitro ferredoxin-dependent desaturation of fatty acids in cyanobacterial thylakoid membranes. 1993 J. Bacteriol. pmid:8419301
Imaizumi K et al. Fat containing stearic acid increases fecal neutral steroid excretion and catabolism of low density lipoproteins without affecting plasma cholesterol concentration in hamsters fed a cholesterol-containing diet. 1993 J. Nutr. pmid:8410360
Emken EA et al. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. 1993 Biochim. Biophys. Acta pmid:8399342
Viswanathan R et al. Strained-layer van der Waals epitaxy in a Langmuir-Blodgett film. 1993 Science pmid:8392751
Vilim A et al. A simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate and ethylsuccinate. 1977 J. Chromatogr. pmid:838805
Raines DE and Miller KW The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. 1993 Biophys. J. pmid:8386010
Cisar LA et al. Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts. 1993 Cell. Signal. pmid:8373725
Zock PL et al. Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. 1993 Eur J Clin Nutr pmid:8365385
Lurie E et al. N-(2-hydroxybenzyl)-omega-amino carbonic acids and their derivatives as tools for biochemical and biophysical investigations. 1993 Biochem. Mol. Biol. Int. pmid:8358340
Monsma CC and Ney DM Interrelationship of stearic acid content and triacylglycerol composition of lard, beef tallow and cocoa butter in rats. 1993 Lipids pmid:8355579
Muriana FJ et al. Lipid and fatty acid composition of hepatopancreatic brush-border membrane vesicles from the prawn Penaeus japonicus. 1993 J. Biochem. pmid:8340355
Patil GS and Cornwell DG Surface phase separation and collapse of the stearate anion--alkaline earth cation complex. 1977 J. Lipid Res. pmid:833501
Rich MR Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. 1993 Biochim. Biophys. Acta pmid:8329458
Tetzloff SU and Bizzozero OA Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids. 1993 Biochem. Biophys. Res. Commun. pmid:8323550
Larner JM et al. The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. 1993 J. Biol. Chem. pmid:8314757
Tholstrup T et al. Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. 1994 Am. J. Clin. Nutr. pmid:8310987
Mitropoulos KA et al. Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. 1994 Arterioscler. Thromb. pmid:8305411
Croxtall JD et al. Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. 1994 Biochem. Pharmacol. pmid:8304964
Moehren G et al. Activation and desensitization of phospholipase D in intact rat hepatocytes. 1994 J. Biol. Chem. pmid:8288637
Hrelia S et al. In vivo effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositols in resting and anti-CD3-activated lymphocytes. 1993 Alcohol. Clin. Exp. Res. pmid:8279665
Sullivan JL et al. Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. 1993 J. Dairy Sci. pmid:8270698
Koroly MJ and Conner RL Unsaturated fatty acid biosynthesis in Tetrahymena. Evidence for two pathways. 1976 J. Biol. Chem. pmid:826532
Ramanadham S et al. Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. 1993 Biochemistry pmid:8257685
Visioli F et al. Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation. 1993 J. Neurochem. pmid:8228997
Samochocki M and Strosznajder J Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranes. 1993 Neurochem. Int. pmid:8220171
Lee WN et al. In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. 1994 Am. J. Physiol. pmid:8203508
Doering TL et al. The fatty acids in unremodelled trypanosome glycosyl-phosphatidylinositols. 1994 Biochem. J. pmid:8192662
Batten TL et al. Contact dermatitis from the old formula E45 cream. 1994 Contact Derm. pmid:8187515
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Lu B et al. Characterization of modified staphylococcal protein A containing phospholipid monolayer on both solution and slide surfaces. 1994 Biochem. Biophys. Res. Commun. pmid:8185601
Chigorno V et al. Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-14C]palmitic acid and [1-14C]stearic acid to rat cerebellar granule cells in culture. 1994 Eur. J. Biochem. pmid:8181467
Musty PR and Nickless G Extractants for organochlorine insecticides and polychlorinated biphenyls from water. 1976 J. Chromatogr. pmid:818099
Hyson DA et al. Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits. 1994 Lipids pmid:8177021