stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Anderson EK et al. | Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22556332 |
Prashanth KN and Basavaiah K | Sensitive spectrophotometric determination of atenolol in pharmaceutical formulations using bromate-bromide mixture as an eco-friendly brominating agent. | 2012 | J Anal Methods Chem | pmid:22567567 |
de Souza Monteiro A et al. | Bioconversion of biodiesel refinery waste in the bioemulsifier by Trichosporon mycotoxinivorans CLA2. | 2012 | Biotechnol Biofuels | pmid:22559210 |
Yang P et al. | Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. | 2012 | PLoS ONE | pmid:22536429 |
Nagpal M et al. | Formulation development and evaluation of alginate microspheres of Ibuprofen. | 2012 | J Young Pharm | pmid:22523454 |
Vijay J et al. | Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. | 2012 | J Young Pharm | pmid:22523453 |
Baratta F et al. | Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity. | 2012 | Croat. Med. J. | pmid:22522996 |
Kwon Y et al. | Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. | 2012 | Int J Mol Sci | pmid:22489147 |
Quintela M et al. | Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography. | 2012 | J Chromatogr A | pmid:22227361 |
Schaab M et al. | Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. | 2012 | PLoS ONE | pmid:22545089 |
Ghadiri M et al. | Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size. | 2012 | Int J Pharm | pmid:22227603 |
Kim S et al. | Lipid-binding properties of TRIM72. | 2012 | BMB Rep | pmid:22281009 |
Borbon IA et al. | Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. | 2012 | Pharmacol. Biochem. Behav. | pmid:22202649 |
El-Enany NM et al. | Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma. | 2012 | Chem Cent J | pmid:22277722 |
Scalia S et al. | Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. | 2012 | J Microencapsul | pmid:22208706 |
Anton N et al. | A new application of lipid nanoemulsions as coating agent, providing zero-order hydrophilic drug release from tablets. | 2012 | J Drug Deliv | pmid:22272376 |
Duong CT and Roper MG | A microfluidic device for the automated derivatization of free fatty acids to fatty acid methyl esters. | 2012 | Analyst | pmid:22166918 |
Zhen Z and Xie J | Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging. | 2012 | Theranostics | pmid:22272218 |
Imae R et al. | LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. | 2012 | J. Lipid Res. | pmid:22172515 |
Becker S et al. | Optimization of hepatocarcinoma uptake with radiolabeled lipiodol: development of new lipiodol formulations with increased viscosity. | 2012 | Cancer Biother. Radiopharm. | pmid:22149684 |
Streit MR et al. | High survival in young patients using a second generation uncemented total hip replacement. | 2012 | Int Orthop | pmid:22113735 |
Pijls BG et al. | Polyethylene thickness is a risk factor for wear necessitating insert exchange. | 2012 | Int Orthop | pmid:22105569 |
Chapple IL et al. | Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. | 2012 | J. Clin. Periodontol. | pmid:22093005 |
Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
Imarisio C et al. | Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. | 2012 | Clin. Sci. | pmid:22439844 |
Rojas J and Kumar V | Effect of silicification on the tableting performance of cellulose ii: a novel multifunctional excipient. | 2012 | Chem. Pharm. Bull. | pmid:22689398 |
Griffith EC et al. | Hydrophobic collapse of a stearic acid film by adsorbed l-phenylalanine at the air-water interface. | 2012 | J Phys Chem B | pmid:22691061 |
Harvey KA et al. | Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. | 2012 | Lipids | pmid:22684911 |
Mekhail GM et al. | Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan. | 2012 | Int. J. Biol. Macromol. | pmid:22652220 |
Feugmo CG et al. | Towards modelling the vibrational signatures of functionalized surfaces: carboxylic acids on H-Si(111) surfaces. | 2012 | J Phys Condens Matter | pmid:22394578 |
Watanabe Y et al. | The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. | 2012 | Diabetes | pmid:22396206 |
Choi du H et al. | A new experimental design method to optimize formulations focusing on a lubricant for hydrophilic matrix tablets. | 2012 | Drug Dev Ind Pharm | pmid:22348254 |
Kang JH et al. | Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS). | 2012 | Eur J Pharm Biopharm | pmid:22119666 |
Schreiber R et al. | Retinyl ester hydrolases and their roles in vitamin A homeostasis. | 2012 | Biochim. Biophys. Acta | pmid:21586336 |
Bonaduce I et al. | New insights into the ageing of linseed oil paint binder: a qualitative and quantitative analytical study. | 2012 | PLoS ONE | pmid:23166642 |
Kurotani K et al. | High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | 2012 | Nutr Res | pmid:23084639 |
Simmons DM and Gierer DS | A material sparing test to predict punch sticking during formulation development. | 2012 | Drug Dev Ind Pharm | pmid:22181042 |
Niu J et al. | Octreotide-modified and pH-triggering polymeric micelles loaded with doxorubicin for tumor targeting delivery. | 2012 | Eur J Pharm Sci | pmid:22119655 |
Jung HA and Augsburger LL | Application of a novel automatic disintegration apparatus for the development and evaluation of a direct compression rapidly disintegrating tablet. | 2012 | Drug Dev Ind Pharm | pmid:22091970 |
Aissa I et al. | Synthesis of lipophilic tyrosyl esters derivatives and assessment of their antimicrobial and antileishmania activities. | 2012 | Lipids Health Dis | pmid:22264330 |
Wang Z et al. | Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling. | 2012 | Br. J. Nutr. | pmid:21733316 |
Masuda M et al. | Activating transcription factor 4 regulates stearate-induced vascular calcification. | 2012 | J. Lipid Res. | pmid:22628618 |
Slobodkina GB et al. | Deferrisoma camini gen. nov., sp. nov., a moderately thermophilic, dissimilatory iron(III)-reducing bacterium from a deep-sea hydrothermal vent that forms a distinct phylogenetic branch in the Deltaproteobacteria. | 2012 | Int. J. Syst. Evol. Microbiol. | pmid:22140176 |
Meka VS et al. | Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl. | 2012 | Invest Clin | pmid:22524109 |
Lalloo AK et al. | Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model. | 2012 | Int J Pharm | pmid:22546295 |
Chakradhar RP and Dinesh Kumar V | Water-repellent coatings prepared by modification of ZnO nanoparticles. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22575349 |
Agostini F et al. | Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. | 2012 | ScientificWorldJournal | pmid:22593706 |
Guillon A et al. | Pulmonary delivery of dry powders to rats: tolerability limits of an intra-tracheal administration model. | 2012 | Int J Pharm | pmid:22609125 |
Schrank S et al. | Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. | 2012 | AAPS PharmSciTech | pmid:22552931 |
Loutelier-Bourhis C et al. | Mechanistic study of maleic anhydride grafting onto fatty double bonds using mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22555920 |