stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Waring AJ et al. | In vivo modification of plant membrane phospholipid composition. | 1976 | Biochim. Biophys. Acta | pmid:953014 |
Woolf TB | Simulations of fatty acid-binding proteins suggest sites important for function. I. Stearic acid. | 1998 | Biophys. J. | pmid:9533682 |
Pandey M et al. | Erythrocyte membrane stearic to oleic acid ratio in carcinoma of the gallbladder: a preliminary study. | 1998 | Eur J Surg Oncol | pmid:9542515 |
Nakagawa T et al. | [Design and application of oral sustained-release anticancer drug--a new oral dosage form of cisplatin]. | 1998 | Nippon Rinsho | pmid:9549356 |
Ferrari F et al. | Dissolution enhancement of an insoluble drug by physical mixture with a superdisintegrant: optimization with a simplex lattice design. | 1996 | Pharm Dev Technol | pmid:9552342 |
Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
Björkhem I | On the mechanism of regulation of omega oxidation of fatty acids. | 1976 | J. Biol. Chem. | pmid:956185 |
Golubić M et al. | Differential regulation of neurofibromin and p120 GTPase-activating protein by nutritionally relevant fatty acids. | 1998 | Nutr Cancer | pmid:9589427 |
Dokko RC et al. | Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. | 1998 | Int. J. Biochem. Cell Biol. | pmid:9597754 |
pmid:9608395 | ||||
Rüdiger M et al. | Are biochemical parameters of lung maturation from gastric, tracheal, and pharyngeal aspirates comparable? | 1998 | Biol. Neonate | pmid:9618052 |
Steffen DG and Platner WS | Subcellular membrane fatty acids of rat heart after cold acclimation or thyroxine. | 1976 | Am. J. Physiol. | pmid:961919 |
Agarwal HC and Nair AM | Studies on the cholesterol ester hydrolase of Trogoderma (Coleoptera). | 1976 | Biochem. J. | pmid:962852 |
Aarsland A and Wolfe RR | Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. | 1998 | J. Lipid Res. | pmid:9643360 |
Tiurina OP et al. | [Modification of basic pancreatic trypsin inhibitor by fatty acid derivatives]. | 1998 | Bioorg. Khim. | pmid:9661787 |
Cabirol N et al. | Comparison of lipid composition in two types of human putrefactive liquid. | 1998 | Forensic Sci. Int. | pmid:9670483 |
Thies C | Development of injectable microcapsules for use in the treatment of narcotic addiction. | 1976 | Natl Inst Drug Abuse Res Monogr Ser | pmid:967230 |
Gray AP and Guardina WJ | Long-acting narcotic antagonist complexes. | 1976 | Natl Inst Drug Abuse Res Monogr Ser | pmid:967231 |
Hawkins DJ and Kridl JC | Characterization of acyl-ACP thioesterases of mangosteen (Garcinia mangostana) seed and high levels of stearate production in transgenic canola. | 1998 | Plant J. | pmid:9681015 |
Kang LT and Vanderhoek JY | Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. | 1998 | J. Lipid Res. | pmid:9684751 |