stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Schwarzmann G et al. | Using biotinylated gangliosides to study their distribution and traffic in cells by immunoelectron microscopy. | 2000 | Meth. Enzymol. | pmid:11070901 |
Daubresse JC | [Atherosclerosis and nutrition]. | 2000 | Rev Med Brux | pmid:11068494 |
Männistö P et al. | Absorption of erythromycin. A cross-over study in healthy volunteers. | 1975 | Arzneimittelforschung | pmid:1106445 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Janicki RS et al. | Comparison of erythromycin ethyl succinate, stearate and estolate treatments of group A streptococcal infections of the upper respiratory tract. | 1975 | Clin Pediatr (Phila) | pmid:1104241 |
French SJ et al. | The effects of intestinal infusion of long-chain fatty acids on food intake in humans. | 2000 | Gastroenterology | pmid:11040181 |
Miersch O and Wasternack C | Octadecanoid and jasmonate signaling in tomato (Lycopersicon esculentum Mill.) leaves: endogenous jasmonates do not induce jasmonate biosynthesis. | 2000 | Biol. Chem. | pmid:11030429 |
Engler MM et al. | Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats. | 2000 | Lipids | pmid:11026622 |
Mossab A et al. | Utilization of soybean oil and tallow in young turkeys compared with young chickens. | 2000 | Poult. Sci. | pmid:11020079 |
DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
Willie BM et al. | Possible explanation for the white band artifact seen in clinically retrieved polyethylene tibial components. | 2000 | J. Biomed. Mater. Res. | pmid:11007625 |
Broderick PA et al. | Monoamine neurotransmitters in resected hippocampal subparcellations from neocortical and mesial temporal lobe epilepsy patients: in situ microvoltammetric studies. | 2000 | Brain Res. | pmid:10996135 |
Hattori Y et al. | Role of phospholipase A2 in cholesterol gallstone formation is associated with biliary phospholipid species selection at the site of hepatic excretion: indirect evidence. | 2000 | Dig. Dis. Sci. | pmid:10961723 |
Hatipoglu ON and Tasan Y | A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. | 2000 | Yonsei Med. J. | pmid:10957888 |
Hennig B et al. | Fatty acid-mediated activation of vascular endothelial cells. | 2000 | Metab. Clin. Exp. | pmid:10954018 |
MuzÃk M and MuzÃková J | [Effect of magnesium stearate on internal failure of Avicel PH 101 tablets]. | 2000 | Ceska Slov Farm | pmid:10953461 |
Ishioka T et al. | Infrared and XAFS study on structure and transition behavior of zinc stearate. | 2000 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:10952134 |
Kim YC et al. | Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes. | 2000 | J. Lipid Res. | pmid:10946019 |
Khalil MH et al. | Topical application of docosanol- or stearic acid-containing creams reduces severity of phenol burn wounds in mice. | 2000 | Contact Derm. | pmid:10945745 |
Wardrop J et al. | Determination of erythromycin and related substances in enteric-coated tablet formulations by reversed-phase liquid chromatography. | 2000 | J Pharm Sci | pmid:10944374 |
Robles Valderrama E et al. | [Application of gas chromatography in the identification of Enterobacter cloacae, Enterobacter aerogenes, and Enterobacter agglomerans]. | 1999 Jan-Mar | Rev. Latinoam. Microbiol. | pmid:10932747 |
Siaan M et al. | Influence of Avicel PH-301 on the compressibility of alpha-methyldopa and phenobarbitone in direct compression. | 2000 | Drug Dev Ind Pharm | pmid:10914328 |
Lee WN et al. | Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10913044 |
Vashchuk VV and Vashchuk VV | [The use of the catalase P-47 preparation for treating long-term nonhealing wounds and trophic ulcers]. | 1993 | Klin Khir | pmid:10912018 |
Russo LI and Ghaly ES | Drug release from Carbomer 934 matrices. | 2000 | P R Health Sci J | pmid:10909708 |
Enjalbert F et al. | Effects of duodenal infusions of palmitic, stearic, or oleic acids on milk composition and physical properties of butter. | 2000 | J. Dairy Sci. | pmid:10908048 |
Bogataj M et al. | The influence of magnesium stearate on the characteristics of mucoadhesive microspheres. | 2000 Jul-Aug | J Microencapsul | pmid:10898089 |
Le Hénaff M and Fontenelle C | Chemical analysis of processing of spiralin, the major lipoprotein of Spiroplasma melliferum. | 2000 May-Jun | Arch. Microbiol. | pmid:10896212 |
Schweigert FJ and Bok V | Vitamin A in blood plasma and urine of dogs is affected by the dietary level of vitamin A. | 2000 | Int J Vitam Nutr Res | pmid:10883401 |
Robson H et al. | An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres. III. The use of DSC and HSDSC as means of characterising the interaction of the microspheres with buffered media. | 2000 | Int J Pharm | pmid:10878327 |
Stanley JC | VAT and fat. Taxing single nutrient is dangerous. | 2000 | BMJ | pmid:10877557 |
Zhang Q et al. | Studies on the cyclosporin A loaded stearic acid nanoparticles. | 2000 | Int J Pharm | pmid:10867245 |
Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
Ehinger AM and Kietzmann M | Tissue distribution of oxacillin and ampicillin in the isolated perfused bovine udder. | 2000 | J Vet Med A Physiol Pathol Clin Med | pmid:10842465 |
Bessesen DH et al. | Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10827016 |
Messier AM and Bizzozero OA | Conserved fatty acid composition of proteolipid protein during brain development and in myelin subfractions. | 2000 | Neurochem. Res. | pmid:10823577 |
Aguilella VM et al. | Double layer potential and degree of dissociation in charged lipid monolayers. | 2000 | Chem. Phys. Lipids | pmid:10823470 |
Tsuda K et al. | Role of insulin in the regulation of membrane fluidity of erythrocytes in essential hypertension: an electron paramagnetic resonance investigation. | 2000 | Am. J. Hypertens. | pmid:10821339 |
Pignatello R et al. | In vitro release kinetics of Tolmetin from tabletted Eudragit microparticles. | 2000 May-Jun | J Microencapsul | pmid:10819424 |
Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
Wissing S et al. | An investigation into the use of stepwise isothermal high sensitivity DSC as a means of detecting drug-excipient incompatibility. | 2000 | Int J Pharm | pmid:10802407 |
Schmider W et al. | Transport of heptafluorostearate across model membranes. Membrane transport of long-chain fatty acid anions I. | 2000 | J. Lipid Res. | pmid:10787438 |
Swaminathan V and Kildsig DO | The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: the effect of surface roughness of the carrier on the stability of ordered mixtures. | 2000 | Drug Dev Ind Pharm | pmid:10769777 |
Ahrabi SF et al. | Influence of neutron activation factors on matrix tablets for site specific delivery to the colon. | 2000 | Eur J Pharm Sci | pmid:10767600 |
Plötz BM et al. | Characterization of a novel lipid A containing D-galacturonic acid that replaces phosphate residues. The structure of the lipid a of the lipopolysaccharide from the hyperthermophilic bacterium Aquifex pyrophilus. | 2000 | J. Biol. Chem. | pmid:10753930 |
Florin-Christensen J et al. | Phosphatidylcholine formation is the predominant lipid biosynthetic event in the hemoparasite Babesia bovis. | 2000 | Mol. Biochem. Parasitol. | pmid:10743618 |
Muller D et al. | Niosomes as carriers of radiopaque contrast agents for X-ray imaging. | 2000 Mar-Apr | J Microencapsul | pmid:10738698 |
el-Mahdi IM and Deasy PB | Tableting of coated ketoprofen pellets. | 2000 Mar-Apr | J Microencapsul | pmid:10738689 |
Shiromani PK and Clair J | Statistical comparison of high-shear versus low-shear granulation using a common formulation. | 2000 | Drug Dev Ind Pharm | pmid:10738654 |
Sanders TA et al. | Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). | 2000 | Atherosclerosis | pmid:10729392 |