stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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MAHADEVAN S et al. | STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. | 1963 | Biochem. J. | pmid:14071526 |
MAHADEVAN S et al. | STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. | 1963 | Biochem. J. | pmid:14071527 |
TINOCO J et al. | LIVER LIPIDS OF CHOLINE-DEFICIENT RATS. | 1965 | Biochem. J. | pmid:14345885 |
Wahle KW and Garton GA | Desaturation of stearate by sheep tissue microsomal preparations. | 1972 | Biochem. J. | pmid:4643297 |
Dudley DT and Spector AA | Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells. | 1986 | Biochem. J. | pmid:3098231 |
COOKE NJ et al. | The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). | 1956 | Biochem. J. | pmid:13363830 |
DAWSON RM | The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. | 1958 | Biochem. J. | pmid:13522653 |
Bolton P and Harwood JL | Fatty acid biosynthesis by a particulate preparation from germinating pea. | 1977 | Biochem. J. | pmid:579600 |
Véret J et al. | Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. | 2011 | Biochem. J. | pmid:21592087 |
Weaire PJ and Kekwick RG | The fractionation of the fatty acid synthetase activities of avocado mesocarp plastids. | 1975 | Biochem. J. | pmid:1156381 |
Agarwal HC and Nair AM | Studies on the cholesterol ester hydrolase of Trogoderma (Coleoptera). | 1976 | Biochem. J. | pmid:962852 |
Anderton P et al. | Measles-virus-persistent infection in BGM cells. Modification of the incorporation of [3H]arachidonic acid and [14C]stearic acid into lipids. | 1983 | Biochem. J. | pmid:6414459 |
Zhang L et al. | Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. | 2001 | Biochem. J. | pmid:11415448 |
Kemp P and Lander DJ | The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. | 1983 | Biochem. J. | pmid:6318740 |
Trinchera M et al. | Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts. | 1988 | Biochem. J. | pmid:3415659 |
Graham A et al. | Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low-density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes. | 1988 | Biochem. J. | pmid:3355493 |
Le Jossic-Corcos C et al. | Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. | 2005 | Biochem. J. | pmid:15473864 |
Goto T et al. | Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. | 2011 | Biochem. J. | pmid:21605082 |
Price CJ and Rowe CE | Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pig brain in vitro by noradrenaline and 5-hydroxytryptamine. | 1972 | Biochem. J. | pmid:5075269 |
Faas FH and Carter WJ | Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism. | 1982 | Biochem. J. | pmid:7181859 |
DUNCOMBE WG and GLASCOCK RF | The contribution of dietary stearic acid to milk fat. | 1954 | Biochem. J. | pmid:13172205 |
BERGSTROM S et al. | Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. | 1954 | Biochem. J. | pmid:13230010 |
NOBLE RC and MOORE JH | FURTHER STUDIES ON THE LIPID METABOLISM OF THE NORMAL AND VITAMIN B-12 DEFICIENT CHICK EMBRYO. | 1965 | Biochem. J. | pmid:14333549 |
JAMES AT and MARTIN AJ | Gas-liquid chromatography: the separation and identification of the methyl esters of saturated and unsaturated acids from formic acid to n-octadecanoic acid. | 1956 | Biochem. J. | pmid:13315260 |
SRIDHARA S and BHAT JV | FURTHER INVESTIGATIONS OF THE INCORPORATION OF (1-14C)ACETATE INTO THE LIPIDS OF THE SILKWORM BOMBYX MORI L. | 1965 | Biochem. J. | pmid:14340061 |
ROOTS BI and JOHNSTON PV | LIPIDS OF ISOLATED NEURONS. | 1965 | Biochem. J. | pmid:14342249 |
Walker KA and Harwood JL | Localization of chloroplastic fatty acid synthesis de novo in the stroma. | 1985 | Biochem. J. | pmid:3994672 |
Trinchera M et al. | Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. | 1990 | Biochem. J. | pmid:2241913 |
McIlhinney RA and McGlone K | Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. | 1990 | Biochem. J. | pmid:2244873 |
Giudici TA et al. | Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. | 1986 | Biochem. Med. Metab. Biol. | pmid:2872907 |
Lurie E et al. | N-(2-hydroxybenzyl)-omega-amino carbonic acids and their derivatives as tools for biochemical and biophysical investigations. | 1993 | Biochem. Mol. Biol. Int. | pmid:8358340 |
Melik-Nubarov NS et al. | Interaction of hydrophobized antiviral antibodies with influenza virus infected MDCK cells. | 1993 | Biochem. Mol. Biol. Int. | pmid:8508145 |
Ohyama H et al. | Age-related differences in synaptosomal membrane fluidity. | 1995 | Biochem. Mol. Biol. Int. | pmid:8653075 |
Croxtall JD et al. | Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. | 1994 | Biochem. Pharmacol. | pmid:8304964 |
Erman A et al. | Phospholipase A2 inhibitors. Differential inhibition of fatty acid acylation into kidney lipids by mepacrine and p-bromophenacyl bromide. | 1983 | Biochem. Pharmacol. | pmid:6870935 |
Ondrias K et al. | Spin label study of the perturbation effect of the local anaesthetics tetracaine and dibucaine on synaptosomes at pharmacological concentrations. | 1987 | Biochem. Pharmacol. | pmid:2825709 |
Risé P et al. | Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines. | 2005 | Biochem. Pharmacol. | pmid:15763545 |
Hara A et al. | Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. | 2017 | Biochem. Pharmacol. | pmid:28450226 |
Rendu F et al. | Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. | 1989 | Biochem. Pharmacol. | pmid:2539823 |
Kerr BD et al. | Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. | 2009 | Biochem. Pharmacol. | pmid:19523458 |
Bruce JS et al. | Desaturation and esterification of palmitic and stearic acids in cultured hepatocytes. | 1995 | Biochem. Soc. Trans. | pmid:7672331 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
Parveez GK et al. | Transgenic oil palm: production and projection. | 2000 | Biochem. Soc. Trans. | pmid:11171275 |
Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
Liu Q et al. | Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. | 2000 | Biochem. Soc. Trans. | pmid:11288706 |
Hamilton KS et al. | Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. | 1993 | Biochemistry | pmid:8471610 |
Zornetzer GA et al. | The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. | 2010 | Biochemistry | pmid:20014832 |
Mantipragada SB et al. | Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. | 2003 | Biochemistry | pmid:12885251 |
Wolf BA et al. | Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. | 1989 | Biochemistry | pmid:2504278 |