stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Samanta AK et al. | Cone milling of compacted flakes: process parameter selection by adopting the minimal fines approach. | 2012 | Int J Pharm | pmid:22001841 |
Darwish IA et al. | Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate. | 2012 | Chem Cent J | pmid:22305461 |
Zhang J et al. | Synthesis of NaYF(4):Yb/Er/Gd up-conversion luminescent nanoparticles and luminescence resonance energy transfer-based protein detection. | 2012 | Anal. Biochem. | pmid:22155069 |
Honkanen AM et al. | Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. | 2012 | J. Dairy Sci. | pmid:22365221 |
Muro M et al. | Molecular rearrangement in a zinc stearate Langmuir film dependent on a film preparation method studied using polarization-modulation infrared reflection absorption spectroscopy and X-ray absorption fine structure. | 2012 | J Phys Chem B | pmid:22339471 |
Varshosaz J et al. | Development and evaluation of a novel pellet-based tablet system for potential colon delivery of budesonide. | 2012 | J Drug Deliv | pmid:22577558 |
Brown PN et al. | Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension. | 2011 Sep-Oct | J AOAC Int | pmid:22165004 |
Tomuta I et al. | High-Throughput NIR-Chemometric Method for Meloxicam Assay from Powder Blends for Tableting. | 2011 Oct-Dec | Sci Pharm | pmid:22145112 |
Nanjwade BK et al. | Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs. | 2011 Oct-Dec | Sci Pharm | pmid:22145101 |
Jelvehgari M et al. | Formulation, characterization and in vitro evaluation of theophylline-loaded Eudragit RS 100 microspheres prepared by an emulsion-solvent diffusion/evaporation technique. | 2011 Nov-Dec | Pharm Dev Technol | pmid:20722498 |
Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
Nath B et al. | Preparation and in vitro dissolution profile of zidovudine loaded microspheres made of Eudragit RS 100, RL 100 and their combinations. | 2011 May-Jun | Acta Pol Pharm | pmid:21648196 |
BozdaÄŸ-Pehlivan S et al. | Evaluation of drug-excipient interaction in the formulation of celecoxib tablets. | 2011 May-Jun | Acta Pol Pharm | pmid:21648198 |
Malik K et al. | Taste masked microspheres of ofloxacin: formulation and evaluation of orodispersible tablets. | 2011 Jul-Sep | Sci Pharm | pmid:21886910 |
Zaid AN et al. | Formulation and bioequivalence of two valsartan tablets after a single oral administration. | 2011 Jan-Mar | Sci Pharm | pmid:21617777 |
Shah DA et al. | Stability indicating LC-method for estimation of paracetamol and lornoxicam in combined dosage form. | 2011 Jan-Mar | Sci Pharm | pmid:21617776 |
Kumar RV and Sinha VR | Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. | 2011 | Acta Pharm | pmid:21945913 |
Jing F et al. | Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. | 2011 | BMC Biochem. | pmid:21831316 |
Liu Z et al. | [Chemical constituents from root bark of Tripterygium hypoglaucum]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22256754 |
Guntupalli R et al. | Phage Langmuir monolayers and Langmuir-Blodgett films. | 2011 | Colloids Surf B Biointerfaces | pmid:20843668 |
Saeed M et al. | Assessment of diffuse transmission and reflection modes in near-infrared quantification, part 2: DIFFuse reflection information depth. | 2011 | J Pharm Sci | pmid:20862671 |
Uchino T et al. | Effects of coating materials and size of titanium dioxide particles on their cytotoxicity and penetration into the cellular membrane. | 2011 | J Toxicol Sci | pmid:21297346 |
Shin S et al. | Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles. | 2011 | Int J Pharm | pmid:21251963 |
Calegari VC et al. | Inflammation of the hypothalamus leads to defective pancreatic islet function. | 2011 | J. Biol. Chem. | pmid:21257748 |
Uchimoto T et al. | A comparative study of glycerin fatty acid ester and magnesium stearate on the dissolution of acetaminophen tablets using the analysis of available surface area. | 2011 | Eur J Pharm Biopharm | pmid:21284955 |
Subczynski WK et al. | Spin-label oximetry at Q- and W-band. | 2011 | J. Magn. Reson. | pmid:21277814 |
Wadher KJ et al. | Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers. | 2011 | Indian J Pharm Sci | pmid:22303065 |
Potta SG et al. | Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. | 2011 | J Microencapsul | pmid:21171818 |
Mosca M et al. | Effect of membrane composition on lipid oxidation in liposomes. | 2011 | Chem. Phys. Lipids | pmid:21185813 |
Park MY et al. | Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice. | 2011 | Nutr Res Pract | pmid:22259675 |
Basu B et al. | Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material. | 2011 | J Adv Pharm Technol Res | pmid:22247895 |
Zhang Y and Clapp A | Overview of stabilizing ligands for biocompatible quantum dot nanocrystals. | 2011 | Sensors (Basel) | pmid:22247651 |
Du YZ et al. | Receptor-mediated gene delivery by folic acid-modified stearic acid-grafted chitosan micelles. | 2011 | Int J Nanomedicine | pmid:21845046 |
Sharma S et al. | RP-HPLC Method for Simultaneous Estimation of Nitazoxanide and Ofloxacin in Tablets. | 2011 | Indian J Pharm Sci | pmid:22131628 |
Lavigne JP et al. | Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. | 2011 | BMC Res Notes | pmid:22126300 |
Steidl S et al. | Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. | 2011 | PLoS ONE | pmid:22102904 |
Meissner M et al. | Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. | 2011 | PLoS ONE | pmid:22087215 |
Guschina I et al. | Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. | 2011 | Lipids | pmid:20963507 |
Bailey JA et al. | Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. | 2011 | PLoS ONE | pmid:21799757 |
Protière M et al. | Rational design of the gram-scale synthesis of nearly monodisperse semiconductor nanocrystals. | 2011 | Nanoscale Res Lett | pmid:21791060 |
Rajendraprasad N et al. | Titrimetric and spectrophotometric assay of oxcarbazepine in pharmaceuticals using N-bromosuccinimide and bromopyrogallol red. | 2011 | Int J Anal Chem | pmid:21785594 |
Bhope SG et al. | Design and development of a stable polyherbal formulation based on the results of compatibility studies. | 2011 | Pharmacognosy Res | pmid:21772756 |
Williams KJ et al. | The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. | 2011 | Tuberculosis (Edinb) | pmid:21764638 |
Zhang H et al. | Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. | 2011 | Evid Based Complement Alternat Med | pmid:21760826 |
Raza A and Zia-Ul-Haq M | Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms. | 2011 | Int J Anal Chem | pmid:21760789 |
Abdulrahman SA and Basavaiah K | Sensitive and selective spectrophotometric determination of gabapentin in capsules using two nitrophenols as chromogenic agents. | 2011 | Int J Anal Chem | pmid:21760787 |
Yang J et al. | Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. | 2011 | BMC Genomics | pmid:21631939 |
Chabukswar A et al. | Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet. | 2011 | J Young Pharm | pmid:21607050 |
Lacaze C et al. | The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. | 2011 | Malar. J. | pmid:21605361 |
Houmard JA et al. | Is there a metabolic program in the skeletal muscle of obese individuals? | 2011 | J Obes | pmid:21603262 |
Li C et al. | Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate. | 2011 | Carcinogenesis | pmid:21586513 |
Mahdi ES et al. | Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. | 2011 | Drug Des Devel Ther | pmid:21792294 |
Kalinina OV et al. | Combinations of protein-chemical complex structures reveal new targets for established drugs. | 2011 | PLoS Comput. Biol. | pmid:21573205 |
Liu Y et al. | Graphene and graphene oxide: two ideal choices for the enrichment and ionization of long-chain fatty acids free from matrix-assisted laser desorption/ionization matrix interference. | 2011 | Rapid Commun. Mass Spectrom. | pmid:22006384 |
Fabiano A et al. | Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:21781003 |
Wang Y et al. | [Analysis of plasma metabonomics of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:21288451 |
Islam A and Ehsan A | Comparison of suture material and technique of closure of subcutaneous fat and skin in caesarean section. | 2011 | N Am J Med Sci | pmid:22540072 |
Green CD and Olson LK | Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21266672 |
Santos GM et al. | Negative regulation by nuclear receptors: a plethora of mechanisms. | 2011 | Trends Endocrinol. Metab. | pmid:21196123 |
Watanabe H et al. | Biosynthetic Pathway for Sex Pheromone Components Produced in a Plusiinae Moth, Plusia festucae. | 2011 | Front Endocrinol (Lausanne) | pmid:22649385 |
Shivanand K et al. | In vivo bioavailability studies of sumatriptan succinate buccal tablets. | 2011 | Daru | pmid:22615661 |
González-Mira E et al. | Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen. | 2011 | J Pharm Sci | pmid:20575052 |
Peter A et al. | Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21045174 |
Han L et al. | Starch stearate as a novel encapsulation wall material and its effect on oil-water interfacial tension. | 2011 | J Control Release | pmid:22195872 |
Dasu MR and Jialal I | Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:20959532 |
Kouskoumvekaki I and Panagiotou G | Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules. | 2011 | J. Biomed. Biotechnol. | pmid:20936122 |
Goto T et al. | Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. | 2011 | Biochem. J. | pmid:21605082 |
Kasliwal N et al. | Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. | 2011 | Arch. Pharm. Res. | pmid:22076769 |
MužÃková J and Eimerová I | A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. | 2011 | Drug Dev Ind Pharm | pmid:21469946 |
Yoshida MI et al. | Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions. | 2011 | Drug Dev Ind Pharm | pmid:21449701 |
Kushner J et al. | Examining the impact of excipient material property variation on drug product quality attributes: a quality-by-design study for a roller compacted, immediate release tablet. | 2011 | J Pharm Sci | pmid:21319161 |
de Sousa Neto D et al. | Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I). | 2011 | Chem. Phys. Lipids | pmid:21238439 |
Seow LJ et al. | Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. | 2011 | J Ethnopharmacol | pmid:21167271 |
Price ER et al. | Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21153644 |
Lin Y et al. | Nucleating effect of calcium stearate coated CaCO(3) nanoparticles on polypropylene. | 2011 | J Colloid Interface Sci | pmid:21122873 |
Liu H et al. | A surfactant-free recipe for shape-controlled synthesis of CdSe nanocrystals. | 2011 | Nanotechnology | pmid:21169661 |
Aardema H et al. | Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. | 2011 | Biol. Reprod. | pmid:21311036 |
Pingali K et al. | Mixing order of glidant and lubricant--influence on powder and tablet properties. | 2011 | Int J Pharm | pmid:21356286 |
Zaki Rizkalla CM et al. | In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. | 2011 | AAPS PharmSciTech | pmid:21800216 |
Roblegg E et al. | Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. | 2011 | Eur J Pharm Biopharm | pmid:21801834 |
Van Hoeck V et al. | Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. | 2011 | PLoS ONE | pmid:21858021 |
El Andaloussi S et al. | Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21748634 |
Li Y et al. | Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. | 2011 | Chem. Commun. (Camb.) | pmid:21755081 |
de Morais e Silva FA et al. | Rosacea fulminans in pregnancy with ocular perforation. | 2011 | J Dtsch Dermatol Ges | pmid:21366860 |
Morinaga N et al. | Synthesis of fatty acid sterol esters using cholesterol esterase from Trichoderma sp. AS59. | 2011 | Enzyme Microb. Technol. | pmid:22113022 |
Kumar A et al. | Phytochemical investigation and antifeedant activity of Premna latifolia leaves. | 2011 | Nat. Prod. Res. | pmid:21756197 |
Tuei VC et al. | Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. | 2011 | Life Sci. | pmid:21396379 |
Lee DM et al. | Oxidative stress and inflammation in renal patients and healthy subjects. | 2011 | PLoS ONE | pmid:21829457 |
Cheng YY et al. | A novel cold-adapted lipase from Sorangium cellulosum strain So0157-2: gene cloning, expression, and enzymatic characterization. | 2011 | Int J Mol Sci | pmid:22072918 |
Peng Q et al. | A novel esterase gene cloned from a metagenomic library from neritic sediments of the South China Sea. | 2011 | Microb. Cell Fact. | pmid:22067554 |
Das SC et al. | Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. | 2011 | Eur J Pharm Sci | pmid:21621612 |
Laverroux S et al. | Isomerization of vaccenic acid to cis and trans C18:1 isomers during biohydrogenation by rumen microbes. | 2011 | Lipids | pmid:21706384 |
Someshwar K et al. | Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride. | 2011 | Acta Pharm | pmid:21684848 |
Pani NR et al. | Compatibility studies of nateglinide with excipients in immediate release tablets. | 2011 | Acta Pharm | pmid:21684850 |
Němcová-Fürstová V et al. | Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction. | 2011 | Cell. Physiol. Biochem. | pmid:21691070 |
Pereira MG et al. | Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. | 2011 | PLoS ONE | pmid:21818313 |
Xu M et al. | Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. | 2011 | J. Biol. Chem. | pmid:21697096 |
White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
Farboud ES et al. | Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies. | 2011 | Int J Nanomedicine | pmid:21674018 |
Tiţa B et al. | Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms. | 2011 | J Pharm Biomed Anal | pmid:21665404 |