stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Vorum H et al. | Palmitate and stearate binding to human serum albumin. Determination of relative binding constants. | 1997 | J. Pept. Res. | pmid:9176819 |
Wang H et al. | Apolipoprotein secretion and lipid synthesis: regulation by fatty acids in newborn swine intestinal epithelial cells. | 1997 | Am. J. Physiol. | pmid:9176199 |
Di Pierro D et al. | Separation of representative lipid compounds of biological membranes and lipid derivatives from peroxidized polyunsaturated fatty acids by reversed phase high-performance liquid chromatography. | 1997 | Free Radic. Res. | pmid:9167935 |
Frohlich BT et al. | Formation and cell-medium partitioning of autoinhibitory free fatty acids and cyclodextrin's effect in the cultivation of Bordetella pertussis. | 1996 | J. Biotechnol. | pmid:9147447 |
Aro A et al. | Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9129471 |
Gonzalez-Castro MY et al. | Effects of blanching, freezing and freeze-drying on the fatty acid contents of green beans. | 1996 | Z Lebensm Unters Forsch | pmid:9123974 |
Yamashita T and Tsubura E | [Influence of meal on the plasma concentration of patients received repeated administration of OE-7, erythromycin stearate capsules (author's transl)]. | 1977 | Jpn J Antibiot | pmid:909141 |
Tanaka H et al. | In situ observation of bovine serum albumin-adsorbed stearic acid monolayer by Brewster angle microscopy. | 1997 | J. Biochem. | pmid:9089391 |
Pai T and Yeh YY | Stearic acid modifies very low density lipoprotein lipid composition and particle size differently from shorter-chain saturated fatty acids in cultured rat hepatocytes. | 1997 | Lipids | pmid:9075203 |
Hussey HJ and Tisdale MJ | Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). | 1997 | Br. J. Cancer | pmid:9062405 |