stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Lyon RC et al. | Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. | 2002 | AAPS PharmSciTech | pmid:12916932 |
Swaminathan V and Kildsig DO | Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. | 2002 | AAPS PharmSciTech | pmid:12916934 |
Nokhodchi A et al. | Cogrinding as a tool to produce sustained release behavior for theophylline particles containing magnesium stearate. | 2009 | AAPS PharmSciTech | pmid:19862623 |
iHoroz BB et al. | Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres. | 2006 | AAPS PharmSciTech | pmid:16584146 |
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Jun HY et al. | Long residence time of ultrasound microbubbles targeted to integrin in murine tumor model. | 2010 | Acad Radiol | pmid:19815430 |
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He M et al. | Controllable stearic acid crystal induced high hydrophobicity on cellulose film surface. | 2013 | ACS Appl Mater Interfaces | pmid:23289586 |
Rambaut PC and Johnston RS | Prolonged weightlessness and calcium loss in man. | 1979 | Acta Astronaut | pmid:11883480 |
Marchut E et al. | The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells. | 1986 | Acta Biochim. Pol. | pmid:2940781 |
Liu TY and Lin YL | Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs. | 2010 | Acta Biomater | pmid:19819354 |
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Xing Z et al. | Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate. | 2010 | Acta Biomater | pmid:20226284 |
Ivanova EP et al. | Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite. | 2017 | Acta Biomater | pmid:28688988 |
Lundberg B | Thermal properties of systems containing cholesteryl esters and triglycerides. | 1976 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:1266525 |