stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sylvester PW et al. | Effects of specific fatty acids on prolactin-induced NB2 lymphoma cell proliferation. | 1993 | Life Sci. | pmid:8505862 |
Sastri MS et al. | In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. | 1993 | Arzneimittelforschung | pmid:8489559 |
Mustad VA et al. | Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. | 1993 | Metab. Clin. Exp. | pmid:8487669 |
Doering TL et al. | Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. | 1993 | J. Biol. Chem. | pmid:8486622 |
Woldseth B et al. | Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. | 1993 | Biochim. Biophys. Acta | pmid:8481391 |
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Michiels C et al. | Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. | 1993 | Am. J. Physiol. | pmid:8476019 |
Mensink RP | Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. | 1993 | Am. J. Clin. Nutr. | pmid:8475888 |
Hari PR and Sharma CP | Protein adsorption--effect of external lubricants at the interface. | 1993 | J Biomater Appl | pmid:8473987 |
Hamilton KS et al. | Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. | 1993 | Biochemistry | pmid:8471610 |
Nishihira J et al. | Identification of the hydrophobic ligand-binding region in recombinant glutathione S-transferase P and its binding effect on the conformational state of the enzyme. | 1993 | Arch. Biochem. Biophys. | pmid:8470890 |
Muszbek L and Laposata M | Myristoylation of proteins in platelets occurs predominantly through thioester linkages. | 1993 | J. Biol. Chem. | pmid:8463334 |
Derr J et al. | The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: II. The plasma total and low-density lipoprotein cholesterol response of individual fatty acids. | 1993 | Metab. Clin. Exp. | pmid:8446040 |
Poulos A et al. | Fatty acid synthesis from [2-14C]acetate in normal and peroxisome-deficient (Zellweger) fibroblasts. | 1993 | Lipids | pmid:8441343 |
Das T et al. | Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. | 1993 | Eur. J. Biochem. | pmid:8436130 |
Callaghan R et al. | Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. | 1993 | Biochim. Biophys. Acta | pmid:8435444 |
Baer HH and Wu X | Synthesis of alpha,alpha-trehalose 2,3- and 2,3'-diesters with palmitic and stearic acid: potential immunoreactants for the serodiagnosis of tuberculosis. | 1993 | Carbohydr. Res. | pmid:8431934 |
Wada H et al. | In vitro ferredoxin-dependent desaturation of fatty acids in cyanobacterial thylakoid membranes. | 1993 | J. Bacteriol. | pmid:8419301 |
Imaizumi K et al. | Fat containing stearic acid increases fecal neutral steroid excretion and catabolism of low density lipoproteins without affecting plasma cholesterol concentration in hamsters fed a cholesterol-containing diet. | 1993 | J. Nutr. | pmid:8410360 |
Emken EA et al. | Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. | 1993 | Biochim. Biophys. Acta | pmid:8399342 |
Viswanathan R et al. | Strained-layer van der Waals epitaxy in a Langmuir-Blodgett film. | 1993 | Science | pmid:8392751 |
Vilim A et al. | A simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate and ethylsuccinate. | 1977 | J. Chromatogr. | pmid:838805 |
Raines DE and Miller KW | The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. | 1993 | Biophys. J. | pmid:8386010 |
Cisar LA et al. | Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts. | 1993 | Cell. Signal. | pmid:8373725 |
Zock PL et al. | Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. | 1993 | Eur J Clin Nutr | pmid:8365385 |
Lurie E et al. | N-(2-hydroxybenzyl)-omega-amino carbonic acids and their derivatives as tools for biochemical and biophysical investigations. | 1993 | Biochem. Mol. Biol. Int. | pmid:8358340 |
Monsma CC and Ney DM | Interrelationship of stearic acid content and triacylglycerol composition of lard, beef tallow and cocoa butter in rats. | 1993 | Lipids | pmid:8355579 |
Muriana FJ et al. | Lipid and fatty acid composition of hepatopancreatic brush-border membrane vesicles from the prawn Penaeus japonicus. | 1993 | J. Biochem. | pmid:8340355 |
Patil GS and Cornwell DG | Surface phase separation and collapse of the stearate anion--alkaline earth cation complex. | 1977 | J. Lipid Res. | pmid:833501 |
Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
Tetzloff SU and Bizzozero OA | Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8323550 |
Larner JM et al. | The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. | 1993 | J. Biol. Chem. | pmid:8314757 |
Tholstrup T et al. | Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. | 1994 | Am. J. Clin. Nutr. | pmid:8310987 |
Mitropoulos KA et al. | Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. | 1994 | Arterioscler. Thromb. | pmid:8305411 |
Croxtall JD et al. | Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. | 1994 | Biochem. Pharmacol. | pmid:8304964 |
Moehren G et al. | Activation and desensitization of phospholipase D in intact rat hepatocytes. | 1994 | J. Biol. Chem. | pmid:8288637 |
Hrelia S et al. | In vivo effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositols in resting and anti-CD3-activated lymphocytes. | 1993 | Alcohol. Clin. Exp. Res. | pmid:8279665 |
Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
Koroly MJ and Conner RL | Unsaturated fatty acid biosynthesis in Tetrahymena. Evidence for two pathways. | 1976 | J. Biol. Chem. | pmid:826532 |
Ramanadham S et al. | Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. | 1993 | Biochemistry | pmid:8257685 |
Visioli F et al. | Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation. | 1993 | J. Neurochem. | pmid:8228997 |
Samochocki M and Strosznajder J | Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranes. | 1993 | Neurochem. Int. | pmid:8220171 |
Lee WN et al. | In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. | 1994 | Am. J. Physiol. | pmid:8203508 |
Doering TL et al. | The fatty acids in unremodelled trypanosome glycosyl-phosphatidylinositols. | 1994 | Biochem. J. | pmid:8192662 |
Batten TL et al. | Contact dermatitis from the old formula E45 cream. | 1994 | Contact Derm. | pmid:8187515 |
Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
Lu B et al. | Characterization of modified staphylococcal protein A containing phospholipid monolayer on both solution and slide surfaces. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8185601 |
Chigorno V et al. | Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-14C]palmitic acid and [1-14C]stearic acid to rat cerebellar granule cells in culture. | 1994 | Eur. J. Biochem. | pmid:8181467 |
Musty PR and Nickless G | Extractants for organochlorine insecticides and polychlorinated biphenyls from water. | 1976 | J. Chromatogr. | pmid:818099 |
Hyson DA et al. | Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits. | 1994 | Lipids | pmid:8177021 |