stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wahle KW and Garton GA | Desaturation of stearate by sheep tissue microsomal preparations. | 1972 | Biochem. J. | pmid:4643297 |
Conte U et al. | The effect of magnesium stearate and polytetrafluoroethylene as lubricants in direct compression of acetylsalicylic acid. | 1972 | Farmaco Prat | pmid:5049531 |
Lesslauer W and Blasie JK | Direct determination of the structure of barium stearate multilayers by x-ray diffraction. | 1972 | Biophys. J. | pmid:5057749 |
Price CJ and Rowe CE | Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pig brain in vitro by noradrenaline and 5-hydroxytryptamine. | 1972 | Biochem. J. | pmid:5075269 |
Patil GS et al. | Effect of ionization and cation selectivity on the expansion of stearic acid monolayers. | 1972 | J. Lipid Res. | pmid:5075503 |
Miyake Y et al. | [Studies on packing-property of pharmaceutical powders. II. Compacting phenomenon of pharmaceutical powders in the course of mixing with calcium stearate]. | 1972 | Yakugaku Zasshi | pmid:4675495 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Butcher AE and Jones TM | Some physical characteristics of magnesium stearate. | 1972 | J. Pharm. Pharmacol. | pmid:4144914 |
Ryan DC et al. | Estolate and stearate forms of erythromycin in the treatment of acute beta haemolytic streptococcal pharyngitis. | 1973 | Med. J. Aust. | pmid:4568626 |
Bond JM et al. | The second international reference preparation of procaine benzylpenicillin in oil with aluminium monostearate. | 1973 | Bull. World Health Organ. | pmid:4541152 |
Arya OP and Bosa CB | In search of an ideal single-session penicillin schedule for the treatment of gonorrhoea in Uganda. | 1973 | Br J Vener Dis | pmid:4748409 |
McLeay A and Cooke P | Estolate and stearate forms of erythromycin in beta-haemolytic streptococcal pharyngitis. | 1973 | Med. J. Aust. | pmid:4694278 |
Norwitz G and Gordon H | Determination of lithium stearate in sebacate-based lubricants by atomic absorption. | 1973 | Talanta | pmid:18961363 |
Miyake Y et al. | [Studies on packing-property of pharmaceutical powders. 3. Influence of calcium stearate content on compacting phenomenon of pharmaceutical powders (author's transl)]. | 1973 | Yakugaku Zasshi | pmid:4797567 |
Antimicrobial efficacy of erythromycin stearate. A report from the general Practitioner Research Group. | 1974 | Practitioner | pmid:4591200 | |
Caldwell HC | Dissolution of lithium and magnesium from lithium carbonate capsules containing magnesium stearate. | 1974 | J Pharm Sci | pmid:4830001 |
Beleslin DB et al. | Hyperthermic effect of palmitate sodium, stearate sodium and oleate sodium injected into the cerebral ventricles of conscious cats. | 1974 | Neuropharmacology | pmid:4840846 |
Kasuya M et al. | Toxic effect of cadmium stearate on rat cerebellum in culture. | 1974 | Bull Environ Contam Toxicol | pmid:4474041 |
McGee R and Spector AA | Fatty acid biosynthesis in Erlich cells. The mechanism of short term control by exogenous free fatty acids. | 1975 | J. Biol. Chem. | pmid:237919 |
Choulis NH and Papadopoulos H | Factors effecting drug release from inert matrices. Part 1: effects of surfactants on the release of quinine sulfate. | 1975 | Pharmazie | pmid:239411 |
Kalm O et al. | Erythromycin stearate in acute maxillary sinusitis. | 1975 | Scand. J. Infect. Dis. | pmid:241119 |
Bieri VG and Wallach DF | Variations of lipid-protein interactions in erythrocyte ghosts as a function of temperature and pH in physiological and non-physiological ranges. A study using a paramagnetic quenching of protein fluorescence by nitroxide lipid analogues. | 1975 | Biochim. Biophys. Acta | pmid:241415 |
Seng PN and Debuch H | [Studies on the stearic acid dehydrogenase in the liver and brain of rats of various ages (author's transl)]. | 1975 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:241688 |
Topping DL and Targ ME | Time-course of changes in blood glucose and ketone bodies, plasma lipids and liver fatty acid composition in streptozotocin-diabetic male rats. | 1975 | Horm. Res. | pmid:130333 |
Comai K et al. | Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits. | 1975 | Lipids | pmid:1177669 |
Thompson GE and Darling KF | The hepatic uptake of individual free fatty acids in sheep during noradrenaline infusion. | 1975 | Res. Vet. Sci. | pmid:1144925 |
York P | Application of powder failure testing equipment in assessing effect on glidants on flowability of cohesive pharmaceutical powders. | 1975 | J Pharm Sci | pmid:1151687 |
Weaire PJ and Kekwick RG | The fractionation of the fatty acid synthetase activities of avocado mesocarp plastids. | 1975 | Biochem. J. | pmid:1156381 |
Janicki RS et al. | Comparison of erythromycin ethyl succinate, stearate and estolate treatments of group A streptococcal infections of the upper respiratory tract. | 1975 | Clin Pediatr (Phila) | pmid:1104241 |
Männistö P et al. | Absorption of erythromycin. A cross-over study in healthy volunteers. | 1975 | Arzneimittelforschung | pmid:1106445 |
Anderson RR et al. | Composition of cottontail rabbit milk from stomachs of young and directly from gland. | 1975 | J. Dairy Sci. | pmid:1184805 |
Gaginella TS et al. | Actions of ricinoleic acid and structurally related fatty acids on the gastrointestinal tract. II. Effects on water and electrolyte absorption in vitro. | 1975 | J. Pharmacol. Exp. Ther. | pmid:1185605 |
Smith RW and Walsh A | Composition of liver lipids of the rat during pregnancy and lactation. | 1975 | Lipids | pmid:1186452 |
Schmidt P et al. | [Animal experiments on barium stearate toxicity]. | 1975 | Z Gesamte Hyg | pmid:1189478 |
Sato M et al. | [Clinical studies on OE-7 chiefly in the treatment of acute respiratory infections (author's transl)]. | 1975 | Jpn J Antibiot | pmid:1195513 |
Harwood JL and James AT | Metabolism of trans-3-hexadecenoic acid in broad bean. | 1975 | Eur. J. Biochem. | pmid:1126340 |
Kuksis A et al. | Distribution of newly formed fatty acids among glycerolipids of isolated perfused rat liver. | 1975 | Can. J. Biochem. | pmid:1139394 |
Kuksis A et al. | Distribution of newly formed palmitate and stearate among molecular species of choline and ethanolamine phosphatides. | 1975 | Can. J. Biochem. | pmid:1139395 |
Parkes JG and Thompson W | Phosphatidylethanolamine in liver mitochondria and endoplasmic reticulum: molecular species distribution and turnover. | 1975 | Can. J. Biochem. | pmid:1139407 |
Tola S | Occupational lead exposure in Finland. IV. The polyvinyl chloride plastic industry. | 1975 | Scand J Work Environ Health | pmid:1228897 |
Kopp F et al. | Instability of Langmuir-Blodgett layers of barium stearate, cadmium arachidate and tripalmitin, studied by means of electron microscopy and infrared spectroscopy. | 1975 | Biophys. Struct. Mech. | pmid:1234025 |
Gray AP and Guardina WJ | Long-acting narcotic antagonist complexes. | 1975 | Natl Inst Drug Abuse Res Monogr Ser | pmid:1234981 |
Ercoli N | [Clinical and experimental study on an anti-inflammatory preparation of topical use. The 10-undecentil-l-ll pseudothiourea (AHR-1911)]. | 1975 | Med Cutan Ibero Lat Am | pmid:1241792 |
Thies C | Development of injectable microcapsules for use in the treatment of narcotic addiction. | 1975 | Natl Inst Drug Abuse Res Monogr Ser | pmid:1241971 |
Aveldano MI and Bazán NG | Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemia. | 1975 | J. Neurochem. | pmid:1206411 |
Pollet S et al. | [Substrates and products of fatty acid elongation in mouse brain microsomes]. | 1975 | Biochimie | pmid:1222143 |
Wood R | Sterospecific analysis of hepatoma, host liver, and normal rat liver triglycerides from animals on chow and fat free diets. | 1975 | Lipids | pmid:167260 |
Iot T et al. | Synthesis of a new phosphatidylserine spin-label and calcium-induced lateral phase separation in phosphatidylserine-phosphatidylcholine membranes. | 1975 | Biochemistry | pmid:167814 |
Thompson W and MacDonald G | Isolation and characterization of cytidine diphosphate diglyceride from beef liver. | 1975 | J. Biol. Chem. | pmid:169258 |
Morrisett JD et al. | Multiple thermotropic phase transitions in Escherichia coli membranes and membrane lipids. A comparison of results obtained by nitroxyl stearate paramagnetic resonance, pyrene excimer fluorescence, and enzyme activity measurements. | 1975 | J. Biol. Chem. | pmid:169264 |
Asker AF et al. | Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 5: Effects of lubricants and flow conditions. | 1975 | Pharmazie | pmid:169527 |
Phadke RS | Sedimentation test for procaine benzylpenicillin in oil with aluminium monostearate. III. Substitution of the sedimentation rate for the blood-level duration test of WHO in rabbits. | 1975 Aug-Nov | Hindustan Antibiot Bull | pmid:1236093 |
Koroly MJ and Conner RL | Unsaturated fatty acid biosynthesis in Tetrahymena. Evidence for two pathways. | 1976 | J. Biol. Chem. | pmid:826532 |
Waring AJ et al. | In vivo modification of plant membrane phospholipid composition. | 1976 | Biochim. Biophys. Acta | pmid:953014 |
Björkhem I | On the mechanism of regulation of omega oxidation of fatty acids. | 1976 | J. Biol. Chem. | pmid:956185 |
Steffen DG and Platner WS | Subcellular membrane fatty acids of rat heart after cold acclimation or thyroxine. | 1976 | Am. J. Physiol. | pmid:961919 |
Adachi H et al. | Effect of long-chain acyl-CoA on the omega-oxidation of monocarboxylic acid. | 1976 | Hokkaido Igaku Zasshi | pmid:985795 |
Porra RJ and Stumpf PK | Lipid biosynthesis in developing and germinating soybean cotyledons. The formation of palmitate and stearate by chopped tissue and supernatant preparations. | 1976 | Arch. Biochem. Biophys. | pmid:987755 |
Weber J et al. | [Can zinc stearate cause lung fibrosis? (Case report)]. | 1976 | Beitr Silikoseforsch Pneumokoniose | pmid:990095 |
Yamashita T et al. | [Studies on erythromycin stearate capsules (OE-7) (author's transl)]. | 1976 | Jpn J Antibiot | pmid:933342 |
Thies C | Development of injectable microcapsules for use in the treatment of narcotic addiction. | 1976 | Natl Inst Drug Abuse Res Monogr Ser | pmid:967230 |
Gray AP and Guardina WJ | Long-acting narcotic antagonist complexes. | 1976 | Natl Inst Drug Abuse Res Monogr Ser | pmid:967231 |
Eliasz AW et al. | Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds. | 1976 | Biochim. Biophys. Acta | pmid:971432 |
Graham KC et al. | Simple thin-layer chromatographic identification method for erythromycin stearate. | 1976 | J. Chromatogr. | pmid:977688 |
Matsuda Y et al. | Comparative evaluation of tablet lubricants: effect of application method on tablet hardness and ejectability after compression. | 1976 | J Pharm Sci | pmid:978434 |
Caster WO et al. | Effect of dietary palmitate, stearate, oleate and linoleate on the tissue lipid and systolic blood pressure of the rat. | 1976 | Int J Vitam Nutr Res | pmid:1010686 |
Brown ST | Treatment of secondary syphilis. | 1976 | J Am Vener Dis Assoc | pmid:1010778 |
Hannuksela M et al. | Contact sensitivity to emulsifiers. | 1976 | Contact Derm. | pmid:1021350 |
Horhota ST et al. | Effect of storage at specified temperature and humidity on properties of three directly compressible tablet formulations. | 1976 | J Pharm Sci | pmid:1032656 |
Shen WW et al. | Effect of nonionic surfactants on percutaneous absorption of salicylic acid and sodium salicylate in the presence of dimethyl sulfoxide. | 1976 | J Pharm Sci | pmid:1032661 |
Müller WE | The use of 8-anilino-1-naphthalenesulfonic acid as a reporter group molecule for circular dichroism and fluorescence measurements. The effect of stearic acid and sodium dodecylsulfate on the conformation of bovine and human serum albumin. | 1976 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:1033907 |
Norwitz G and Galan M | Determination of barium and strontium peroxides (active oxygen) in igniters in small-arms tracer ammunition. | 1976 | Talanta | pmid:18961958 |
Whorton AR et al. | The metabolism of (1-14C) stearic acid in rat testicular tissue. | 1976 | Biochim. Biophys. Acta | pmid:1252481 |
Fee JV et al. | Influence of hydrophobic materials on dissolution of a nondisintegrating hydrophilic solid (potassium chloride). | 1976 | J Pharm Sci | pmid:1255446 |
Yamashita T et al. | [Blood concentration and urinary excretion in human of OE-7, a gastric hard capsule containing enteric-coated granules. I (author's transl)]. | 1976 | Jpn J Antibiot | pmid:1263346 |
Agarwal HC and Nair AM | Studies on the cholesterol ester hydrolase of Trogoderma (Coleoptera). | 1976 | Biochem. J. | pmid:962852 |
Thompson W and MacDonald G | Cytidine diphosphate diglyceride of bovine brain. Positional distribution of fatty acids and analysis of major molecular species. | 1976 | Eur. J. Biochem. | pmid:776622 |
Warhurst DC et al. | The chemotherapy of rodent malaria, XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei. | 1976 | Ann Trop Med Parasitol | pmid:788656 |
Boggiano BG and Gleeson M | Gastric acid inactivation of erythromycin stearate in solid dosage forms. | 1976 | J Pharm Sci | pmid:5588 |
Ahmed M and Enever RP | Influence of magnesium stearate on the dissolution and biological availability of sulphadiazine tablet formulations [proceedings]. | 1976 | J. Pharm. Pharmacol. | pmid:12326 |
Sabbah A | [Letter: Immunodepressive action of erythromycin ethyl-succinate and erythromycin stearate. Study by the lymphoblastic transformation test and natural and rheumatoid rosette test]. | 1976 | Nouv Presse Med | pmid:1264643 |
Lundberg B | Thermal properties of systems containing cholesteryl esters and triglycerides. | 1976 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:1266525 |
Pickart LR and Thaler MM | Free fatty acids and albumin as mediators of thrombin-stimulated fibrinogen synthesis. | 1976 | Am. J. Physiol. | pmid:1267031 |
Musty PR and Nickless G | Extractants for organochlorine insecticides and polychlorinated biphenyls from water. | 1976 | J. Chromatogr. | pmid:818099 |
Soler-Argilaga C et al. | The effect of sex on the quantity and properties of the very low density lipoprotein secreted by the liver in vitro. | 1976 | J. Lipid Res. | pmid:178815 |
Uyesaka N et al. | Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. | 1976 | J. Membr. Biol. | pmid:181579 |
Miller RW and De La Roche IA | Properties of spin labelled membranes of Fusarium oxysporum f. sp. lycopersici. | 1976 | Biochim. Biophys. Acta | pmid:182261 |
Ruf HH and Gratzl M | Binding of nitroxide stearate spin labels to bovine serum albumin. | 1976 | Biochim. Biophys. Acta | pmid:184832 |
Todorow S and Elies W | [Oily contrast medium in liquor space following myelography. A clinical-radiological study on extent, velocity and ways of elimination of monoiodine stearate]. | 1976 | Neurochirurgia (Stuttg) | pmid:185538 |
Marai L et al. | Identification of isomeric doxyl stearic acids by gas-liquid chromatography and mass spectrometry. | 1976 | Chem. Phys. Lipids | pmid:186203 |
Zenser TV et al. | Spin-labeled stearates as probes for microenvironment of murine thymocyte adenylate cyclase-cyclic adenosine 3':5'-monophosphate system. | 1976 | J. Biol. Chem. | pmid:187588 |
Moës A | [Influence of the addition of aluminium stearate and of colloidal silica on the properties of rectal suppositories formulations (author's transl)]. | 1976 Jul-Aug | J Pharm Belg | pmid:185351 |
Murthy KS and Samyn JC | Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants. | 1977 | J Pharm Sci | pmid:903855 |
Yamashita T and Tsubura E | [Influence of meal on the plasma concentration of patients received repeated administration of OE-7, erythromycin stearate capsules (author's transl)]. | 1977 | Jpn J Antibiot | pmid:909141 |
Galpin JR and Allen JC | The influence of micelle formation on lipoxygenase kinetics. | 1977 | Biochim. Biophys. Acta | pmid:409436 |
Bolton P and Harwood JL | Some characteristics of soluble fatty acid synthesis in germinating pea seeds. | 1977 | Biochim. Biophys. Acta | pmid:20971 |
Rowe RC | The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. | 1977 | J. Pharm. Pharmacol. | pmid:22617 |
Sixsmith D | The properties of tablets containing microcrystalline cellulose. | 1977 | J. Pharm. Pharmacol. | pmid:15069 |
Donaldson RP and Beevers H | Lipid composition of organelles from germinating castor bean endosperm. | 1977 | Plant Physiol. | pmid:16659829 |
Uyesaka N | Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. J. Membrane Biol. 27:283. | 1977 | J. Membr. Biol. | pmid:190405 |