stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ragnarsson G and Sjögren J | Force-displacement measurements in tableting. | 1985 | J. Pharm. Pharmacol. | pmid:2858558 |
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Bangudu AB and Pilpel N | Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures. | 1985 | J. Pharm. Pharmacol. | pmid:2862234 |
Yasuda H et al. | Biphasic liberation of arachidonic and stearic acids during cerebral ischemia. | 1985 | J. Neurochem. | pmid:2987409 |
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Shanson DC et al. | Erythromycin stearate, 1.5 g, for the oral prophylaxis of streptococcal bacteraemia in patients undergoing dental extraction: efficacy and tolerance. | 1985 | J. Antimicrob. Chemother. | pmid:3882657 |
Boiron F et al. | A comparison of substrate-dependent fatty acyl-CoA synthetase activities and ATP hydrolysis in membrane pellets from normal and trembler mouse sciatic nerves. | 1985 | Neurochem. Int. | pmid:20492990 |
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Wood CB et al. | Reduction in the stearic to oleic acid ratio in the circulating red blood cells: a possible tumour marker in solid human neoplasms. | 1985 | Eur J Surg Oncol | pmid:4007173 |
Harrison GA et al. | Resistance in oral streptococci after repeated three-dose erythromycin prophylaxis. | 1985 | J. Antimicrob. Chemother. | pmid:4008379 |
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Ruwart MJ et al. | 16,16-Dimethyl PGE2 and fatty acids protect hepatocytes against CCl4-induced damage. | 1985 | In Vitro Cell. Dev. Biol. | pmid:4030626 |
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Willcox RR | Mass treatment campaigns against the endemic treponematoses. | 1985 May-Jun | Rev. Infect. Dis. | pmid:4012173 |
Brown ST | Therapy for nonvenereal treponematoses: review of the efficacy of penicillin and consideration of alternatives. | 1985 May-Jun | Rev. Infect. Dis. | pmid:4012176 |
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Catalá A | Stearic acid desaturation in rat liver microsomes: stimulation by fatty acid binding protein. | 1986 | Acta Physiol Pharmacol Latinoam | pmid:2876583 |
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Crosby T et al. | Identification of ecdysone 22-long-chain fatty acyl esters in newly laid eggs of the cattle tick Boophilus microplus. | 1986 | Biochem. J. | pmid:3030275 |
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Dudley DT and Spector AA | Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells. | 1986 | Biochem. J. | pmid:3098231 |
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Smith DM and Waite M | Phospholipid metabolism in human neutrophil subfractions. | 1986 | Arch. Biochem. Biophys. | pmid:3083776 |
Singh H and Poulos A | A comparative study of stearic and lignoceric acid oxidation by human skin fibroblasts. | 1986 | Arch. Biochem. Biophys. | pmid:3767370 |
Goto S et al. | [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. | 1986 | Yakugaku Zasshi | pmid:3701600 |
Shah KB et al. | An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. | 1986 | J Pharm Sci | pmid:3701614 |
Wan LS and Choong YL | The effect of excipients on the penetration of liquid into tablets. | 1986 | Pharm Acta Helv | pmid:3725815 |
Oh-Hashi Y et al. | Temperature- and growth-phase-dependent changes in membrane fatty acid compositions of Brevibacterium ammoniagenes. | 1986 | Arch. Biochem. Biophys. | pmid:3729431 |
Carter-Dawson L et al. | Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. | 1986 | Dev. Biol. | pmid:3732615 |
Chowhan ZT and Chi LH | Drug-excipient interactions resulting from powder mixing. III: Solid state properties and their effect on drug dissolution. | 1986 | J Pharm Sci | pmid:3735096 |
Chowhan ZT and Chi LH | Drug-excipient interactions resulting from powder mixing. IV: Role of lubricants and their effect on in vitro dissolution. | 1986 | J Pharm Sci | pmid:3735097 |
Fujii T et al. | Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity. | 1986 | Biochem. Int. | pmid:3741447 |
Chester DW et al. | The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. | 1986 | Biochim. Biophys. Acta | pmid:3741857 |
Tsao FH | Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung. | 1986 | Lipids | pmid:3796238 |
Ito Y et al. | Fatty acid synthetase as a thermoreceptor in Candida utilis. | 1986 | J. Biochem. | pmid:3745143 |
Muralidharan FN and Muralidharan VB | Phytanoyl-CoA ligase activity in rat liver. | 1986 | Biochem. Int. | pmid:3753503 |
Ball MD et al. | Acyl coenzyme A:retinol acyltransferase activity and the vitamin A content of polar bear (Ursus maritimus) liver. | 1986 | Comp. Biochem. Physiol., B | pmid:3757481 |
van den Reek MM et al. | Use of published analyses of food items to determine dietary trans octadecenoic acid. | 1986 | J Am Diet Assoc | pmid:3760430 |
Sugimoto Y et al. | A 2H NMR study on alteration of the membrane organization of mouse B16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate. | 1986 | J. Biochem. | pmid:3818567 |
Thompson W and Belina H | Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. | 1986 | Biochim. Biophys. Acta | pmid:3707975 |
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Beaumelle BD and Vial HJ | Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. | 1986 | Biochim. Biophys. Acta | pmid:3719005 |
Pajor L et al. | Microsomal desaturation of stearic acid in relation to lymphocyte activation. | 1986 | Arch. Biochem. Biophys. | pmid:3485399 |
Ras GJ and Anderson R | An in-vitro study of oral therapeutic doses of co-trimoxazole and erythromycin stearate on abnormal polymorphonuclear leucocyte migration. | 1986 | J. Antimicrob. Chemother. | pmid:3486178 |
Peura P et al. | The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. | 1986 | Arch. Toxicol. Suppl. | pmid:3468932 |
Slomiany BL et al. | Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. | 1986 | Biochim. Biophys. Acta | pmid:3518803 |
Muñoz-Espin T et al. | Erythromycin versus tetracycline for treatment of Mediterranean spotted fever. | 1986 | Arch. Dis. Child. | pmid:3535687 |
Mazière C et al. | Cyclic AMP increases incorporation of exogenous fatty acids into triacylglycerols in hamster fibroblasts. | 1986 | Lipids | pmid:3020335 |
Chalupa W et al. | Ruminal fermentation in vivo as influenced by long-chain fatty acids. | 1986 | J. Dairy Sci. | pmid:3722545 |
Sakaguchi M et al. | Effects of dietary saturated and unsaturated fatty acids on fecal bile acids and colon carcinogenesis induced by azoxymethane in rats. | 1986 | Cancer Res. | pmid:3940210 |
Bankson DD et al. | Determination of retinyl esters and retinol in serum or plasma by normal-phase liquid chromatography: method and applications. | 1986 | Clin. Chem. | pmid:3940733 |
Yamamoto O | Radiation-induced crosslinks between carboxylic acids and compounds of biological interest. | 1986 | Radiat. Res. | pmid:3952268 |
Villa P et al. | Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver. | 1986 | J. Antibiot. | pmid:3084433 |
Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Johansson ME and Nicklasson M | Investigation of the film formation of magnesium stearate by applying a flow-through dissolution technique. | 1986 | J. Pharm. Pharmacol. | pmid:2869127 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
Alcalay J et al. | Asymptomatic liver injury due to erythromycin stearate. | 1986 Jul-Aug | Drug Intell Clin Pharm | pmid:3743417 |
Goto S et al. | Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen. | 1986 Oct-Dec | J Microencapsul | pmid:3508190 |
Goto S et al. | Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen. | 1986 Oct-Dec | J Microencapsul | pmid:3508191 |
Adebayo GI et al. | Time-dependent inhibition of theophylline elimination by erythromycin stearate. | 1986 Sep-Oct | Biopharm Drug Dispos | pmid:3779037 |
West AA et al. | The relationship between glycosyltransferase production and membrane fatty acid composition of Streptococcus sanguis NCTC 7865 grown in the presence of protonmotive force inhibitors. | 1987 | J. Gen. Microbiol. | pmid:2966234 |
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Reddy TS and Bazan NG | Arachidonic acid, stearic acid, and diacylglycerol accumulation correlates with the loss of phosphatidylinositol 4,5-bisphosphate in cerebrum 2 seconds after electroconvulsive shock: complete reversion of changes 5 minutes after stimulation. | 1987 | J. Neurosci. Res. | pmid:2830409 |
Ogata S et al. | Chemical identification of lipid components in the membranous form of rat liver alkaline phosphatase. | 1987 | J. Biochem. | pmid:2834351 |
Swendsen CL et al. | Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids. | 1987 | Biochim. Biophys. Acta | pmid:3105590 |
Rhoads DE et al. | Metabolism of saturated fatty acids by Paramecium tetraurelia. | 1987 | J. Lipid Res. | pmid:3430068 |
Berlin E et al. | Influence of saturated and unsaturated fats on platelet fatty acids in cholesterol-fed rabbits. | 1987 | Atherosclerosis | pmid:3827974 |
Seifert R et al. | Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3426598 |
Bos CE et al. | Native starch in tablet formulations: properties on compaction. | 1987 | Pharm Weekbl Sci | pmid:3432037 |
Nadai M et al. | [Correlation between in vitro dissolution characteristics of macrolide antibiotic tablets and bioavailability in man]. | 1987 | Yakugaku Zasshi | pmid:3437396 |
Hasin Y et al. | Dietary lipid intake and myocardial electrophysiology. | 1987 | Isr. J. Med. Sci. | pmid:3440741 |
Cutler RR et al. | The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. | 1987 | Tubercle | pmid:3448797 |
Matsui MS and Jeffrey AM | Fatty acid modification of C3H 10T 1/2 fibroblast cells: changes in benzo(a)pyrene metabolism and phorbol ester binding. | 1987 | Cancer Res. | pmid:3471326 |
Hattori T et al. | Membrane phospholipid composition and membrane fluidity of human brain tumour: a spin label study. | 1987 | Neurol. Res. | pmid:2883605 |
Søreide O et al. | Inadequacy of oleic acid in erythrocytes as a marker of malignancies. | 1987 | Br Med J (Clin Res Ed) | pmid:3103770 |