| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Burns | D002056 | 34 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| pmid:9608395 | ||||
| Luo L et al. | Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. | 2007 | AAPS J | pmid:18170979 |
| Kuppuswamy R et al. | Estimation of capping incidence by indentation fracture tests. | 2001 | AAPS PharmSci | pmid:11741256 |
| Otsuka M et al. | Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process. | 2001 | AAPS PharmSci | pmid:11741271 |
| Shah RB et al. | Comparative evaluation of flow for pharmaceutical powders and granules. | 2008 | AAPS PharmSciTech | pmid:18446489 |
| Darole PS et al. | Formulation and evaluation of microemulsion based delivery system for amphotericin B. | 2008 | AAPS PharmSciTech | pmid:18446472 |
| Kottala N et al. | Evaluation of the performance characteristics of bilayer tablets: Part II. Impact of environmental conditions on the strength of bilayer tablets. | 2012 | AAPS PharmSciTech | pmid:22965660 |
| Patel S et al. | Lubrication potential of magnesium stearate studied on instrumented rotary tablet press. | 2007 | AAPS PharmSciTech | pmid:18181549 |
| Daraghmeh N et al. | Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol. | 2010 | AAPS PharmSciTech | pmid:21052880 |
| Casiraghi A et al. | The influence of the polar head and the hydrophobic chain on the skin penetration enhancement effect of poly(ethylene glycol) derivatives. | 2012 | AAPS PharmSciTech | pmid:22232021 |
| Almaya A and Aburub A | Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. | 2008 | AAPS PharmSciTech | pmid:18431664 |
| Patel K et al. | Duloxetine HCl lipid nanoparticles: preparation, characterization, and dosage form design. | 2012 | AAPS PharmSciTech | pmid:22167415 |
| Morkhade DM et al. | PEGylated rosin derivatives: novel microencapsulating materials for sustained drug delivery. | 2007 | AAPS PharmSciTech | pmid:17622122 |
| Ramirez-Dorronsoro JC et al. | Chargeability measurements of selected pharmaceutical dry powders to assess their electrostatic charge control capabilities. | 2006 | AAPS PharmSciTech | pmid:17285749 |
| Navaneethan CV et al. | Application of powder rheometer to determine powder flow properties and lubrication efficiency of pharmaceutical particulate systems. | 2005 | AAPS PharmSciTech | pmid:16353997 |
| Soares LA et al. | Dry granulation and compression of spray-dried plant extracts. | 2005 | AAPS PharmSciTech | pmid:16353993 |
| Tatavarti AS et al. | Assessment of NIR spectroscopy for nondestructive analysis of physical and chemical attributes of sulfamethazine bolus dosage forms. | 2005 | AAPS PharmSciTech | pmid:16353969 |
| Sovány T et al. | Application of physicochemical properties and process parameters in the development of a neural network model for prediction of tablet characteristics. | 2013 | AAPS PharmSciTech | pmid:23413109 |
| Missaghi S and Fassihi R | A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. | 2004 | AAPS PharmSciTech | pmid:15760087 |
| Ferrari F et al. | The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. | 2004 | AAPS PharmSciTech | pmid:15760057 |
| Lyon RC et al. | Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. | 2002 | AAPS PharmSciTech | pmid:12916932 |
| Swaminathan V and Kildsig DO | Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. | 2002 | AAPS PharmSciTech | pmid:12916934 |
| Gupta A et al. | Difference in the lubrication efficiency of bovine and vegetable-derived magnesium stearate during tabletting. | 2009 | AAPS PharmSciTech | pmid:19390976 |
| Zhou QT et al. | Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. | 2013 | AAPS PharmSciTech | pmid:23196863 |
| Nokhodchi A et al. | Cogrinding as a tool to produce sustained release behavior for theophylline particles containing magnesium stearate. | 2009 | AAPS PharmSciTech | pmid:19862623 |
| Mir VG et al. | Application of crustacean chitin as a co-diluent in direct compression of tablets. | 2010 | AAPS PharmSciTech | pmid:20238188 |
| Lakio S et al. | Challenges in detecting magnesium stearate distribution in tablets. | 2013 | AAPS PharmSciTech | pmid:23378252 |
| Cunha TA et al. | Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. | 2013 | AAPS PharmSciTech | pmid:23897034 |
| iHoroz BB et al. | Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres. | 2006 | AAPS PharmSciTech | pmid:16584146 |
| Seitavuopio P et al. | Monitoring tablet surface roughness during the film coating process. | 2006 | AAPS PharmSciTech | pmid:16796349 |
| Zhang SW et al. | A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs. | 2014 | AAPS PharmSciTech | pmid:25037732 |
| Zaki Rizkalla CM et al. | In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. | 2011 | AAPS PharmSciTech | pmid:21800216 |
| Shidhaye SS et al. | Buccal drug delivery of pravastatin sodium. | 2010 | AAPS PharmSciTech | pmid:20300898 |
| Räsänen E et al. | A new method to predict flowability using a microscale fluid bed. | 2003 | AAPS PharmSciTech | pmid:15198548 |
| Li S et al. | Preparation, characterization, pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with tetrandrine. | 2011 | AAPS PharmSciTech | pmid:21811889 |
| Waters LJ et al. | Controlled microwave processing applied to the pharmaceutical formulation of ibuprofen. | 2011 | AAPS PharmSciTech | pmid:21842309 |
| Salbu L et al. | Direct compression behavior of low- and high-methoxylated pectins. | 2010 | AAPS PharmSciTech | pmid:20013080 |
| Khan FN and Dehghan MH | Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. | 2011 | AAPS PharmSciTech | pmid:21879394 |
| Swaminathan V and Kildsig DO | An examination of the moisture sorption characteristics of commercial magnesium stearate. | 2001 | AAPS PharmSciTech | pmid:14727865 |
| Fernández EG et al. | Rapid development and optimization of tablet manufacturing using statistical tools. | 2008 | AAPS PharmSciTech | pmid:18459048 |
| Chang CK et al. | Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc. | 2008 | AAPS PharmSciTech | pmid:18459052 |
| Kumar R and Sinha VR | Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir). | 2017 | AAPS PharmSciTech | pmid:27368921 |
| Spaniol B et al. | Compressional behavior of a mixture of granules containing high load of Phyllanthus niruri spray-dried extract and granules of adjuvants: comparison between eccentric and rotary tablet machines. | 2009 | AAPS PharmSciTech | pmid:19662537 |
| Lau M et al. | Investigation into the Manufacture and Properties of Inhalable High-Dose Dry Powders Produced by Comilling API and Lactose with Magnesium Stearate. | 2017 | AAPS PharmSciTech | pmid:28070849 |
| Thotakura N et al. | Chitosan-Stearic Acid Based Polymeric Micelles for the Effective Delivery of Tamoxifen: Cytotoxic and Pharmacokinetic Evaluation. | 2017 | AAPS PharmSciTech | pmid:27287243 |
| Kelidari HR et al. | Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. | 2017 | AAPS PharmSciTech | pmid:27834054 |
| Monajjemzadeh F et al. | Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies. | 2009 | AAPS PharmSciTech | pmid:19455427 |
| Schrank S et al. | Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. | 2012 | AAPS PharmSciTech | pmid:22552931 |
| Ahmed TA et al. | Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. | 2012 | AAPS PharmSciTech | pmid:22585373 |
| Jun HY et al. | Long residence time of ultrasound microbubbles targeted to integrin in murine tumor model. | 2010 | Acad Radiol | pmid:19815430 |
| Yang W et al. | Facile Synthesis of Gd-Cu-In-S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging. | 2015 | ACS Appl Mater Interfaces | pmid:26257133 |
| He M et al. | Controllable stearic acid crystal induced high hydrophobicity on cellulose film surface. | 2013 | ACS Appl Mater Interfaces | pmid:23289586 |
| Rambaut PC and Johnston RS | Prolonged weightlessness and calcium loss in man. | 1979 | Acta Astronaut | pmid:11883480 |
| Marchut E et al. | The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells. | 1986 | Acta Biochim. Pol. | pmid:2940781 |
| Liu TY and Lin YL | Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs. | 2010 | Acta Biomater | pmid:19819354 |
| Nouri A et al. | Effect of process control agent on the porous structure and mechanical properties of a biomedical Ti-Sn-Nb alloy produced by powder metallurgy. | 2010 | Acta Biomater | pmid:19815096 |
| Xing Z et al. | Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate. | 2010 | Acta Biomater | pmid:20226284 |
| Ivanova EP et al. | Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite. | 2017 | Acta Biomater | pmid:28688988 |
| Lundberg B | Thermal properties of systems containing cholesteryl esters and triglycerides. | 1976 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:1266525 |
| Lassus A et al. | Erythromycin and lymecycline treatment in chlamydia-positive and Chlamydia-negative non-gonococcal urethritis--a partner-controlled study. | 1979 | Acta Derm. Venereol. | pmid:87096 |
| MAKLEIT JK et al. | THIN LAYER AND GAS CHROMATOGRAPHIC ANALYSIS OF SYPHILIS ANTIGENS. | 1964-1965 | Acta Microbiol Acad Sci Hung | pmid:14314670 |
| Larsson K and Glantz PO | Microbial adhesion to surfaces with different surface charges. | 1981 | Acta Odontol. Scand. | pmid:6948486 |
| Walstad RA and Hellum KB | Penetration of erythromycin in respiratory tract infections. | 1984 | Acta Otolaryngol Suppl | pmid:6333775 |
| Rosén C et al. | Acute otitis media in older children and adults treated with penicillin or erythromycin. | 1984 | Acta Otolaryngol Suppl | pmid:6437133 |
| Rosén C et al. | Acute otitis media in older children and adults treated with phenoxymethyl penicillin or erythromycin stearate. Bacteriological and immunological aspects. | 1983 Sep-Oct | Acta Otolaryngol. | pmid:6416018 |
| Paavolainen M et al. | Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis. | 1977 Sep-Oct | Acta Otolaryngol. | pmid:199040 |
| Sanjurjo P et al. | Plasma fatty acid composition during the first week of life following feeding with human milk or formula. | 1988 | Acta Paediatr Scand | pmid:3354331 |
| Wadström T et al. | Hydrophobized wound dressing in the treatment of experimental Staphylococcus aureus infections in the young pig. | 1985 | Acta Pathol Microbiol Immunol Scand B | pmid:2417448 |
| BRZIN B | COMPARATIVE STUDIES ON ANAEROBIC CORYNEBACTERIA AND ACTINOMYCETES. | 1965 | Acta Pathol Microbiol Scand | pmid:14322324 |
| Kumar RV and Sinha VR | Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. | 2011 | Acta Pharm | pmid:21945913 |
| MuselÃk J et al. | Influence of process parameters on content uniformity of a low dose active pharmaceutical ingredient in a tablet formulation according to GMP. | 2014 | Acta Pharm | pmid:25296681 |
| Varshosaz J et al. | Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide. | 2012 | Acta Pharm | pmid:22472447 |
| Saroja C and Lakshmi PK | Formulation and optimization of fenofibrate lipospheres using Taguchi's experimental design. | 2013 | Acta Pharm | pmid:23482314 |
| MužÃková J and KubÃÄková A | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride. | 2016 | Acta Pharm | pmid:27383891 |
| Someshwar K et al. | Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride. | 2011 | Acta Pharm | pmid:21684848 |
| Pani NR et al. | Compatibility studies of nateglinide with excipients in immediate release tablets. | 2011 | Acta Pharm | pmid:21684850 |
| Plachy J et al. | In vitro biopharmaceutical test for wetting rate. | 1985 | Acta Pharm Hung | pmid:4050448 |
| Johansson ME | Investigations of the mixing time dependence of the lubricating properties of granular and powdered magnesium stearate. | 1985 | Acta Pharm. Suec. | pmid:3832785 |
| SKOU JC | Local anaesthetics. V. The action of local anaesthetics on monomolecular layers of stearic acid. | 1954 | Acta Pharmacol Toxicol (Copenh) | pmid:14398295 |
| Wang ZJ et al. | Stearic acid protects primary cultured cortical neurons against oxidative stress. | 2007 | Acta Pharmacol. Sin. | pmid:17302992 |
| Zhang XX et al. | Effects of breast cancer resistance protein inhibitors and pharmaceutical excipients on decreasing gastrointestinal toxicity of camptothecin analogs. | 2008 | Acta Pharmacol. Sin. | pmid:18954535 |
| Tierno MA and Brenner RR | [Biochemistry of the developmental cycle of Triatoma infestans (Vinchuca). 2. Biosynthesis of fatty acids]. | 1979 | Acta Physiol Lat Am | pmid:400672 |
| Catalá A | Stearic acid desaturation in rat liver microsomes: stimulation by fatty acid binding protein. | 1986 | Acta Physiol Pharmacol Latinoam | pmid:2876583 |
| Zanetti R and Catalá A | Lipid binding properties of fatty acid binding protein isolated from mouse liver. | 1988 | Acta Physiol Pharmacol Latinoam | pmid:3201993 |
| BLOMSTRAND R et al. | On the intestinal absorption of 2, 2-dimethylstearic acid fed as free acid or as glyceride. | 1956 | Acta Physiol. Scand. | pmid:13339456 |
| GOERANSSON G | THE METABOLISM OF FATTY ACIDS IN THE RAT. IV. STEARIC ACID. | 1965 | Acta Physiol. Scand. | pmid:14321752 |
| Stanisz B | The influence of pharmaceutical excipients on quinapril hydrochloride stability. | 2005 May-Jun | Acta Pol Pharm | pmid:16193811 |
| MuzÃková J and Sináglová P | Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses. | 2013 Jan-Feb | Acta Pol Pharm | pmid:23610968 |
| Hussain T et al. | Effect of two hydrophobic polymers on the release of gliclazide from their matrix tablets. | 2013 Jul-Aug | Acta Pol Pharm | pmid:23923399 |
| Stanisz B et al. | Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. | 2010 Jan-Feb | Acta Pol Pharm | pmid:20210086 |
| MuzÃková J et al. | A study of micronized poloxamers as lubricants in direct compression of tablets. | 2013 Nov-Dec | Acta Pol Pharm | pmid:24383332 |
| Nath B et al. | Preparation and in vitro dissolution profile of zidovudine loaded microspheres made of Eudragit RS 100, RL 100 and their combinations. | 2011 May-Jun | Acta Pol Pharm | pmid:21648196 |
| BozdaÄŸ-Pehlivan S et al. | Evaluation of drug-excipient interaction in the formulation of celecoxib tablets. | 2011 May-Jun | Acta Pol Pharm | pmid:21648198 |
| Kerti A et al. | Content of retinol and retinyl esters in blood plasma, liver, kidney and reproductive organs of Japanese quails. | 2002 | Acta Vet. Hung. | pmid:12498148 |
| Fodorová M et al. | Structural features of lipid A of Rickettsia typhi. | 2011 | Acta Virol. | pmid:21434703 |
| Bertrand G et al. | [The value of polyglactin 910 combined with a resorbable bone wax for filling periodontal bone defects]. | 1985 | Actual Odontostomatol (Paris) | pmid:2425560 |
| Veit M and Thaa B | Association of influenza virus proteins with membrane rafts. | 2011 | Adv Virol | pmid:22312341 |
| Nishioka Y and Yoshino H | Lymphatic targeting with nanoparticulate system. | 2001 | Adv. Drug Deliv. Rev. | pmid:11251245 |
| Jensen RG et al. | Parenteral infusion of a lactating woman with intralipid: changes in milk and plasma fatty acids. | 2001 | Adv. Exp. Med. Biol. | pmid:11787679 |