stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Burns D002056 34 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Liu Q et al. High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing. 2002 Plant Physiol. pmid:12177486
Li C et al. Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathway. 2002 Plant Physiol. pmid:12226528
Okazaki K et al. The significance of C16 fatty acids in the sn-2 positions of glycerolipids in the photosynthetic growth of Synechocystis sp. PCC6803. 2006 Plant Physiol. pmid:16603667
Salzman RA et al. Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses. 2005 Plant Physiol. pmid:15863699
Desbrosses GG et al. Lotus japonicus metabolic profiling. Development of gas chromatography-mass spectrometry resources for the study of plant-microbe interactions. 2005 Plant Physiol. pmid:15749991
Clemente TE and Cahoon EB Soybean oil: genetic approaches for modification of functionality and total content. 2009 Plant Physiol. pmid:19783644
Sorigué D et al. Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. 2016 Plant Physiol. pmid:27288359
Donaldson RP and Beevers H Lipid composition of organelles from germinating castor bean endosperm. 1977 Plant Physiol. pmid:16659829
Pollard MR and Stumpf PK Biosynthesis of C(20) and C(22) Fatty Acids by Developing Seeds of Limnanthes alba: CHAIN ELONGATION AND Delta5 DESATURATION. 1980 Plant Physiol. pmid:16661496
Ashworth EN and Christiansen MN Effect of Temperature and BASF 13 338 on the Lipid Composition and Respiration of Wheat Roots. 1981 Plant Physiol. pmid:16661741
Lem NW and Stumpf PK In Vitro Fatty Acid Synthesis and Complex Lipid Metabolism in the Cyanobacterium, Anabaena Variabilis: II. Acyl Transfer and Complex Lipid Formation. 1984 Plant Physiol. pmid:16663690
Roughan PG Phosphatidylglycerol and chilling sensitivity in plants. 1985 Plant Physiol. pmid:16664127
Bhattacharya S et al. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. 2015 Plant Physiol. Biochem. pmid:26351151
Salas JJ et al. The biochemical characterization of a high-stearic acid sunflower mutant reveals the coordinated regulation of stearoyl-acyl carrier protein desaturases. 2008 Plant Physiol. Biochem. pmid:18023195
Ghosh SK et al. Characterization and cloning of a stearoyl/oleoyl specific fatty acyl-acyl carrier protein thioesterase from the seeds of Madhuca longifolia (latifolia). 2007 Plant Physiol. Biochem. pmid:17977002
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Fernández-Moya V et al. Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. 2003 Planta pmid:12624771
Liu J et al. Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. 2012 Planta pmid:22855030
Su BN et al. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. 2002 Planta Med. pmid:12494342
Dantas da Silva LL et al. Antibacterial activity of a stearic acid derivative from Stemodia foliosa. 2002 Planta Med. pmid:12494347
Kalinina OV et al. Combinations of protein-chemical complex structures reveal new targets for established drugs. 2011 PLoS Comput. Biol. pmid:21573205
Kinnings SL et al. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. 2009 PLoS Comput. Biol. pmid:19578428
Toubiana D et al. Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. 2012 PLoS Genet. pmid:22479206
Milicic A et al. Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. 2012 PLoS ONE pmid:22470545
Mason P et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. 2012 PLoS ONE pmid:22457791
Olivieri C et al. Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. 2012 PLoS ONE pmid:22457789
Paul D et al. Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions. 2011 PLoS ONE pmid:21386900
Sampey BP et al. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. 2012 PLoS ONE pmid:22701716
Schwab U et al. Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. 2008 PLoS ONE pmid:18612464
Chansela P et al. Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry. 2012 PLoS ONE pmid:22432001
D'Ambrosio DN et al. Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage. 2011 PLoS ONE pmid:21949825
Oosterveer MH et al. High fat feeding induces hepatic fatty acid elongation in mice. 2009 PLoS ONE pmid:19557132
Matsui H et al. Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. 2012 PLoS ONE pmid:22413010
Trupp M et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. 2012 PLoS ONE pmid:22808006
Brown JD et al. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. 2011 PLoS ONE pmid:21750705
Fernandez C et al. Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice. 2011 PLoS ONE pmid:21738729
Lim J et al. Solution structures of the acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8. 2011 PLoS ONE pmid:21674045
Ishida Y et al. Fatty acid solubilizer from the oral disk of the blowfly. 2013 PLoS ONE pmid:23326317
Sharma P et al. Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. 2013 PLoS ONE pmid:23326499
Noguchi Y et al. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. 2010 PLoS ONE pmid:20706589
Jung SW et al. Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. 2015 PLoS ONE pmid:25793403
Maher AC et al. Women have higher protein content of beta-oxidation enzymes in skeletal muscle than men. 2010 PLoS ONE pmid:20700461
Shen MC et al. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. 2014 PLoS ONE pmid:25222131
Jin Q et al. A novel cationic microbubble coated with stearic acid-modified polyethylenimine to enhance DNA loading and gene delivery by ultrasound. 2013 PLoS ONE pmid:24086748
Van Hoeck V et al. Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. 2011 PLoS ONE pmid:21858021
Smathers RL et al. Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. 2012 PLoS ONE pmid:22701647
Hellemans KH et al. Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. 2009 PLoS ONE pmid:19787047
Deb C et al. A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. 2009 PLoS ONE pmid:19562030
Bazzini AA et al. Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes. 2011 PLoS ONE pmid:22174812
Wang L et al. Effect of rare Earth ions on the properties of composites composed of ethylene vinyl acetate copolymer and layered double hydroxides. 2012 PLoS ONE pmid:22693627