stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Burns D002056 34 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Wang D et al. One-pot synthesized hierarchical zeolite supported metal nanoparticles for highly efficient biomass conversion. 2015 Chem. Commun. (Camb.) pmid:26361087
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Zhang X et al. Effect of Chemicals on Morphology and Luminescence of CdSe Quantum Dots. 2015 J Nanosci Nanotechnol pmid:26353513
Bhattacharya S et al. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. 2015 Plant Physiol. Biochem. pmid:26351151
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Castellanos-Tapia L et al. Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. 2015 Nutr Res pmid:25727313
Kerth CR et al. Consumer sensory evaluation, fatty acid composition, and shelf-life of ground beef with subcutaneous fat trimmings from different carcass locations. 2015 Meat Sci. pmid:25688688
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Patil PS et al. Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. 2015 Nat Commun pmid:26037164
Onishi H et al. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. 2015 Biol. Pharm. Bull. pmid:26027834
Rehman M et al. Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. 2015 Int J Nanomedicine pmid:25897224
Harding SV et al. Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. 2015 BMC Res Notes pmid:25879456
Silva-Neta IC et al. Expression of genes related to tolerance to low temperature for maize seed germination. 2015 Genet. Mol. Res. pmid:25867416
Ocloo FCK et al. Effects of stearic acid and gamma irradiation, alone and in combination, on pasting properties of high amylose maize starch. 2016 Food Chem pmid:26212935
Jójárt I et al. Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. 2016 Pharm Dev Technol pmid:25673279
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Sun Y et al. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. 2016 J. Lipid Res. pmid:27371261
Du H et al. Modification of the fatty acid composition in Arabidopsis and maize seeds using a stearoyl-acyl carrier protein desaturase-1 (ZmSAD1) gene. 2016 BMC Plant Biol. pmid:27297560
Sorigué D et al. Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. 2016 Plant Physiol. pmid:27288359
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Ma Y et al. Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting. 2016 Molecules pmid:26938513
Šrámek J et al. p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells. 2016 Int J Mol Sci pmid:26861294
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Garba L et al. Heterologous Expression of PA8FAD9 and Functional Characterization of a Δ9-Fatty Acid Desaturase from a Cold-Tolerant Pseudomonas sp. A8. 2016 Mol. Biotechnol. pmid:27629791
Mazel V et al. Reevaluation of the diametral compression test for tablets using the flattened disc geometry. 2016 Int J Pharm pmid:27702696
Nie H et al. Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. 2016 Mol. Pharm. pmid:27542728
Passerini N et al. Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model. 2016 Int J Pharm pmid:27530293
Karthik S et al. Quillaja saponin: A prospective emulsifier for the preparation of solid lipid nanoparticles. 2016 Colloids Surf B Biointerfaces pmid:27521748
Ghate VM et al. Nanostructured lipid carriers for the topical delivery of tretinoin. 2016 Eur J Pharm Biopharm pmid:27519827
Ohiri RC and Bassey EE Gas Chromatography-Mass Spectrometry Analysis of Constituent Oil from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), from Nigeria. 2016 Int J Med Mushrooms pmid:27481303
Monteyne T et al. Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. 2016 Int J Pharm pmid:27452420
Hu Y et al. Sequential delivery of therapeutic agents using a rationally designed disulfide-linked glycolipid-like nanocarrier. 2016 Oncotarget pmid:27825127
Billès E et al. Cellulose oligomers production and separation for the synthesis of new fully bio-based amphiphilic compounds. 2016 Carbohydr Polym pmid:27577903
Krasnou I et al. Permeability of water and oleic acid in composite films of phase separated polypropylene and cellulose stearate blends. 2016 Carbohydr Polym pmid:27516292
Liu L et al. Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation. 2016 Eur J Clin Nutr pmid:26733041
Thilakarathna SH et al. Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. 2016 Food Funct pmid:26961726
Ma F et al. Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid. 2016 Mater Sci Eng C Mater Biol Appl pmid:26952440
Zhang C et al. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. 2016 Int J Pharm pmid:26943975
Zhang Y et al. CO2/pH-Controllable Viscoelastic Nanostructured Fluid Based on Stearic Acid Soap and Bola-Type Quaternary Ammonium Salt. 2016 Langmuir pmid:26907546
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Lohan SB et al. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-multi-shell (CMS) nanocarriers. 2016 Int J Pharm pmid:26853315
Stahlberg S et al. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. 2016 Langmuir pmid:26828109
Lavergne SN et al. Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. 2016 Vet. Dermatol. pmid:26748887
Baig MS et al. Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity. 2016 Int. J. Biol. Macromol. pmid:26740466
Adler C et al. Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion. 2016 Int J Pharm pmid:26721729