| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Nathanson MH et al. | Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. | 1999 | Gastroenterology | pmid:10220510 |
| Guo Y et al. | Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid. | 1999 | Am. J. Physiol. | pmid:10362727 |
| Griffith TM and Taylor HJ | Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486252 |
| Bertuzzi F et al. | Mechanisms of coordination of Ca2+ signals in pancreatic islet cells. | 1999 | Diabetes | pmid:10512361 |
| Chaytor AT et al. | The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. | 1999 | J. Physiol. (Lond.) | pmid:10523421 |
| Princen F et al. | A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect. | 1999 | Clin. Cancer Res. | pmid:10589781 |
| Yu J et al. | Gap junction uncouplers attenuate arteriolar response to distal capillary stimuli. | 2000 | Microvasc. Res. | pmid:10625583 |
| White R and Hiley CR | Hyperpolarisation of rat mesenteric endothelial cells by ATP-sensitive K(+) channel openers. | 2000 | Eur. J. Pharmacol. | pmid:10844125 |
| Reuss B et al. | Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2. | 2000 | Mol. Cell. Neurosci. | pmid:10882482 |
| Bannerman P et al. | Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. | 2000 | J. Neurosci. Res. | pmid:10972957 |
| Doughty JM et al. | Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium. | 2001 | Br. J. Pharmacol. | pmid:11156589 |
| Jiang F and Dusting GJ | Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats. | 2001 | Br. J. Pharmacol. | pmid:11264250 |
| Ruiz-Meana M et al. | Persistence of gap junction communication during myocardial ischemia. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356611 |
| Romanello M and D'Andrea P | Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels. | 2001 | J. Bone Miner. Res. | pmid:11499869 |
| Shah US and Murray SA | Bimodal inhibition of connexin 43 gap junctions decreases ACTH-induced steroidogenesis and increases bovine adrenal cell population growth. | 2001 | J. Endocrinol. | pmid:11572804 |
| Scotland RS et al. | An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. | 2001 | Hypertension | pmid:11641295 |
| Contreras JE et al. | Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11756680 |
| Matoba T et al. | Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11798159 |
| Goto K et al. | Critical role of gap junctions in endothelium-dependent hyperpolarization in rat mesenteric arteries. | 2002 | Clin. Exp. Pharmacol. Physiol. | pmid:12060103 |
| Kenny LC et al. | The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women. | 2002 | Br. J. Pharmacol. | pmid:12163339 |
| Zhang W et al. | Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication. | 2002 | J. Cell. Physiol. | pmid:12385001 |
| Lagaud G et al. | Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12427590 |
| Solomon IC et al. | Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat. | 2003 | J. Neurophysiol. | pmid:12522166 |
| Ransjö M et al. | Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684060 |
| Ye ZC et al. | Functional hemichannels in astrocytes: a novel mechanism of glutamate release. | 2003 | J. Neurosci. | pmid:12736329 |
| Sung YJ et al. | Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. | 2003 | Exp. Cell Res. | pmid:12837277 |
| El-Sabban ME et al. | ECM-induced gap junctional communication enhances mammary epithelial cell differentiation. | 2003 | J. Cell. Sci. | pmid:12893812 |
| Thust R et al. | Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells. | 2004 | Mutagenesis | pmid:14681310 |
| De Blasio BF et al. | Global, synchronous oscillations in cytosolic calcium and adherence in bradykinin-stimulated Madin-Darby canine kidney cells. | 2004 | Acta Physiol. Scand. | pmid:15030375 |
| Fujino H and Regan JW | Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15094384 |
| Seul KH et al. | Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15194487 |
| Guillotin B et al. | Human primary endothelial cells stimulate human osteoprogenitor cell differentiation. | 2004 | Cell. Physiol. Biochem. | pmid:15319536 |
| Gumpricht E et al. | Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. | 2005 | J. Biol. Chem. | pmid:15642733 |
| RodrÃguez-Sinovas A et al. | Protective effect of gap junction uncouplers given during hypoxia against reoxygenation injury in isolated rat hearts. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16183732 |
| Garg S et al. | Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia. | 2005 | J. Neurochem. | pmid:16190870 |
| Shamekh R et al. | The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor. | 2006 | Exp Brain Res | pmid:16328273 |
| Perez Velazquez JL et al. | Role of gap junctional coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress and hippocampal damage. | 2006 | Eur. J. Neurosci. | pmid:16420410 |
| Luna VM and Brehm P | An electrically coupled network of skeletal muscle in zebrafish distributes synaptic current. | 2006 | J. Gen. Physiol. | pmid:16801383 |
| Miyazato M et al. | A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction. | 2006 | Biomed. Res. | pmid:17099284 |
| Kamijo M et al. | The function of connexin 43 on the differentiation of rat bone marrow cells in culture. | 2006 | Biomed. Res. | pmid:17213685 |
| Kamioka H et al. | Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts. | 2007 | Microsc. Microanal. | pmid:17367550 |
| Lin D et al. | Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. | 2007 | Exp. Eye Res. | pmid:17493614 |
| Guan BC et al. | Blockade of gap junction coupling by glycyrrhetinic acids in guinea pig cochlear artery: a whole-cell voltage- and current-clamp study. | 2007 | Br. J. Pharmacol. | pmid:17572704 |
| Ikeda Y et al. | Role of gap junctions in spontaneous activity of the rat bladder. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17581924 |
| Lang RJ et al. | Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis. | 2007 | J. Physiol. (Lond.) | pmid:17656432 |
| Yamamoto Y et al. | Role of gap junctions and protein kinase A during the development of oocyte maturational competence in Ayu (Plecoglossus altivelis). | 2008 | Gen. Comp. Endocrinol. | pmid:17964574 |
| Yamanouchi K et al. | 18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. | 2007 | Cell. Physiol. Biochem. | pmid:17982260 |
| Luksha L et al. | Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18032472 |
| Kansui Y et al. | Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries. | 2008 | Cell Calcium | pmid:18191200 |
| Chadjichristos CE et al. | Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells. | 2008 | Circ. Res. | pmid:18239136 |
| Wu X et al. | Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. | 2008 | Hepatology | pmid:18452148 |
| Miguel-Hidalgo J et al. | Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats. | 2009 | J. Psychopharmacol. (Oxford) | pmid:18562436 |
| Lee CS et al. | 18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity. | 2008 | Life Sci. | pmid:18721818 |
| Velasquez Almonacid LA et al. | Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica. | 2009 | Vet. J. | pmid:18824377 |
| Ye ZC et al. | Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. | 2009 | Glia | pmid:18837047 |
| Ciovacco WA et al. | The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. | 2009 | Bone | pmid:18848655 |
| Zou Q et al. | Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics. | 2009 | Biomed. Chromatogr. | pmid:18850581 |
| Verma V et al. | Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins. | 2009 | Eur. J. Cell Biol. | pmid:18951659 |
| Nejime N et al. | Possible participation of chloride ion channels in ATP release from cancer cells in suspension. | 2009 | Clin. Exp. Pharmacol. Physiol. | pmid:18986334 |
| Pellati D et al. | In vitro effects of glycyrrhetinic acid on the growth of clinical isolates of Candida albicans. | 2009 | Phytother Res | pmid:19067381 |
| Ming J et al. | Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats. | 2009 | Shock | pmid:19077877 |
| Clarke TC et al. | ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide. | 2009 | Eur. J. Pharmacol. | pmid:19101539 |
| Kao TC et al. | Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. | 2009 | J. Agric. Food Chem. | pmid:19105645 |
| Sato T et al. | Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog. | 2009 | Cell. Mol. Neurobiol. | pmid:19145483 |
| Li WC et al. | Locomotor rhythm maintenance: electrical coupling among premotor excitatory interneurons in the brainstem and spinal cord of young Xenopus tadpoles. | 2009 | J. Physiol. (Lond.) | pmid:19221124 |
| Kim DE et al. | Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change. | 2009 | Neurochem. Res. | pmid:19224363 |
| Kalaiarasi P et al. | Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats. | 2009 | Eur. J. Pharmacol. | pmid:19361497 |
| Kalaiarasi P and Pugalendi KV | Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. | 2009 | Eur. J. Pharmacol. | pmid:19374864 |
| Iqbal Choudhary M et al. | Microbial transformation of 18beta-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products. | 2009 | Nat. Prod. Res. | pmid:19384727 |
| Kaneda M et al. | Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes. | 2009 | Biomaterials | pmid:19423159 |
| Classen-Houben D et al. | Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19429429 |
| Trepel M et al. | A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer. | 2009 | Mol. Cancer Ther. | pmid:19671758 |
| He B et al. | Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions. | 2009 | Clin. Cancer Res. | pmid:19723651 |
| Verwey LJ and Edwards TM | Gap junctions and memory: an investigation using a single trial discrimination avoidance task for the neonate chick. | 2010 | Neurobiol Learn Mem | pmid:19796702 |
| Kawakami Z et al. | Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes. | 2010 | Eur. J. Pharmacol. | pmid:19818347 |
| Xiao Y et al. | 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. | 2010 | J. Biol. Chem. | pmid:19897483 |
| Kapeta S et al. | Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. | 2010 | J. Biol. Chem. | pmid:20068043 |
| Plotnikov EY et al. | Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture. | 2010 | Exp. Cell Res. | pmid:20599955 |
| Kao TC et al. | Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. | 2010 | J. Agric. Food Chem. | pmid:20681651 |
| Sasaki H et al. | 18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice. | 2010 | J. Periodont. Res. | pmid:20682015 |
| Song D et al. | Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+]. | 2010 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:20705586 |
| Dey A et al. | Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland. | 2010 | Br. J. Pharmacol. | pmid:20735413 |
| Geddawy A et al. | Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery. | 2010 | J. Pharmacol. Sci. | pmid:20838025 |
| Lee CS et al. | 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. | 2010 | Eur. J. Pharmacol. | pmid:20868669 |
| Li WC et al. | Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors. | 2010 | J. Neurosci. | pmid:21148000 |
| Piao H et al. | Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. | 2011 | Clin. Exp. Nephrol. | pmid:21153751 |
| Li XD et al. | Panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities. | 2010 | Cell. Physiol. Biochem. | pmid:21220939 |
| Sun W et al. | Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid. | 2011 | Chem Biol Drug Des | pmid:21244638 |
| Cavone L et al. | 18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis. | 2011 | Ocul. Immunol. Inflamm. | pmid:21426233 |
| Shetty AV et al. | 18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. | 2011 | Int. J. Oncol. | pmid:21637916 |
| Wang CY et al. | Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. | 2011 | J. Agric. Food Chem. | pmid:21644799 |
| Zhou X et al. | Antimycobacterial and synergistic effects of 18β-glycyrrhetinic acid or glycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis. | 2012 | Phytother Res | pmid:21656601 |
| Zhao K et al. | Inhibition of gap junction channel attenuates the migration of breast cancer cells. | 2012 | Mol. Biol. Rep. | pmid:21674188 |
| Lin KW et al. | 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. | 2011 | Bioorg. Med. Chem. | pmid:21696969 |
| Sharma G et al. | 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. | 2012 | J. Cell. Physiol. | pmid:21732363 |
| Veratti E et al. | 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. | 2011 | Anticancer Res. | pmid:21737643 |
| Yu J et al. | Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures. | 2011 | Mol. Cell. Endocrinol. | pmid:21767601 |
| Kim SJ et al. | Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. | 2011 | Urology | pmid:21820587 |
| Lee J et al. | Gap junctions contribute to astrocytic resistance against zinc toxicity. | 2011 | Brain Res. Bull. | pmid:21884763 |
18alpha-glycyrrhetinic acid
18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.
Cross Reference
Introduction
To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 18alpha-glycyrrhetinic acid?
18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 18alpha-glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with 18alpha-glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.