| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hung CF et al. | 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. | 2017 | PLoS ONE | pmid:28813533 |
| Suswillo RF et al. | Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. | 2017 | Cell Biochem. Funct. | pmid:28083967 |
| Zhu Y et al. | Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. | 2016 | Cell Metab. | pmid:27626200 |
| Queiroga CS et al. | Paracrine effect of carbon monoxide - astrocytes promote neuroprotection through purinergic signaling in mice. | 2016 | J. Cell. Sci. | pmid:27383770 |
| Huang YC et al. | 18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways. | 2016 | Molecules | pmid:27376261 |
| Ikarashi Y and Mizoguchi K | Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. | 2016 | Pharmacol. Ther. | pmid:27373856 |
| Yu J et al. | Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. | 2016 | Endocrinology | pmid:27035651 |
| Cao D et al. | The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. | 2016 | Biomed Res Int | pmid:27006947 |
| Li SN et al. | Effect of Connexin43 on Mechanical Tension-stimulated Osteogenic Transcription Factors of Human Periodontal Ligament Fibroblasts. | 2016 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:26956851 |
| Papaevgeniou N et al. | 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. | 2016 | Antioxid. Redox Signal. | pmid:26886723 |
| Yamada A et al. | Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. | 2016 | J. Biol. Chem. | pmid:26565022 |
| Takeuchi R et al. | Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth. | 2016 | Br. J. Pharmacol. | pmid:26676684 |
| Zhou J et al. | 18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination. | 2015 | Sci Rep | pmid:26329786 |
| Zhang H et al. | Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor. | 2015 | Acta Pharmacol. Sin. | pmid:26279158 |
| Kitagawa H et al. | Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study. | 2015 | PLoS ONE | pmid:26151135 |
| Qu Y et al. | Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis. | 2015 | Int J Clin Exp Pathol | pmid:25973013 |
| Gupta P et al. | Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation. | 2015 | Antimicrob. Agents Chemother. | pmid:25691644 |
| Kuzma-Kuzniarska M et al. | Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching. | 2014 | J Biomed Opt | pmid:24390370 |
| Jayasooriya RG et al. | 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway. | 2014 | Toxicol In Vitro | pmid:24613819 |
| Akopian A et al. | Gap junction-mediated death of retinal neurons is connexin and insult specific: a potential target for neuroprotection. | 2014 | J. Neurosci. | pmid:25100592 |
| Kim YJ et al. | Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells. | 2014 | Cell. Mol. Life Sci. | pmid:24623558 |
| Li X et al. | Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24380838 |
| Hendricks JM et al. | Differential induction of isolated lymphoid follicles in the gut by 18β-glycyrrhetinic acid. | 2014 | PLoS ONE | pmid:24992099 |
| Zhang W et al. | [Inhibitory effect of 18β-glycyrrhetinic acid on KCl- and PE-induced constriction of rat renal interlobar artery in vitro]. | 2014 | Sheng Li Xue Bao | pmid:24777410 |
| Mizoguchi K et al. | Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain. | 2014 | PLoS ONE | pmid:24752617 |
| Huang RY et al. | 18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer. | 2014 | PLoS ONE | pmid:24695790 |
| Jay M et al. | Effects of nitric oxide on neuromuscular properties of developing zebrafish embryos. | 2014 | PLoS ONE | pmid:24489806 |
| Wong PS et al. | Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? | 2014 | Br. J. Pharmacol. | pmid:24467384 |
| Yadav DK et al. | Design, synthesis and in vitro evaluation of 18β-glycyrrhetinic acid derivatives for anticancer activity against human breast cancer cell line MCF-7. | 2014 | Curr. Med. Chem. | pmid:24180274 |
| Wang D et al. | 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. | 2014 | J. Neurooncol. | pmid:24162829 |
| Feng Yeh C et al. | Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. | 2013 | J Ethnopharmacol | pmid:23643542 |
| Kao TC et al. | Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation. | 2013 | Phytomedicine | pmid:23218403 |
| Kato R et al. | Gap-junction-mediated communication in human periodontal ligament cells. | 2013 | J. Dent. Res. | pmid:23677649 |
| Kuang P et al. | 18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. | 2013 | Int. J. Cancer | pmid:22991231 |
| Nishida S and Satoh H | Role of gap junction involved with endothelium-derived hyperpolarizing factor for the quercetin-induced vasodilatation in rat mesenteric artery. | 2013 | Life Sci. | pmid:23435092 |
| Kim ME et al. | 18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses. | 2013 | Immunopharmacol Immunotoxicol | pmid:23438306 |
| Figueroa XF et al. | Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels. | 2013 | Neuropharmacology | pmid:23499665 |
| Ishida T et al. | Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice. | 2013 | Eur. J. Pharmacol. | pmid:23792039 |
| Chen H et al. | Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. | 2013 | Mol Nutr Food Res | pmid:23322474 |
| Zong L et al. | 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. | 2013 | J Dig Dis | pmid:23362936 |
| Lallemand B et al. | Synthesis and plasma pharmacokinetics in CD-1 mice of a 18β-glycyrrhetinic acid derivative displaying anti-cancer activity. | 2013 | J. Pharm. Pharmacol. | pmid:23356849 |
| Long DR et al. | 18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. | 2013 | Antimicrob. Agents Chemother. | pmid:23114775 |
| Kim J et al. | 18β-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract. | 2013 | Phytomedicine | pmid:23746951 |
| Fu XX et al. | 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells. | 2013 | J Ethnopharmacol | pmid:23707333 |
| Kizub IV et al. | Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization. | 2013 | Cardiovasc. Res. | pmid:23708740 |
| Nomura R et al. | Bee venom phospholipase A2-induced phasic contractions in mouse rectum: independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis. | 2013 | Eur. J. Pharmacol. | pmid:24012929 |
| Lee KW and Ho WS | 18β-glycyrrhetinic acid induces UDP-glucuronosyltransferase in rats. | 2013 | Protein Pept. Lett. | pmid:24261979 |
| Kalani K et al. | In silico and in vivo anti-malarial studies of 18β glycyrrhetinic acid from Glycyrrhiza glabra. | 2013 | PLoS ONE | pmid:24086367 |
| Hardy ME et al. | 18β-glycyrrhetinic acid inhibits rotavirus replication in culture. | 2012 | Virol. J. | pmid:22616823 |
| Tabuchi M et al. | The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. | 2012 | Cell. Mol. Neurobiol. | pmid:22488528 |
| Zhao K et al. | Inhibition of gap junction channel attenuates the migration of breast cancer cells. | 2012 | Mol. Biol. Rep. | pmid:21674188 |
| Zhou X et al. | Antimycobacterial and synergistic effects of 18β-glycyrrhetinic acid or glycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis. | 2012 | Phytother Res | pmid:21656601 |
| Matsumoto T et al. | The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells. | 2012 | Eur. J. Pharmacol. | pmid:22542662 |
| Niger C et al. | ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22277757 |
| Suh HN et al. | Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex. | 2012 | Stem Cells Dev. | pmid:22150760 |
| Puchner A et al. | Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. | 2012 | Wien. Klin. Wochenschr. | pmid:22210441 |
| Boengler K et al. | Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. | 2012 | J. Cell. Mol. Med. | pmid:22212640 |
| Zong L et al. | 18α-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Β1/Smad signaling pathway in human and rat hepatic stellate cells. | 2012 | Int J Med Sci | pmid:22811611 |
| Goerke SM et al. | Human endothelial progenitor cells induce extracellular signal-regulated kinase-dependent differentiation of mesenchymal stem cells into smooth muscle cells upon cocultivation. | 2012 | Tissue Eng Part A | pmid:22731749 |
| Moon MH et al. | 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22465130 |
| Fujiwara H et al. | Endothelium-derived relaxing factor-mediated vasodilation in mouse mesenteric vascular beds. | 2012 | J. Pharmacol. Sci. | pmid:22450195 |
| Shahidullah M et al. | TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22492652 |
| Li L et al. | Myoendothelial coupling is unidirectional in guinea pig spiral modiolar arteries. | 2012 | Microvasc. Res. | pmid:22580342 |
| Yang JC et al. | 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. | 2012 | Mol. Cell. Biochem. | pmid:22865487 |
| Li S et al. | A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy. | 2012 | Skin Pharmacol Physiol | pmid:22832704 |
| Hong X et al. | Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin. | 2012 | Cancer Lett. | pmid:22115964 |
| Cirillo N et al. | Characterization of a novel oral glucocorticoid system and its possible role in disease. | 2012 | J. Dent. Res. | pmid:22067259 |
| Hendricks JM et al. | 18β-glycyrrhetinic acid delivered orally induces isolated lymphoid follicle maturation at the intestinal mucosa and attenuates rotavirus shedding. | 2012 | PLoS ONE | pmid:23152913 |
| Liu Y et al. | Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23122524 |
| Sharma G et al. | 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. | 2012 | J. Cell. Physiol. | pmid:21732363 |
| Alderman SL and Vijayan MM | 11β-Hydroxysteroid dehydrogenase type 2 in zebrafish brain: a functional role in hypothalamus-pituitary-interrenal axis regulation. | 2012 | J. Endocrinol. | pmid:23042946 |
| Du YM et al. | 18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels. | 2012 | Acta Pharmacol. Sin. | pmid:22609834 |
| Lin KW et al. | 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. | 2011 | Bioorg. Med. Chem. | pmid:21696969 |
| Shetty AV et al. | 18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. | 2011 | Int. J. Oncol. | pmid:21637916 |
| Cavone L et al. | 18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis. | 2011 | Ocul. Immunol. Inflamm. | pmid:21426233 |
| Sun W et al. | Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid. | 2011 | Chem Biol Drug Des | pmid:21244638 |
| Piao H et al. | Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. | 2011 | Clin. Exp. Nephrol. | pmid:21153751 |
| Kim SJ et al. | Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. | 2011 | Urology | pmid:21820587 |
| Wang CY et al. | Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. | 2011 | J. Agric. Food Chem. | pmid:21644799 |
| Ma KT et al. | [18β-glycyrrhetinic acid inhibits outward current of vascular smooth muscle cells of arterioles]. | 2011 | Sheng Li Xue Bao | pmid:22193450 |
| Ukil A et al. | Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. | 2011 | PLoS ONE | pmid:22194991 |
| Veratti E et al. | 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. | 2011 | Anticancer Res. | pmid:21737643 |
| Yu J et al. | Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures. | 2011 | Mol. Cell. Endocrinol. | pmid:21767601 |
| Autsavapromporn N et al. | Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells. | 2011 | J. Radiat. Res. | pmid:21905305 |
| Lee J et al. | Gap junctions contribute to astrocytic resistance against zinc toxicity. | 2011 | Brain Res. Bull. | pmid:21884763 |
| Dey A et al. | Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland. | 2010 | Br. J. Pharmacol. | pmid:20735413 |
| Song D et al. | Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+]. | 2010 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:20705586 |
| Sasaki H et al. | 18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice. | 2010 | J. Periodont. Res. | pmid:20682015 |
| Li WC et al. | Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors. | 2010 | J. Neurosci. | pmid:21148000 |
| Geddawy A et al. | Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery. | 2010 | J. Pharmacol. Sci. | pmid:20838025 |
| Kao TC et al. | Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. | 2010 | J. Agric. Food Chem. | pmid:20681651 |
| Verwey LJ and Edwards TM | Gap junctions and memory: an investigation using a single trial discrimination avoidance task for the neonate chick. | 2010 | Neurobiol Learn Mem | pmid:19796702 |
| Xiao Y et al. | 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. | 2010 | J. Biol. Chem. | pmid:19897483 |
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18alpha-glycyrrhetinic acid
18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.
Cross Reference
Introduction
To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 18alpha-glycyrrhetinic acid?
18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 18alpha-glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with 18alpha-glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.