18alpha-glycyrrhetinic acid

18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 18alpha-glycyrrhetinic acid?

18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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PubChem Associated disorders and diseases

What pathways are associated with 18alpha-glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with 18alpha-glycyrrhetinic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

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All references with 18alpha-glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Kao TC et al. Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. 2010 J. Agric. Food Chem. pmid:20681651
Wang CY et al. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. 2011 J. Agric. Food Chem. pmid:21644799
Kao TC et al. Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. 2009 J. Agric. Food Chem. pmid:19105645
Feng Yeh C et al. Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. 2013 J Ethnopharmacol pmid:23643542
Fu XX et al. 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells. 2013 J Ethnopharmacol pmid:23707333
Zong L et al. 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. 2013 J Dig Dis pmid:23362936
Kuzma-Kuzniarska M et al. Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching. 2014 J Biomed Opt pmid:24390370
Shetty AV et al. 18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. 2011 Int. J. Oncol. pmid:21637916
Kuang P et al. 18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. 2013 Int. J. Cancer pmid:22991231
Zong L et al. 18α-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Β1/Smad signaling pathway in human and rat hepatic stellate cells. 2012 Int J Med Sci pmid:22811611
Qu Y et al. Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis. 2015 Int J Clin Exp Pathol pmid:25973013
Kim ME et al. 18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses. 2013 Immunopharmacol Immunotoxicol pmid:23438306
Scotland RS et al. An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. 2001 Hypertension pmid:11641295
Wu X et al. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. 2008 Hepatology pmid:18452148
Ye ZC et al. Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. 2009 Glia pmid:18837047
Yamamoto Y et al. Role of gap junctions and protein kinase A during the development of oocyte maturational competence in Ayu (Plecoglossus altivelis). 2008 Gen. Comp. Endocrinol. pmid:17964574
Nathanson MH et al. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. 1999 Gastroenterology pmid:10220510
Lin D et al. Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. 2007 Exp. Eye Res. pmid:17493614
Plotnikov EY et al. Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture. 2010 Exp. Cell Res. pmid:20599955
Sung YJ et al. Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. 2003 Exp. Cell Res. pmid:12837277