18alpha-glycyrrhetinic acid

18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 18alpha-glycyrrhetinic acid?

18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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PubChem Associated disorders and diseases

What pathways are associated with 18alpha-glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with 18alpha-glycyrrhetinic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

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All references with 18alpha-glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Sasaki H et al. 18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice. 2010 J. Periodont. Res. pmid:20682015
Song D et al. Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+]. 2010 Acta Biochim. Biophys. Sin. (Shanghai) pmid:20705586
Dey A et al. Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland. 2010 Br. J. Pharmacol. pmid:20735413
Geddawy A et al. Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery. 2010 J. Pharmacol. Sci. pmid:20838025
Lee CS et al. 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. 2010 Eur. J. Pharmacol. pmid:20868669
Li WC et al. Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors. 2010 J. Neurosci. pmid:21148000
Piao H et al. Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. 2011 Clin. Exp. Nephrol. pmid:21153751
Li XD et al. Panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities. 2010 Cell. Physiol. Biochem. pmid:21220939
Sun W et al. Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid. 2011 Chem Biol Drug Des pmid:21244638
Cavone L et al. 18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis. 2011 Ocul. Immunol. Inflamm. pmid:21426233
Shetty AV et al. 18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. 2011 Int. J. Oncol. pmid:21637916
Wang CY et al. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. 2011 J. Agric. Food Chem. pmid:21644799
Zhou X et al. Antimycobacterial and synergistic effects of 18β-glycyrrhetinic acid or glycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis. 2012 Phytother Res pmid:21656601
Zhao K et al. Inhibition of gap junction channel attenuates the migration of breast cancer cells. 2012 Mol. Biol. Rep. pmid:21674188
Lin KW et al. 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. 2011 Bioorg. Med. Chem. pmid:21696969
Sharma G et al. 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. 2012 J. Cell. Physiol. pmid:21732363
Veratti E et al. 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. 2011 Anticancer Res. pmid:21737643
Yu J et al. Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures. 2011 Mol. Cell. Endocrinol. pmid:21767601
Kim SJ et al. Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. 2011 Urology pmid:21820587
Lee J et al. Gap junctions contribute to astrocytic resistance against zinc toxicity. 2011 Brain Res. Bull. pmid:21884763