18alpha-glycyrrhetinic acid

18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 18alpha-glycyrrhetinic acid?

18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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PubChem Associated disorders and diseases

What pathways are associated with 18alpha-glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with 18alpha-glycyrrhetinic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

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All references with 18alpha-glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
White R and Hiley CR Hyperpolarisation of rat mesenteric endothelial cells by ATP-sensitive K(+) channel openers. 2000 Eur. J. Pharmacol. pmid:10844125
Kalaiarasi P et al. Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats. 2009 Eur. J. Pharmacol. pmid:19361497
Clarke TC et al. ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide. 2009 Eur. J. Pharmacol. pmid:19101539
Matsumoto T et al. The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells. 2012 Eur. J. Pharmacol. pmid:22542662
Lee CS et al. 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. 2010 Eur. J. Pharmacol. pmid:20868669
Kalaiarasi P and Pugalendi KV Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. 2009 Eur. J. Pharmacol. pmid:19374864
Ishida T et al. Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice. 2013 Eur. J. Pharmacol. pmid:23792039
Nomura R et al. Bee venom phospholipase A2-induced phasic contractions in mouse rectum: independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis. 2013 Eur. J. Pharmacol. pmid:24012929
Shamekh R et al. The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor. 2006 Exp Brain Res pmid:16328273
Plotnikov EY et al. Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture. 2010 Exp. Cell Res. pmid:20599955
Sung YJ et al. Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. 2003 Exp. Cell Res. pmid:12837277
Lin D et al. Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. 2007 Exp. Eye Res. pmid:17493614
Nathanson MH et al. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. 1999 Gastroenterology pmid:10220510
Yamamoto Y et al. Role of gap junctions and protein kinase A during the development of oocyte maturational competence in Ayu (Plecoglossus altivelis). 2008 Gen. Comp. Endocrinol. pmid:17964574
Ye ZC et al. Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. 2009 Glia pmid:18837047
Wu X et al. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. 2008 Hepatology pmid:18452148
Scotland RS et al. An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. 2001 Hypertension pmid:11641295
Kim ME et al. 18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses. 2013 Immunopharmacol Immunotoxicol pmid:23438306
Qu Y et al. Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis. 2015 Int J Clin Exp Pathol pmid:25973013
Zong L et al. 18α-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Β1/Smad signaling pathway in human and rat hepatic stellate cells. 2012 Int J Med Sci pmid:22811611