18alpha-glycyrrhetinic acid

18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 18alpha-glycyrrhetinic acid?

18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with 18alpha-glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with 18alpha-glycyrrhetinic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 18alpha-glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

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All references with 18alpha-glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Kuang P et al. 18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. 2013 Int. J. Cancer pmid:22991231
Shetty AV et al. 18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. 2011 Int. J. Oncol. pmid:21637916
Kuzma-Kuzniarska M et al. Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching. 2014 J Biomed Opt pmid:24390370
Zong L et al. 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. 2013 J Dig Dis pmid:23362936
Feng Yeh C et al. Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. 2013 J Ethnopharmacol pmid:23643542
Fu XX et al. 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells. 2013 J Ethnopharmacol pmid:23707333
Kao TC et al. Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. 2010 J. Agric. Food Chem. pmid:20681651
Wang CY et al. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. 2011 J. Agric. Food Chem. pmid:21644799
Kao TC et al. Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. 2009 J. Agric. Food Chem. pmid:19105645
Yamada A et al. Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. 2016 J. Biol. Chem. pmid:26565022
Gumpricht E et al. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. 2005 J. Biol. Chem. pmid:15642733
Xiao Y et al. 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. 2010 J. Biol. Chem. pmid:19897483
Kapeta S et al. Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. 2010 J. Biol. Chem. pmid:20068043
Romanello M and D'Andrea P Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels. 2001 J. Bone Miner. Res. pmid:11499869
Boengler K et al. Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. 2012 J. Cell. Mol. Med. pmid:22212640
Zhang W et al. Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication. 2002 J. Cell. Physiol. pmid:12385001
Sharma G et al. 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. 2012 J. Cell. Physiol. pmid:21732363
Queiroga CS et al. Paracrine effect of carbon monoxide - astrocytes promote neuroprotection through purinergic signaling in mice. 2016 J. Cell. Sci. pmid:27383770
El-Sabban ME et al. ECM-induced gap junctional communication enhances mammary epithelial cell differentiation. 2003 J. Cell. Sci. pmid:12893812
Kato R et al. Gap-junction-mediated communication in human periodontal ligament cells. 2013 J. Dent. Res. pmid:23677649