| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:28838831 | ||||
| pmid:28797028 | ||||
| pmid:28768154 | ||||
| pmid:28410469 | ||||
| pmid:28369869 | ||||
| pmid:27499091 | ||||
| pmid:27747446 | ||||
| pmid:27520483 | ||||
| pmid:27161375 | ||||
| pmid:27116616 | ||||
| pmid:27018762 | ||||
| pmid:26965146 | ||||
| pmid:26928299 | ||||
| pmid:26900660 | ||||
| pmid:26780691 | ||||
| pmid:26010440 | ||||
| pmid:25786503 | ||||
| pmid:25498537 | ||||
| pmid:25475507 | ||||
| pmid:25027936 | ||||
| pmid:24824709 | ||||
| pmid:24753074 | ||||
| pmid:24724781 | ||||
| pmid:24612785 | ||||
| pmid:24554419 | ||||
| pmid:24350605 | ||||
| pmid:23675978 | ||||
| pmid:29098529 | ||||
| pmid:22077323 | ||||
| pmid:28513236 | ||||
| pmid:28475285 | ||||
| pmid:27713126 | ||||
| pmid:27145860 | ||||
| pmid:25625661 | ||||
| pmid:24687644 | ||||
| pmid:25652184 | ||||
| pmid:28414158 | ||||
| pmid: | ||||
| Song D et al. | Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+]. | 2010 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:20705586 |
| Zhang H et al. | Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor. | 2015 | Acta Pharmacol. Sin. | pmid:26279158 |
| Du YM et al. | 18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels. | 2012 | Acta Pharmacol. Sin. | pmid:22609834 |
| De Blasio BF et al. | Global, synchronous oscillations in cytosolic calcium and adherence in bradykinin-stimulated Madin-Darby canine kidney cells. | 2004 | Acta Physiol. Scand. | pmid:15030375 |
| Guo Y et al. | Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid. | 1999 | Am. J. Physiol. | pmid:10362727 |
| Ruiz-Meana M et al. | Persistence of gap junction communication during myocardial ischemia. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356611 |
| RodrÃguez-Sinovas A et al. | Protective effect of gap junction uncouplers given during hypoxia against reoxygenation injury in isolated rat hearts. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16183732 |
| Lagaud G et al. | Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12427590 |
| Luksha L et al. | Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18032472 |
| Ikeda Y et al. | Role of gap junctions in spontaneous activity of the rat bladder. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17581924 |
| Niger C et al. | ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22277757 |
| Shahidullah M et al. | TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22492652 |
| Veratti E et al. | 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. | 2011 | Anticancer Res. | pmid:21737643 |
| Gupta P et al. | Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation. | 2015 | Antimicrob. Agents Chemother. | pmid:25691644 |
| Long DR et al. | 18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. | 2013 | Antimicrob. Agents Chemother. | pmid:23114775 |
| Papaevgeniou N et al. | 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. | 2016 | Antioxid. Redox Signal. | pmid:26886723 |
| Seul KH et al. | Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15194487 |
| Fujino H and Regan JW | Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15094384 |
| Ransjö M et al. | Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684060 |
| Griffith TM and Taylor HJ | Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486252 |
| Matoba T et al. | Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11798159 |
| Moon MH et al. | 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22465130 |
| Kaneda M et al. | Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes. | 2009 | Biomaterials | pmid:19423159 |
| Cao D et al. | The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. | 2016 | Biomed Res Int | pmid:27006947 |
| Zou Q et al. | Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics. | 2009 | Biomed. Chromatogr. | pmid:18850581 |
| Miyazato M et al. | A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction. | 2006 | Biomed. Res. | pmid:17099284 |
| Kamijo M et al. | The function of connexin 43 on the differentiation of rat bone marrow cells in culture. | 2006 | Biomed. Res. | pmid:17213685 |
| Lin KW et al. | 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. | 2011 | Bioorg. Med. Chem. | pmid:21696969 |
| Liu Y et al. | Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23122524 |
| Ciovacco WA et al. | The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. | 2009 | Bone | pmid:18848655 |
| Dey A et al. | Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland. | 2010 | Br. J. Pharmacol. | pmid:20735413 |
| Kenny LC et al. | The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women. | 2002 | Br. J. Pharmacol. | pmid:12163339 |
| Takeuchi R et al. | Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth. | 2016 | Br. J. Pharmacol. | pmid:26676684 |
| Jiang F and Dusting GJ | Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats. | 2001 | Br. J. Pharmacol. | pmid:11264250 |
| Doughty JM et al. | Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium. | 2001 | Br. J. Pharmacol. | pmid:11156589 |
| Wong PS et al. | Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? | 2014 | Br. J. Pharmacol. | pmid:24467384 |
| Guan BC et al. | Blockade of gap junction coupling by glycyrrhetinic acids in guinea pig cochlear artery: a whole-cell voltage- and current-clamp study. | 2007 | Br. J. Pharmacol. | pmid:17572704 |
| Lee J et al. | Gap junctions contribute to astrocytic resistance against zinc toxicity. | 2011 | Brain Res. Bull. | pmid:21884763 |
| Hong X et al. | Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin. | 2012 | Cancer Lett. | pmid:22115964 |
| Kizub IV et al. | Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization. | 2013 | Cardiovasc. Res. | pmid:23708740 |
| Suswillo RF et al. | Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. | 2017 | Cell Biochem. Funct. | pmid:28083967 |
| Kansui Y et al. | Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries. | 2008 | Cell Calcium | pmid:18191200 |
| Zhu Y et al. | Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. | 2016 | Cell Metab. | pmid:27626200 |
| Kim YJ et al. | Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells. | 2014 | Cell. Mol. Life Sci. | pmid:24623558 |
| Tabuchi M et al. | The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. | 2012 | Cell. Mol. Neurobiol. | pmid:22488528 |
| Sato T et al. | Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog. | 2009 | Cell. Mol. Neurobiol. | pmid:19145483 |
| Guillotin B et al. | Human primary endothelial cells stimulate human osteoprogenitor cell differentiation. | 2004 | Cell. Physiol. Biochem. | pmid:15319536 |
| Li XD et al. | Panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities. | 2010 | Cell. Physiol. Biochem. | pmid:21220939 |
| Yamanouchi K et al. | 18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. | 2007 | Cell. Physiol. Biochem. | pmid:17982260 |
| Sun W et al. | Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid. | 2011 | Chem Biol Drug Des | pmid:21244638 |
| Chadjichristos CE et al. | Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells. | 2008 | Circ. Res. | pmid:18239136 |
| He B et al. | Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions. | 2009 | Clin. Cancer Res. | pmid:19723651 |
| Princen F et al. | A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect. | 1999 | Clin. Cancer Res. | pmid:10589781 |
| Piao H et al. | Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. | 2011 | Clin. Exp. Nephrol. | pmid:21153751 |
| Nejime N et al. | Possible participation of chloride ion channels in ATP release from cancer cells in suspension. | 2009 | Clin. Exp. Pharmacol. Physiol. | pmid:18986334 |
| Goto K et al. | Critical role of gap junctions in endothelium-dependent hyperpolarization in rat mesenteric arteries. | 2002 | Clin. Exp. Pharmacol. Physiol. | pmid:12060103 |
| Yadav DK et al. | Design, synthesis and in vitro evaluation of 18β-glycyrrhetinic acid derivatives for anticancer activity against human breast cancer cell line MCF-7. | 2014 | Curr. Med. Chem. | pmid:24180274 |
| Bertuzzi F et al. | Mechanisms of coordination of Ca2+ signals in pancreatic islet cells. | 1999 | Diabetes | pmid:10512361 |
| Yu J et al. | Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. | 2016 | Endocrinology | pmid:27035651 |
| Verma V et al. | Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins. | 2009 | Eur. J. Cell Biol. | pmid:18951659 |
| Perez Velazquez JL et al. | Role of gap junctional coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress and hippocampal damage. | 2006 | Eur. J. Neurosci. | pmid:16420410 |
| Nomura R et al. | Bee venom phospholipase A2-induced phasic contractions in mouse rectum: independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis. | 2013 | Eur. J. Pharmacol. | pmid:24012929 |
18alpha-glycyrrhetinic acid
18alpha-glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. 18alpha-glycyrrhetinic acid is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.
Cross Reference
Introduction
To understand associated biological information of 18alpha-glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 18alpha-glycyrrhetinic acid?
18alpha-glycyrrhetinic acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 18alpha-glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with 18alpha-glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 18alpha-glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.