| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zheng C et al. | Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth. | 2018 | Eur J Med Chem | pmid:29407985 |
| Bousquet PA et al. | Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29196263 |
| Wegener H et al. | Human norovirus GII.4(MI001) P dimer binds fucosylated and sialylated carbohydrates. | 2017 | Glycobiology | pmid:28973640 |
| Komura N et al. | Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. | 2017 | Meth. Enzymol. | pmid:28935104 |
| Valdes-Zayas A et al. | Immunologic Response Elicited in Breast Cancer Patients Receiving a NeuGcGM3-based Vaccine as Adjuvant Therapy. | 2017 | J. Immunother. | pmid:28604556 |
| Park HJ et al. | Ganglioside GM3 induces cumulus cell apoptosis through inhibition of epidermal growth factor receptor-mediated PI3K/AKT signaling pathways during in vitro maturation of pig oocytes. | 2017 | Mol. Reprod. Dev. | pmid:28585705 |
| Dufresne M et al. | Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry. | 2017 | Anal Bioanal Chem | pmid:27873002 |
| Han YB et al. | Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases. | 2017 | J. Biol. Chem. | pmid:28179425 |
| Choi H et al. | Monosialyl Ganglioside GM3 Decreases Apolipoprotein B-100 Secretion in Liver Cells. | 2017 | J. Cell. Biochem. | pmid:28019668 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Trilck M et al. | Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. | 2017 | Brain Res. | pmid:27923633 |
| Go S et al. | Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation. | 2017 | J. Biol. Chem. | pmid:28275055 |
| Chan RB et al. | Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis. | 2017 | PLoS ONE | pmid:28212433 |
| Matsubara T et al. | Selective Intracellular Delivery of Ganglioside GM3-Binding Peptide through Caveolae/Raft-Mediated Endocytosis. | 2017 | Biomacromolecules | pmid:28051846 |
| Dam DH et al. | Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility. | 2017 | J. Invest. Dermatol. | pmid:27729281 |
| Delannoy CP et al. | Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages. | 2017 | J. Proteome Res. | pmid:27351377 |
| Hedger G et al. | Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor. | 2016 | J Phys Chem B | pmid:27109430 |
| Kawashima N et al. | Induction of Glycosphingolipid GM3 Expression by Valproic Acid Suppresses Cancer Cell Growth. | 2016 | J. Biol. Chem. | pmid:27539856 |
| Wentworth JM et al. | GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women. | 2016 | Int J Obes (Lond) | pmid:26499445 |
| Menichella DM et al. | Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice. | 2016 | Mol Pain | pmid:27590073 |
| Palomo AG et al. | Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it's potential therapeutic implications. | 2016 | Clin. Exp. Metastasis | pmid:27449755 |
| Fedoryszak-Kuśka N et al. | Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells. | 2016 | Acta Biochim. Pol. | pmid:27172362 |
| Yoshinaga A et al. | NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation. | 2016 | Eur. J. Pharmacol. | pmid:27105818 |
| Winner LK et al. | A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome. | 2016 | Hum. Gene Ther. | pmid:26975339 |
| Gentilini MV et al. | The tumor antigen N-glycolyl-GM3 is a human CD1d ligand capable of mediating B cell and natural killer T cell interaction. | 2016 | Cancer Immunol. Immunother. | pmid:26969612 |
| Gabri MR et al. | Racotumomab for treating lung cancer and pediatric refractory malignancies. | 2016 | Expert Opin Biol Ther | pmid:26903265 |
| Wang H et al. | Early growth and development impairments in patients with ganglioside GM3 synthase deficiency. | 2016 | Clin. Genet. | pmid:26649472 |
| King B et al. | Low-dose, continual enzyme delivery ameliorates some aspects of established brain disease in a mouse model of a childhood-onset neurodegenerative disorder. | 2016 | Exp. Neurol. | pmid:26626972 |
| Xu F et al. | Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. | 2016 | ACS Nano | pmid:26720275 |
| Shorthouse D et al. | Molecular simulations of glycolipids: Towards mammalian cell membrane models. | 2016 | Biochimie | pmid:26427555 |
| Murthy RV et al. | Exploiting the lactose-GM3 interaction for drug delivery. | 2015 | ChemMedChem | pmid:25801320 |
| Guan F et al. | Ganglioside-magnetosome complex formation enhances uptake of gangliosides by cells. | 2015 | Int J Nanomedicine | pmid:26609230 |
| Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
| Grey M et al. | Acceleration of α-synuclein aggregation by exosomes. | 2015 | J. Biol. Chem. | pmid:25425650 |
| Margheri F et al. | Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis. | 2015 | J. Cell. Mol. Med. | pmid:25313007 |
| Miklavcic JJ et al. | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease. | 2015 | World J. Gastroenterol. | pmid:26401073 |
| Lipina C and Hundal HS | Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms. | 2015 | FEBS Lett. | pmid:26434718 |
| Saariaho AH et al. | Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus. | 2015 | J. Autoimmun. | pmid:26227560 |
| Dorvignit D et al. | Antitumor and cytotoxic properties of a humanized antibody specific for the GM3(Neu5Gc) ganglioside. | 2015 | Immunobiology | pmid:26224247 |
| Rodriguez-Zhurbenko N et al. | Anti-NeuGcGM3 reactivity: a possible role of natural antibodies and B-1 cells in tumor immunosurveillance. | 2015 | Ann. N. Y. Acad. Sci. | pmid:26214505 |
| Piperno GM et al. | Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody. | 2015 | Gene Ther. | pmid:26181624 |
| Veillon L et al. | Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome. | 2015 | PLoS ONE | pmid:26102277 |
| Sugawara Y et al. | Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3. | 2015 | FEBS J. | pmid:26077172 |
| Dodge JC et al. | Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26056266 |
| Vukovic I et al. | The missing link - likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy. | 2015 | Kidney Blood Press. Res. | pmid:26043887 |
| Zheng XJ et al. | Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen. | 2015 | Org. Biomol. Chem. | pmid:25982227 |
| Mozzi A et al. | NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels. | 2015 | Glycobiology | pmid:25922362 |
| Randeria PS et al. | siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25902507 |
| Yu X et al. | Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse. | 2015 | ACS Nano | pmid:25853367 |
| DeMarco ML | Molecular dynamics simulations of membrane- and protein-bound glycolipids using GLYCAM. | 2015 | Methods Mol. Biol. | pmid:25753721 |
| Yoshikawa M et al. | Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells. | 2015 | Hum. Mol. Genet. | pmid:25652401 |
| Martinez-Martin N et al. | Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. | 2015 | Nat Commun | pmid:25625471 |
| Hakomori SI and Handa K | GM3 and cancer. | 2015 | Glycoconj. J. | pmid:25613425 |
| Li Y et al. | Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling. | 2015 | Mol Med Rep | pmid:25503644 |
| Hernández AM and Vázquez AM | Racotumomab-alum vaccine for the treatment of non-small-cell lung cancer. | 2015 | Expert Rev Vaccines | pmid:25420897 |
| Torbidoni AV et al. | Immunoreactivity of the 14F7 Mab raised against N-Glycolyl GM3 Ganglioside in retinoblastoma tumours. | 2015 | Acta Ophthalmol | pmid:25403557 |
| Nagafuku M et al. | Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3. | 2015 | Glycobiology | pmid:25303960 |
| Albohy A et al. | Mapping substrate interactions of the human membrane-associated neuraminidase, NEU3, using STD NMR. | 2015 | Glycobiology | pmid:25294388 |
| Kaneko T et al. | Histochemical and immunoelectron microscopic analysis of ganglioside GM3 in human kidney. | 2015 | Clin. Exp. Nephrol. | pmid:24985965 |
| Boccuto L et al. | A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. | 2014 | Hum. Mol. Genet. | pmid:24026681 |
| Kang S et al. | Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. | 2014 | Gene | pmid:24534465 |
| Li X et al. | Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. | 2014 | PLoS ONE | pmid:24475307 |
| Willing AE et al. | Repeated administrations of human umbilical cord blood cells improve disease outcomes in a mouse model of Sanfilippo syndrome type III B. | 2014 | Cell Transplant | pmid:25565636 |
| Sapra G et al. | The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. | 2014 | Nat Commun | pmid:25489988 |
| Yau YY et al. | Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases. | 2014 | Discov Med | pmid:25227752 |
| Giuffrida F et al. | Longitudinal evolution of the concentration of gangliosides GM3 and GD3 in human milk. | 2014 | Lipids | pmid:25186772 |
| Yu X et al. | Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells. | 2014 | Nat Commun | pmid:24947940 |
| Jin UH et al. | Ganglioside GM3 is required for caffeic acid phenethyl ester-induced megakaryocytic differentiation of human chronic myelogenous leukemia K562 cells. | 2014 | Biochem. Cell Biol. | pmid:24934090 |
| Gajdosik Z | Racotumomab - a novel anti-idiotype monoclonal antibody vaccine for the treatment of cancer. | 2014 | Drugs Today | pmid:24918647 |
| Jaishree G and Sharmila DJ | Molecular dynamics study of the conformations of glycosidic linkages in sialic acid modified ganglioside GM3 analogues. | 2014 | Glycoconj. J. | pmid:24909815 |
| Lukina E et al. | Eliglustat, an investigational oral therapy for Gaucher disease type 1: Phase 2 trial results after 4 years of treatment. | 2014 | Blood Cells Mol. Dis. | pmid:24835462 |
| Chung TW et al. | The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. | 2014 | PLoS ONE | pmid:24829158 |
| Alfonso S et al. | A randomized, multicenter, placebo-controlled clinical trial of racotumomab-alum vaccine as switch maintenance therapy in advanced non-small cell lung cancer patients. | 2014 | Clin. Cancer Res. | pmid:24788102 |
| Huang Q et al. | A new liquid chromatography/tandem mass spectrometry method for quantification of gangliosides in human plasma. | 2014 | Anal. Biochem. | pmid:24680754 |
| Lee H et al. | Inhibition of GM3 synthase attenuates neuropathology of Niemann-Pick disease Type C. by affecting sphingolipid metabolism. | 2014 | Mol. Cells | pmid:24599001 |
| Qu H et al. | Synthesis and cytotoxicity assay of four ganglioside GM3 analogues. | 2014 | Eur J Med Chem | pmid:24534540 |
| Inokuchi J | GM3 and diabetes. | 2014 | Glycoconj. J. | pmid:24399479 |
| Wang XQ et al. | Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors. | 2014 | J. Invest. Dermatol. | pmid:24326453 |
| Kim SJ et al. | Monosialic ganglioside GM3 specifically suppresses the monocyte adhesion to endothelial cells for inflammation. | 2014 | Int. J. Biochem. Cell Biol. | pmid:24120649 |
| Niimi K et al. | Improvement of spontaneous alternation behavior deficit by activation of α4β2 nicotinic acetylcholine receptor signaling in the ganglioside GM3-deficient mice. | 2013 | Biomed. Res. | pmid:23995055 |
| Hidari KI et al. | Influenza virus utilizes N-linked sialoglycans as receptors in A549 cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23747419 |
| Puryear WB et al. | Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. | 2013 | PLoS Pathog. | pmid:23593001 |
| Richichi B et al. | Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion. | 2013 | Bioorg. Med. Chem. | pmid:23583030 |
| Novak A et al. | Renal distribution of ganglioside GM3 in rat models of types 1 and 2 diabetes. | 2013 | J. Physiol. Biochem. | pmid:23564406 |
| Casadesús AV et al. | A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells. | 2013 | Glycoconj. J. | pmid:23547010 |
| Yan Q et al. | Deacetylated GM3 promotes uPAR-associated membrane molecular complex to activate p38 MAPK in metastatic melanoma. | 2013 | Mol. Cancer Res. | pmid:23525268 |
| Huang X et al. | Ganglioside GM3 inhibits hepatoma cell motility via down-regulating activity of EGFR and PI3K/AKT signaling pathway. | 2013 | J. Cell. Biochem. | pmid:23355442 |
| RodrÃguez-Zhurbenko N et al. | Human antibodies reactive to NeuGcGM3 ganglioside have cytotoxic antitumor properties. | 2013 | Eur. J. Immunol. | pmid:23319307 |
| Oda M et al. | Bacillus cereus sphingomyelinase recognizes ganglioside GM3. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23313504 |
| Inokuchi J et al. | Heterogeneity of gangliosides among T cell subsets. | 2013 | Cell. Mol. Life Sci. | pmid:23233133 |
| Scaringi R et al. | NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α. | 2013 | J. Biol. Chem. | pmid:23209287 |
| Rojas G et al. | Engineering the binding site of an antibody against N-glycolyl GM3: from functional mapping to novel anti-ganglioside specificities. | 2013 | ACS Chem. Biol. | pmid:23138862 |
| Wang H et al. | Antitumor effects of exogenous ganglioside GM3 on bladder cancer in an orthotopic cancer model. | 2013 | Urology | pmid:23102779 |
| Hayashi N et al. | Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody. | 2013 | Cancer Sci. | pmid:23004020 |
| Margheri G et al. | Fabrication of GM3-enriched sphingomyelin/cholesterol solid-supported lipid membranes on Au/SiO2 plasmonic substrates. | 2013 | Lipids | pmid:23591593 |
| Fantini J and Yahi N | The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains. | 2013 | Adv. Exp. Med. Biol. | pmid:23775688 |
| Nakashita M et al. | Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors. | 2013 | Dig. Dis. Sci. | pmid:22918683 |
| Li Y et al. | Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23968914 |
| Li Y et al. | Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling. | 2013 | Mol. Cell. Biochem. | pmid:23749170 |
| Brands M et al. | No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men. | 2013 | J. Clin. Endocrinol. Metab. | pmid:23386653 |
G(M3) Ganglioside
G(M3) Ganglioside is a lipid of Sphingolipids (SP) class. G(m3) ganglioside is associated with abnormalities such as Metabolic Diseases, Nodular glomerulosclerosis, Renal glomerular disease, Diabetes Mellitus and Hyperglycemia. The involved functions are known as Drug Interactions, Signal Transduction, Down-Regulation, Detergents and Ligand Binding. G(m3) ganglioside often locates in Tissue membrane, Body tissue, Cell surface, Membrane and Extracellular Matrix. The associated genes with G(M3) Ganglioside are PTPN11 gene, anti-IgM, Homologous Gene, SCAP2 gene and N-dodecyl-L-lysine amide. The related lipids are de-N-acetylneuraminyllactosylceramide, Membrane Lipids, Sphingolipids, stearic acid and sialogangliosides.
Cross Reference
Introduction
To understand associated biological information of G(M3) Ganglioside, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with G(M3) Ganglioside?
G(M3) Ganglioside is suspected in Renal glomerular disease, Sandhoff Disease, Nodular glomerulosclerosis, Diabetic Nephropathy, Diabetes, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with G(M3) Ganglioside
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with G(M3) Ganglioside?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with G(M3) Ganglioside?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with G(M3) Ganglioside?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with G(M3) Ganglioside?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with G(M3) Ganglioside?
There are no associated biomedical information in the current reference collection.