G(M3) Ganglioside

G(M3) Ganglioside is a lipid of Sphingolipids (SP) class. G(m3) ganglioside is associated with abnormalities such as Metabolic Diseases, Nodular glomerulosclerosis, Renal glomerular disease, Diabetes Mellitus and Hyperglycemia. The involved functions are known as Drug Interactions, Signal Transduction, Down-Regulation, Detergents and Ligand Binding. G(m3) ganglioside often locates in Tissue membrane, Body tissue, Cell surface, Membrane and Extracellular Matrix. The associated genes with G(M3) Ganglioside are PTPN11 gene, anti-IgM, Homologous Gene, SCAP2 gene and N-dodecyl-L-lysine amide. The related lipids are de-N-acetylneuraminyllactosylceramide, Membrane Lipids, Sphingolipids, stearic acid and sialogangliosides.

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Introduction

To understand associated biological information of G(M3) Ganglioside, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with G(M3) Ganglioside?

G(M3) Ganglioside is suspected in Renal glomerular disease, Sandhoff Disease, Nodular glomerulosclerosis, Diabetic Nephropathy, Diabetes, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with G(M3) Ganglioside

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with G(M3) Ganglioside?

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What functions are associated with G(M3) Ganglioside?


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What lipids are associated with G(M3) Ganglioside?

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What genes are associated with G(M3) Ganglioside?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with G(M3) Ganglioside?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with G(M3) Ganglioside

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Authors Title Published Journal PubMed Link
Zheng C et al. Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth. 2018 Eur J Med Chem pmid:29407985
Bousquet PA et al. Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute. 2018 Biochem. Biophys. Res. Commun. pmid:29196263
Wegener H et al. Human norovirus GII.4(MI001) P dimer binds fucosylated and sialylated carbohydrates. 2017 Glycobiology pmid:28973640
Komura N et al. Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. 2017 Meth. Enzymol. pmid:28935104
Valdes-Zayas A et al. Immunologic Response Elicited in Breast Cancer Patients Receiving a NeuGcGM3-based Vaccine as Adjuvant Therapy. 2017 J. Immunother. pmid:28604556
Park HJ et al. Ganglioside GM3 induces cumulus cell apoptosis through inhibition of epidermal growth factor receptor-mediated PI3K/AKT signaling pathways during in vitro maturation of pig oocytes. 2017 Mol. Reprod. Dev. pmid:28585705
Dufresne M et al. Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry. 2017 Anal Bioanal Chem pmid:27873002
Han YB et al. Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases. 2017 J. Biol. Chem. pmid:28179425
Choi H et al. Monosialyl Ganglioside GM3 Decreases Apolipoprotein B-100 Secretion in Liver Cells. 2017 J. Cell. Biochem. pmid:28019668
Suzuki KGN et al. Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. 2017 Biochim. Biophys. Acta pmid:28734966
Trilck M et al. Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. 2017 Brain Res. pmid:27923633
Go S et al. Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation. 2017 J. Biol. Chem. pmid:28275055
Chan RB et al. Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis. 2017 PLoS ONE pmid:28212433
Matsubara T et al. Selective Intracellular Delivery of Ganglioside GM3-Binding Peptide through Caveolae/Raft-Mediated Endocytosis. 2017 Biomacromolecules pmid:28051846
Dam DH et al. Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility. 2017 J. Invest. Dermatol. pmid:27729281
Delannoy CP et al. Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages. 2017 J. Proteome Res. pmid:27351377
Yoshinaga A et al. NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation. 2016 Eur. J. Pharmacol. pmid:27105818
Winner LK et al. A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome. 2016 Hum. Gene Ther. pmid:26975339
Gentilini MV et al. The tumor antigen N-glycolyl-GM3 is a human CD1d ligand capable of mediating B cell and natural killer T cell interaction. 2016 Cancer Immunol. Immunother. pmid:26969612
Gabri MR et al. Racotumomab for treating lung cancer and pediatric refractory malignancies. 2016 Expert Opin Biol Ther pmid:26903265