G(M3) Ganglioside

G(M3) Ganglioside is a lipid of Sphingolipids (SP) class. G(m3) ganglioside is associated with abnormalities such as Metabolic Diseases, Nodular glomerulosclerosis, Renal glomerular disease, Diabetes Mellitus and Hyperglycemia. The involved functions are known as Drug Interactions, Signal Transduction, Down-Regulation, Detergents and Ligand Binding. G(m3) ganglioside often locates in Tissue membrane, Body tissue, Cell surface, Membrane and Extracellular Matrix. The associated genes with G(M3) Ganglioside are PTPN11 gene, anti-IgM, Homologous Gene, SCAP2 gene and N-dodecyl-L-lysine amide. The related lipids are de-N-acetylneuraminyllactosylceramide, Membrane Lipids, Sphingolipids, stearic acid and sialogangliosides.

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Introduction

To understand associated biological information of G(M3) Ganglioside, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with G(M3) Ganglioside?

G(M3) Ganglioside is suspected in Renal glomerular disease, Sandhoff Disease, Nodular glomerulosclerosis, Diabetic Nephropathy, Diabetes, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with G(M3) Ganglioside

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with G(M3) Ganglioside?

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What functions are associated with G(M3) Ganglioside?


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What lipids are associated with G(M3) Ganglioside?

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What genes are associated with G(M3) Ganglioside?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with G(M3) Ganglioside?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with G(M3) Ganglioside

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Authors Title Published Journal PubMed Link
Tsukuda Y et al. Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. 2012 PLoS ONE pmid:22768242
Rusciani A et al. Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation. 2010 PLoS ONE pmid:21103358
Caughlin S et al. Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. 2015 PLoS ONE pmid:26086081
Yahi N et al. How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40). 2010 PLoS ONE pmid:20140095
Li X et al. Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. 2014 PLoS ONE pmid:24475307
Chan RB et al. Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis. 2017 PLoS ONE pmid:28212433
Veillon L et al. Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome. 2015 PLoS ONE pmid:26102277
Garbuzova-Davis S et al. Blood-brain barrier impairment in an animal model of MPS III B. 2011 PLoS ONE pmid:21408219
Paccalet T et al. Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease. 2010 PLoS ONE pmid:20383336
Chung TW et al. The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. 2014 PLoS ONE pmid:24829158
Mitchell MD et al. Transfer of gangliosides across the human placenta. 2012 Placenta pmid:22225907
Nakano J et al. Lack of the induction of anti-ganglioside GM3 antibody in the patients with malignant melanoma in Japanese. 1998 Pigment Cell Res. pmid:9711536
Scursoni AM et al. Detection and characterization of N-glycolyated gangliosides in Wilms tumor by immunohistochemistry. Pediatr. Dev. Pathol. pmid:19435393
Sorice M et al. Evidence for the existence of ganglioside molecules in the antigen of Entamoeba histolytica. 1996 Parasite Immunol. pmid:9223167
Seah N et al. Probing the lactose.GM3 carbohydrate-carbohydrate interaction with glycodendrimers. 2009 Org. Lett. pmid:19123846
Jacques S et al. Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications. 2006 Org. Biomol. Chem. pmid:16358009
Zheng XJ et al. Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen. 2015 Org. Biomol. Chem. pmid:25982227
Zhong Y et al. N-Glycolyl GM3 ganglioside immunoexpression in oral mucosal melanomas of Chinese. 2012 Oral Dis pmid:22574836
Wang P et al. GM3 signals regulating TNF-alpha expression are mediated by Rictor and Arhgdib in mouse melanoma B16 cells. 2007 Oncology pmid:18523362
Bitton RJ et al. Cancer vaccines: an update with special focus on ganglioside antigens. Oncol. Rep. pmid:11836591