G(M3) Ganglioside

G(M3) Ganglioside is a lipid of Sphingolipids (SP) class. G(m3) ganglioside is associated with abnormalities such as Metabolic Diseases, Nodular glomerulosclerosis, Renal glomerular disease, Diabetes Mellitus and Hyperglycemia. The involved functions are known as Drug Interactions, Signal Transduction, Down-Regulation, Detergents and Ligand Binding. G(m3) ganglioside often locates in Tissue membrane, Body tissue, Cell surface, Membrane and Extracellular Matrix. The associated genes with G(M3) Ganglioside are PTPN11 gene, anti-IgM, Homologous Gene, SCAP2 gene and N-dodecyl-L-lysine amide. The related lipids are de-N-acetylneuraminyllactosylceramide, Membrane Lipids, Sphingolipids, stearic acid and sialogangliosides.

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Introduction

To understand associated biological information of G(M3) Ganglioside, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with G(M3) Ganglioside?

G(M3) Ganglioside is suspected in Renal glomerular disease, Sandhoff Disease, Nodular glomerulosclerosis, Diabetic Nephropathy, Diabetes, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with G(M3) Ganglioside

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with G(M3) Ganglioside?

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What functions are associated with G(M3) Ganglioside?


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What lipids are associated with G(M3) Ganglioside?

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What genes are associated with G(M3) Ganglioside?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with G(M3) Ganglioside?

There are no associated biomedical information in the current reference collection.

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All references with G(M3) Ganglioside

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Authors Title Published Journal PubMed Link
Tsukuda Y et al. Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. 2012 PLoS ONE pmid:22768242
Rusciani A et al. Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation. 2010 PLoS ONE pmid:21103358
Chan RB et al. Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis. 2017 PLoS ONE pmid:28212433
Puryear WB et al. Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. 2013 PLoS Pathog. pmid:23593001
Inokuchi J Physiopathological function of hematoside (GM3 ganglioside). 2011 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:21558756
Nojiri H et al. Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3456169
Yoon SJ et al. Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17142315
Pierini LM and Maxfield FR Flotillas of lipid rafts fore and aft. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11504934
Todeschini AR et al. Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18272501
Pohlentz G et al. Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3140234