Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GM2?

Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GM2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GM2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ganglioside GM2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GM2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ganglioside GM2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GM2?

Disease model

Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ganglioside GM2

Download all related citations
Per page 10 20 50 100 | Total 558
Authors Title Published Journal PubMed Link
pmid:
Mundel TM et al. Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells. 1999 J. Am. Soc. Nephrol. pmid:10073593
Khalili-Shirazi A et al. Antiganglioside antibodies in Guillain-Barré syndrome after a recent cytomegalovirus infection. 1999 J. Neurol. Neurosurg. Psychiatry pmid:10084538
Li YT et al. Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation. 1999 J. Biol. Chem. pmid:10187778
Mizutani K et al. Enhancement of TNF-alpha production by ganglioside GM2 in human mononuclear cell culture. 1999 Neuroreport pmid:10208534
Raghavan S et al. G(M2)-ganglioside metabolism in situ in mucolipidosis IV fibroblasts. 1999 Neurochem. Res. pmid:10227679
Kemp SF and Stoolmiller AC Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells. Precursor-product relationships among sialoglycosphingolipids. 1976 J. Biol. Chem. pmid:1033935
Cavanna B et al. Anti-GM2 IgM antibodies: clinical correlates and reactivity with a human neuroblastoma cell line. 1999 J. Neuroimmunol. pmid:10376949
Ecsedy JA et al. Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice. 1999 J. Neurochem. pmid:10386978
Slevin M et al. Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. 1999 Int. J. Cancer pmid:10399959