| Authors | Title | Published | Journal | PubMed Link |
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| pmid:11495348 | ||||
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| pmid:8120069 | ||||
| pmid:19559406 | ||||
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| Woods AS et al. | Gangliosides and ceramides change in a mouse model of blast induced traumatic brain injury. | 2013 | ACS Chem Neurosci | pmid:23590251 |
| Ho CW et al. | Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. | 2010 | ACS Chem. Biol. | pmid:20187655 |
| Obi T et al. | IgM M-protein in a patient with sensory-dominant neuropathy binds preferentially to polysialogangliosides. | 1992 | Acta Neurol. Scand. | pmid:1384262 |
| Sindern E et al. | Serum antibodies to GM1 and GM3-gangliosides in systemic lupus erythematosus with chronic inflammatory demyelinating polyradiculoneuropathy. | 1991 | Acta Neurol. Scand. | pmid:1887763 |
| Martin DR et al. | Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis. | 2005 | Acta Neuropathol. | pmid:16200419 |
| Gieselmann V | What can cell biology tell us about heterogeneity in lysosomal storage diseases? | 2005 | Acta Paediatr Suppl | pmid:15895717 |
| Kroll RA et al. | White matter changes associated with feline GM2 gangliosidosis (Sandhoff disease): correlation of MR findings with pathologic and ultrastructural abnormalities. | AJNR Am J Neuroradiol | pmid:7677013 | |
| Raghavan SS et al. | GM2-ganglioside metabolism in hexosaminidase A deficiency states: determination in situ using labeled GM2 added to fibroblast cultures. | 1985 | Am. J. Hum. Genet. | pmid:2934978 |
| Navon R et al. | Hereditary heat-labile hexosaminidase B: a variant whose homozygotes synthesize a functional HEX A. | 1985 | Am. J. Hum. Genet. | pmid:3156493 |
| Conzelmann E et al. | Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level. | 1983 | Am. J. Hum. Genet. | pmid:6614006 |
| Inui K et al. | Juvenile GM2 gangliosidosis (AMB variant): inability to activate hexosaminidase A by activator protein. | 1983 | Am. J. Hum. Genet. | pmid:6224417 |
| Li YT et al. | Differentiation of two variants of type-AB GM2-gangliosidosis using chromogenic substrates. | 1983 | Am. J. Hum. Genet. | pmid:6222647 |
| Johnson WG et al. | Alpha-locus hexosaminidase genetic compound with juvenile gangliosidosis phenotype: clinical, genetic, and biochemical studies. | 1980 | Am. J. Hum. Genet. | pmid:6772023 |
| O'Brien JS and Geiger B | Normal adult with absent HEX A: immunoreactive HEX A is present. | 1979 | Am. J. Hum. Genet. | pmid:507054 |
| O'Brien JS et al. | Characterization of unusual hexosaminidase A (HEX A) deficient human mutants. | 1978 | Am. J. Hum. Genet. | pmid:747188 |
| Xie B et al. | A Cys138-to-Arg substitution in the GM2 activator protein is associated with the AB variant form of GM2 gangliosidosis. | 1992 | Am. J. Hum. Genet. | pmid:1570834 |
| dos Santos MR et al. | GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene mutations in 11 patients from a defined region in Portugal. | 1991 | Am. J. Hum. Genet. | pmid:1832817 |
| Navon R et al. | Ashkenazi-Jewish and non-Jewish adult GM2 gangliosidosis patients share a common genetic defect. | 1990 | Am. J. Hum. Genet. | pmid:2278539 |
| Pierce KR et al. | Animal model of human disease: GM2 gangliosidosis. | 1976 | Am. J. Pathol. | pmid:817606 |
| Gori AH et al. | Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. | 1999 | Am. J. Trop. Med. Hyg. | pmid:10497993 |
| Dufresne M et al. | Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry. | 2017 | Anal Bioanal Chem | pmid:27873002 |
| Schwarz A et al. | Isolation of gangliosides by cloud-point extraction with a nonionic detergent. | 1997 | Anal. Biochem. | pmid:9417780 |
| Fuller M et al. | Liquid chromatography/electrospray ionisation-tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma. | 2014 | Anal. Biochem. | pmid:24769373 |
| Nakamura M et al. | Radioimmune assay of sialyltransferase and N-acetylgalactosaminyltransferase activities using specific antibodies on a 96-well filtration plate of a multiscreen assay system. | 1991 | Anal. Biochem. | pmid:1789418 |
| Kushi Y et al. | Direct analysis of glycolipids on thin-layer plates by matrix-assisted secondary ion mass spectrometry: application for glycolipid storage disorders. | 1988 | Anal. Biochem. | pmid:3149874 |
| Kim CS et al. | Functional interaction analysis of GM1-related carbohydrates and Vibrio cholerae toxins using carbohydrate microarray. | 2012 | Anal. Chem. | pmid:22770420 |
| Chen Y et al. | Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. | 2008 | Anal. Chem. | pmid:18314967 |
| Boardman AK et al. | Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry. | 2008 | Anal. Chem. | pmid:18717573 |
| Sato K et al. | Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23765733 |
| Stubbs KA et al. | A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19130519 |
| Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
| Burg J et al. | Mapping of the gene coding for the human GM2 activator protein to chromosome 5. | 1985 | Ann. Hum. Genet. | pmid:3865618 |
| Swallow DM et al. | Regional localization of the gene coding for the GM2 activator protein (GM2A) to chromosome 5q32-33 and confirmation of the assignment of GM2AP to chromosome 3. | 1993 | Ann. Hum. Genet. | pmid:8257088 |
| Tifft CJ and Proia RL | The beta-hexosaminidase deficiency disorders: development of a clinical paradigm in the mouse. | 1997 | Ann. Med. | pmid:9562524 |
| Nakamura K et al. | Anti-GM2 antibodies in Guillain-Barré syndrome with acute cytomegalovirus infection. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668386 |
| Walkley SU et al. | GM2 ganglioside as a regulator of pyramidal neuron dendritogenesis. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668352 |
| Kotagal S | Diagnosis of AB variant, GM2 gangliosidosis. | 1986 | Ann. Neurol. | pmid:3080943 |
| Santafé MM et al. | Changes in the neuromuscular synapse induced by an antibody against gangliosides. | 2005 | Ann. Neurol. | pmid:15732093 |
| Meek D et al. | Juvenile progressive dystonia: a new phenotype of GM2 gangliosidosis. | 1984 | Ann. Neurol. | pmid:6430210 |
| Navon R et al. | Juvenile-onset spinal muscular atrophy caused by compound heterozygosity for mutations in the HEXA gene. | 1997 | Ann. Neurol. | pmid:9153525 |
| Renshaw PF et al. | Electroconvulsive therapy treatment of depression in a patient with adult GM2 gangliosidosis. | 1992 | Ann. Neurol. | pmid:1386210 |
| Saito M and Sugiyama K | Gangliosides in rat kidney: composition, distribution, and developmental changes. | 2001 | Arch. Biochem. Biophys. | pmid:11360994 |
| Ruan S et al. | Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression. | 1995 | Arch. Biochem. Biophys. | pmid:7487055 |
| Jolivet-Reynaud C et al. | Damaging effects of Clostridium perfringens delta toxin on blood platelets and their relevance to ganglioside GM2. | 1988 | Arch. Biochem. Biophys. | pmid:3162668 |
| Torres BV et al. | Glycolipid-lectin interactions: reactivity of lectins from Helix pomatia, Wisteria floribunda, and Dolichos biflorus with glycolipids containing N-acetylgalactosamine. | 1988 | Arch. Biochem. Biophys. | pmid:3355161 |
| Duan J et al. | Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor'. | 2006 | Arch. Biochem. Biophys. | pmid:16962990 |
| Hadfield MG et al. | Pathologic findings in mucopolysaccharidosis type IIIB (Sanfilippo's sydnrome B). | 1980 | Arch. Neurol. | pmid:6775621 |
| Rapin I et al. | Adult (chronic) GM2 gangliosidosis. Atypical spinocerebellar degeneration in a Jewish sibship. | 1976 | Arch. Neurol. | pmid:175770 |
| Rockwell HE et al. | AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. | ASN Neuro | pmid:25873306 | |
| Kirvan CA et al. | Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea. | 2006 | Autoimmunity | pmid:16455579 |
| Kasai N et al. | Preparation and specificity of avian anti-GM2(NeuGc) ganglioside antiserum. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3925943 |
| Li YT et al. | Occurrence of ceramide-glycanase in the earthworm, Lumbricus terrestris. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3689409 |
| Li SC et al. | A new variant of type-AB GM2-gangliosidosis. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306091 |
| Nakamura M et al. | Biosynthesis of the so-called "a" and "asialo" pathway glycosphingolipids is differentially regulated in murine myelogenous leukemia NFS60 cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:8554592 |
| Kuroki Y et al. | A novel missense mutation (C522Y) is present in the beta-hexosaminidase beta-subunit gene of a Japanese patient with infantile Sandhoff disease. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626071 |
| Beccari T et al. | GM2 activator protein expression in mouse tissues. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7980537 |
| Tomioka R et al. | Neuroblastoma GOTO cells are hypersensitive to disruption of lipid rafts. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19706290 |
| Xie B et al. | Isolation and expression of a full-length cDNA encoding the human GM2 activator protein. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2059210 |
| Tanabe A et al. | Obesity causes a shift in metabolic flow of gangliosides in adipose tissues. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19116132 |
| Kondo Y et al. | Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. | 2009 | Biochem. Biophys. Res. Commun. | pmid:18996356 |
| Tanaka A et al. | GM2-gangliosidosis B1 variant: a wide geographic and ethnic distribution of the specific beta-hexosaminidase alpha chain mutation originally identified in a Puerto Rican patient. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2973311 |
| Hechtman P and Kachra Z | Interaction of activating protein and surfactants with human liver hexosaminidase A and GM2 ganglioside. | 1980 | Biochem. J. | pmid:7387624 |
| Hechtman P and LeBlanc D | Purification and properties of the hexosaminidase A-activating protein from human liver. | 1977 | Biochem. J. | pmid:603630 |
| Masson E et al. | Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides. | 2005 | Biochem. J. | pmid:15654767 |
| Haraguchi M et al. | The effects of the site-directed removal of N-glycosylation sites from beta-1,4-N-acetylgalactosaminyltransferase on its function. | 1995 | Biochem. J. | pmid:7492324 |
| Li SC et al. | Degradation of G(M1) and G(M2) by mammalian sialidases. | 2001 | Biochem. J. | pmid:11696012 |
| Hidari JK et al. | beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F. | 1994 | Biochem. J. | pmid:7980468 |
| Bellachioma G et al. | Cloning and sequence analysis of a cDNA clone coding for the mouse GM2 activator protein. | 1993 | Biochem. J. | pmid:7689829 |
| Klima H et al. | Over-expression of a functionally active human GM2-activator protein in Escherichia coli. | 1993 | Biochem. J. | pmid:8503891 |
| Trinchera M et al. | The N-acetylgalactosamine residue of exogenous GM2 ganglioside is recycled for glycoconjugate biosynthesis in rat liver. | 1990 | Biochem. J. | pmid:2310367 |
| DeGasperi R et al. | Isolation and characterization of an activator protein for the hydrolysis of ganglioside GM2 from the roe of striped mullet (Mugil cephalus). | 1989 | Biochem. J. | pmid:2527497 |
| Kolter T et al. | Recent advances in the biochemistry of glycosphingolipid metabolism. | 1999 | Biochem. Soc. Trans. | pmid:10917612 |
| Xie B et al. | Biochemical characterization of the Cys138Arg substitution associated with the AB variant form of GM2 gangliosidosis: evidence that Cys138 is required for the recognition of the GM2 activator/GM2 ganglioside complex by beta-hexosaminidase A. | 1998 | Biochemistry | pmid:9454570 |
| Rigat B et al. | Two mechanisms for the recapture of extracellular GM2 activator protein: evidence for a major secretory form of the protein. | 1997 | Biochemistry | pmid:9204879 |
| Tse R et al. | Identification of functional domains within the alpha and beta subunits of beta-hexosaminidase A through the expression of alpha-beta fusion proteins. | 1996 | Biochemistry | pmid:8718882 |
| Tse R et al. | Identification of an active acidic residue in the catalytic site of beta-hexosaminidase. | 1996 | Biochemistry | pmid:8652542 |
| Hou Y et al. | Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A. | 1996 | Biochemistry | pmid:8672428 |
| Martinez Z et al. | GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. | 2007 | Biochemistry | pmid:17253773 |
| Raghavan S et al. | GM2-ganglioside metabolism in cultured human skin fibroblasts: unambiguous diagnosis of GM2-gangliosidosis. | 1985 | Biochim. Biophys. Acta | pmid:3995063 |
| Hoffman LM et al. | Human fetal brain cells in culture. Increase in GM2 ganglioside after SV-40 transformation. | 1981 | Biochim. Biophys. Acta | pmid:6271225 |
| Suzuki Y et al. | Action of ortho- and paramyxovirus neuraminidase on gangliosides. Hydrolysis of ganglioside GM1 by Sendai virus neuraminidase. | 1980 | Biochim. Biophys. Acta | pmid:6257300 |
| Mahuran DJ | Biochemical consequences of mutations causing the GM2 gangliosidoses. | 1999 | Biochim. Biophys. Acta | pmid:10571007 |
| Mahuran DJ | The GM2 activator protein, its roles as a co-factor in GM2 hydrolysis and as a general glycolipid transport protein. | 1998 | Biochim. Biophys. Acta | pmid:9714704 |
| Sato T et al. | Quantitative measurements of the interaction between monosialoganglioside monolayers and wheat germ agglutinin (WGA) by a quartz-crystal microbalance. | 1998 | Biochim. Biophys. Acta | pmid:9545544 |
| Rosales Fritz VM et al. | Chinese hamster ovary cells lacking GM1 and GD1a synthesize gangliosides upon transfection with human GM2 synthase. | 1997 | Biochim. Biophys. Acta | pmid:9396632 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Sanai Y et al. | Monoclonal antibody directed to a Hanganutziu-Deicher active ganglioside, GM2 (NeuGc). | 1988 | Biochim. Biophys. Acta | pmid:2449247 |
| Taga S et al. | Sequential changes in glycolipid expression during human B cell differentiation: enzymatic bases. | 1995 | Biochim. Biophys. Acta | pmid:7811747 |
| Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
| Hoffman LM et al. | SV-40 transformation: effect on GM2 ganglioside in cultured cell lines. | 1991 | Biochim. Biophys. Acta | pmid:1647206 |
| Mahuran DJ | The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis. | 1991 | Biochim. Biophys. Acta | pmid:1825792 |
| Karlsson G et al. | Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2. | 1990 | Biochim. Biophys. Acta | pmid:1691018 |
| Yamanaka T et al. | Detection of gangliotriaose-series glycosphingolipids in serum of cord blood and patients with neuroblastoma by a sensitive TLC/enzyme-immunostaining method. | 1987 | Biochim. Biophys. Acta | pmid:3300782 |
| Yanagisawa K et al. | Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver. | 1987 | Biochim. Biophys. Acta | pmid:3109491 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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