| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:14766311 | ||||
| Schwerer B et al. | Antisera against ganglioside GM2: immunochemical and immunohistological studies. | Neuropathol. Appl. Neurobiol. | pmid:6214725 | |
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| Mikami M et al. | Characteristic alteration in the concentration of IV 3NeuAc alpha-nLc4Cer in the villi of human placenta during the gestational period. | Placenta | pmid:8248034 | |
| pmid:11495348 | ||||
| Boggs JM et al. | Immune lysis of lipid vesicles containing myelin basic protein or glycolipid antigens by multiple sclerosis and normal sera. | J. Neurol. Sci. | pmid:6085112 | |
| Rockwell HE et al. | AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. | ASN Neuro | pmid:25873306 | |
| McIntyre C et al. | Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery. | J Gene Med | pmid:25418946 | |
| Kroll RA et al. | White matter changes associated with feline GM2 gangliosidosis (Sandhoff disease): correlation of MR findings with pathologic and ultrastructural abnormalities. | AJNR Am J Neuroradiol | pmid:7677013 | |
| pmid: | ||||
| Dotta F et al. | Autoantigens in type 1 diabetes mellitus. | J. Endocrinol. Invest. | pmid:7829824 | |
| pmid:8120069 | ||||
| pmid:19559406 | ||||
| Arai M and Kusunoki S | [A case of multifocal motor neuropathy with IgM lambda anti-GM1 antibody and IgM kappa paraprotein reacting exclusively with GM2]. | Rinsho Shinkeigaku | pmid:19348179 | |
| Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
| pmid:18473163 | ||||
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| Volk BW et al. | The gangliosidoses. | 1975 | Hum. Pathol. | pmid:170187 |
| Op Den Velde W and Hooghwinkel GJ | The brain ganglioside pattern in presenile and senile dementia. | 1975 | J Am Geriatr Soc | pmid:1141629 |
| Holmgren J et al. | Interaction of cholera toxin and membrane GM1 ganglioside of small intestine. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1058471 |
| Molzer B and Bernheimer H | Detection of GM2-gangliosidosis (Tay-Sachs and Sandhoff disease) gene carriers by serum hexosaminidase assay. | 1976 | Clin. Chim. Acta | pmid:826357 |
| Purpura DP and Suzuki K | Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease. | 1976 | Brain Res. | pmid:824017 |
| Kemp SF and Stoolmiller AC | Studies on the biosynthesis of glyco-sphingolipids in cultured mouse neuroblastoma cells: characterization and acceptor specificities of N-acetylneuraminyl- and N-acetylgalactosaminyltransferases. | 1976 | J. Neurochem. | pmid:823300 |
| Hoffman LM et al. | GM2 ganglioside in fetal Tay-Sachs disease brain cultures: a model system for the disease. | 1976 | Brain Res. | pmid:953690 |
| Itaya K and Hakomori S | Gangliosides and 'galactoprotein A' ('LETS'-protein) of temperature-sensitive mutant of transformed 3T3 cells. | 1976 | FEBS Lett. | pmid:179896 |
| Pierce KR et al. | Animal model of human disease: GM2 gangliosidosis. | 1976 | Am. J. Pathol. | pmid:817606 |
| Rapin I et al. | Adult (chronic) GM2 gangliosidosis. Atypical spinocerebellar degeneration in a Jewish sibship. | 1976 | Arch. Neurol. | pmid:175770 |
| Kemp SF and Stoolmiller AC | Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells. Precursor-product relationships among sialoglycosphingolipids. | 1976 | J. Biol. Chem. | pmid:1033935 |
| Hechtman P and LeBlanc D | Purification and properties of the hexosaminidase A-activating protein from human liver. | 1977 | Biochem. J. | pmid:603630 |
| Hoffman LM et al. | Glycosphingolipids in fetal Tay-Sachs disease brain and lung cultures. | 1977 | J. Neurochem. | pmid:894310 |
| Bernheimer H et al. | Sandhoff disease: ganglioside G(M2) and asialo-G(M2) accumulation in the cerebrospinal fluid. | 1977 | J. Neurochem. | pmid:407331 |
| Duffard RO et al. | Ganglioside composition and biosynthesis in cultred cells derived from CNS. | 1977 | J. Neurochem. | pmid:406360 |
| Cork LC et al. | GM2 ganglioside lysosomal storage disease in cats with beta-hexosaminidase deficiency. | 1977 | Science | pmid:404709 |
| Ciesielski-Treska J et al. | Gangliosides of active and inactive neuroblastoma clones. | 1977 | Differentiation | pmid:202531 |
| O'Brien JS et al. | Ganglioside GM2 N-acetyl-beta-D-galactosaminidase and asialo GM2 (GA2) N-acetyl-beta-D-galactosaminidase; studies in human skin fibroblasts. | 1977 | Clin. Genet. | pmid:13950 |
| Geiger B and Smolarsky M | Immunochemical determination of ganglioside GM2, by inhibition of complement-dependent liposome lysis. | 1977 | J. Immunol. Methods | pmid:333030 |
| O'Brien JS et al. | Characterization of unusual hexosaminidase A (HEX A) deficient human mutants. | 1978 | Am. J. Hum. Genet. | pmid:747188 |
| O'Neill B et al. | Adult-onset GM2 gangliosidosis. Seizures, dementia, and normal pressure hydrocephalus associated with glycolipid storage in the brain and arachnoid granulation. | 1978 | Neurology | pmid:568730 |
| Kosanke SD et al. | Clinical and biochemical abnormalities in porcine GM2-gangliosidosis. | 1978 | Vet. Pathol. | pmid:108843 |
| Conzelmann E and Sandhoff K | AB variant of infantile GM2 gangliosidosis: deficiency of a factor necessary for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2. | 1978 | Proc. Natl. Acad. Sci. U.S.A. | pmid:99746 |
| Young WW et al. | Production of monoclonal antibodies specific for two distinct steric portions of the glycolipid ganglio-N-triosylceramide (asialo GM2). | 1979 | J. Exp. Med. | pmid:512581 |
| O'Brien JS and Geiger B | Normal adult with absent HEX A: immunoreactive HEX A is present. | 1979 | Am. J. Hum. Genet. | pmid:507054 |
| Novak A et al. | Preparation of radiolabeled GM2 and GA2 gangliosides. | 1979 | J. Lipid Res. | pmid:490046 |
| Li SC et al. | Evidence for the presence of two separate protein activators for the enzymic hydrolysis of GM1 and GM2 gangliosides. | 1979 | J. Biol. Chem. | pmid:115863 |
| Hadfield MG et al. | Pathologic findings in mucopolysaccharidosis type IIIB (Sanfilippo's sydnrome B). | 1980 | Arch. Neurol. | pmid:6775621 |
| Suzuki Y et al. | Action of ortho- and paramyxovirus neuraminidase on gangliosides. Hydrolysis of ganglioside GM1 by Sendai virus neuraminidase. | 1980 | Biochim. Biophys. Acta | pmid:6257300 |
| Johnson WG et al. | Alpha-locus hexosaminidase genetic compound with juvenile gangliosidosis phenotype: clinical, genetic, and biochemical studies. | 1980 | Am. J. Hum. Genet. | pmid:6772023 |
| Hechtman P and Kachra Z | Interaction of activating protein and surfactants with human liver hexosaminidase A and GM2 ganglioside. | 1980 | Biochem. J. | pmid:7387624 |
| Hoffman LM et al. | Tay-Sachs disease brain cells in culture: mobilization of stored GM2 after concanavalin A-mediated uptake of hexosaminidase A. | 1980 | J. Neurosci. Res. | pmid:7441795 |
| Holmgren J et al. | Polystyrene-adsorbed gangliosides for investigation of the structure of the tetanus-toxin receptor. | 1980 | Eur. J. Biochem. | pmid:7398619 |
| Erzberger A et al. | Assay of ganglioside GM2-N-acetyl-beta-D-galactosaminidase activity in human fibroblasts employing the natural activator protein--diagnosis of variant forms of GM2 gangliosidosis. | 1980 | Clin. Chim. Acta | pmid:6781795 |
| Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
| Hoffman LM et al. | Human fetal brain cells in culture. Increase in GM2 ganglioside after SV-40 transformation. | 1981 | Biochim. Biophys. Acta | pmid:6271225 |
| Li SC et al. | A new variant of type-AB GM2-gangliosidosis. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306091 |
| Pullarkat RK et al. | Accumulation of ganglioside Gm2 in cerebrospinal fluid of a patient with the variant AB of infantile Gm2 gangliosidosis. | 1981 | Pediatrics | pmid:7243492 |
| Li SC et al. | A protein activator for the enzymic hydrolysis of GM2 ganglioside. | 1981 | J. Biol. Chem. | pmid:7240201 |
| Watanabe T et al. | Human melanoma antigen AH is an autoantigenic ganglioside related to GD2. | 1982 | J. Exp. Med. | pmid:7175442 |
| Hasilik A et al. | Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6214395 |
| Poulos A et al. | Diagnosis of Tay-Sachs disease using [3H]N-acetylneuraminic acid labelled GM2 ganglioside as substrate. | 1982 | Clin. Chim. Acta | pmid:6210469 |
| Conzelmann E et al. | Complexing of glycolipids and their transfer between membranes by the activator protein for degradation of lysosomal ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6210531 |
| Hashimoto Y et al. | The occurrence of GM4 and GM2 in erythrocytes from inbred strains of mice. | 1982 | J. Biochem. | pmid:7076644 |
| Riedl M et al. | A ganglioside-dependent cellular binding mechanism in rat macrophages. | 1982 | J. Immunol. | pmid:7073871 |
| Yu RK et al. | Characterization of some minor gangliosides in Tay-Sachs brains. | 1983 | Brain Res. | pmid:6414648 |
| Kniep B et al. | Gangliotriaosylceramide (asialo GM2), a glycosphingolipid marker for cell lines derived from patients with Hodgkin's disease. | 1983 | J. Immunol. | pmid:6886427 |
| Conzelmann E et al. | Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level. | 1983 | Am. J. Hum. Genet. | pmid:6614006 |
| Tai T et al. | Ganglioside GM2 as a human tumor antigen (OFA-I-1). | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6193515 |
| Yusuf HK et al. | Ganglioside biosynthesis in Golgi apparatus of rat liver. Stimulation by phosphatidylglycerol and inhibition by tunicamycin. | 1983 | Eur. J. Biochem. | pmid:6861762 |
| Inui K et al. | Juvenile GM2 gangliosidosis (AMB variant): inability to activate hexosaminidase A by activator protein. | 1983 | Am. J. Hum. Genet. | pmid:6224417 |
| Li YT et al. | Differentiation of two variants of type-AB GM2-gangliosidosis using chromogenic substrates. | 1983 | Am. J. Hum. Genet. | pmid:6222647 |
| Hashimoto Y et al. | Genetic regulation of GM2 expression in liver of mouse. | 1983 | J. Biochem. | pmid:6874670 |
| Kaplan F and Hechtman P | Purification and properties of two enzymes catalyzing galactose transfer to GM2 ganglioside from rat liver Golgi. | 1983 | J. Biol. Chem. | pmid:6401719 |
| Hirabayashi Y et al. | The protein activator specific for the enzymic hydrolysis of GM2 ganglioside in normal human brain and brains of three types of GM2 gangliosidosis. | 1983 | J. Neurochem. | pmid:6848657 |
| Young WW et al. | Decreased glycolipid antigen expression in lymphoma cell variants escaping from anti-glycolipid serotherapy. | 1983 | J. Exp. Med. | pmid:6848617 |
| Harzer K | Assay of the GM2-ganglioside cleaving hexosaminidase activity of skin fibroblasts for GM2-gangliosidoses. | 1983 | Clin. Chim. Acta | pmid:6228344 |
| Seyfried TN et al. | Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. | 1984 | J. Neurochem. | pmid:6470710 |
| Sandhoff K and Conzelmann E | The biochemical basis of gangliosidoses. | 1984 | Neuropediatrics | pmid:6242704 |
| Goebel HH | Morphology of the gangliosidoses. | 1984 | Neuropediatrics | pmid:6100800 |
| Di Gregorio F et al. | The influence of gangliosides on neurite growth and regeneration. | 1984 | Neuropediatrics | pmid:6100799 |
| Pampiglione G and Harden A | Neurophysiological investigations in GM1 and GM2 gangliosidoses. | 1984 | Neuropediatrics | pmid:6100798 |
| Schulte FJ | Clinical course of GM2 gangliosidoses. A correlative attempt. | 1984 | Neuropediatrics | pmid:6100797 |
| Li YT et al. | Isolation and characterization of a novel phytosphingosine-containing GM2 ganglioside from mullet roe (Mugil cephalus). | 1984 | J. Biol. Chem. | pmid:6746635 |
| Schwab ME and Vassella F | Synopsis: gangliosidoses. | 1984 | Neuropediatrics | pmid:6100793 |
| Meek D et al. | Juvenile progressive dystonia: a new phenotype of GM2 gangliosidosis. | 1984 | Ann. Neurol. | pmid:6430210 |
| Scheideler MA et al. | Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line. | 1984 | J. Neurochem. | pmid:6422000 |
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Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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