| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Komura N et al. | Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. | 2017 | Meth. Enzymol. | pmid:28935104 |
| Dufresne M et al. | Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry. | 2017 | Anal Bioanal Chem | pmid:27873002 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Trilck M et al. | Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. | 2017 | Brain Res. | pmid:27923633 |
| Worstell NC et al. | Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array. | 2016 | PLoS ONE | pmid:27070150 |
| Kohyama M et al. | In situ detection of GM1 and GM2 gangliosides using immunohistochemical and immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses. | 2016 | BMC Vet. Res. | pmid:27036194 |
| Wolf H et al. | A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. | 2016 | Dis Model Mech | pmid:27491075 |
| Jones PC and Irie RF | Therapeutic Strategies for Human IgM Antibodies Directed at Tumor-Associated Ganglioside Antigens: Discoveries Made During the Morton Era and Future Directions. | 2016 | Crit Rev Oncog | pmid:27481004 |
| Ishigaki H et al. | Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AÂ Case Report and Review of the Literature. | 2016 | Pediatr. Neurol. | pmid:27400822 |
| Tanaka K et al. | Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines. | 2016 | Glycoconj. J. | pmid:27270764 |
| Karumuthil-Melethil S et al. | Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease. | 2016 | Hum. Gene Ther. | pmid:27197548 |
| Kundu M et al. | Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. | 2016 | Biochim. Biophys. Acta | pmid:27066976 |
| Spagnoli C et al. | CMV-associated axonal sensory-motor Guillain-Barré syndrome in a child: Case report and review of the literature. | 2016 | Eur. J. Paediatr. Neurol. | pmid:26621312 |
| Yin Z et al. | Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies. | 2016 | Chembiochem | pmid:26538065 |
| Sikora J et al. | X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities. | 2016 | Dis Model Mech | pmid:26515654 |
| Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
| Grey M et al. | Acceleration of α-synuclein aggregation by exosomes. | 2015 | J. Biol. Chem. | pmid:25425650 |
| Mahata B et al. | GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway. | 2015 | PLoS ONE | pmid:26226135 |
| Anheuser S et al. | Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. | 2015 | J. Lipid Res. | pmid:26175473 |
| Stencel-Baerenwald J et al. | Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. | 2015 | MBio | pmid:25736887 |
| Kano S et al. | Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. | 2015 | Curr. Mol. Med. | pmid:25732146 |
| Vite CH et al. | Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. | 2015 | Sci Transl Med | pmid:25717099 |
| Walia JS et al. | Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates. | 2015 | Mol. Ther. | pmid:25515709 |
| Li Q et al. | Therapeutic activity of glycoengineered anti-GM2 antibodies against malignant pleural mesothelioma. | 2015 | Cancer Sci. | pmid:25421609 |
| Bisel B et al. | GM1 and GM2 gangliosides: recent developments. | 2014 | Biomol Concepts | pmid:25372744 |
| Prendergast J et al. | Ganglioside regulation of AMPA receptor trafficking. | 2014 | J. Neurosci. | pmid:25253868 |
| Abalem MF et al. | Fundus autofluorescence in Tay-Sachs disease. | 2014 | JAMA Ophthalmol | pmid:24852271 |
| Vachalová I et al. | Anti-GM2, -GD1a and -GD1b positive purely isolated facial diplegia. | 2014 | Clin Neurol Neurosurg | pmid:24813327 |
| Krishnamoorthy KS et al. | Case records of the Massachusetts General Hospital. Case 14-2014. An 11-month-old girl with developmental delay. | 2014 | N. Engl. J. Med. | pmid:24806163 |
| Fuller M et al. | Liquid chromatography/electrospray ionisation-tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma. | 2014 | Anal. Biochem. | pmid:24769373 |
| Kang S et al. | Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. | 2014 | Gene | pmid:24534465 |
| Tarhini AA et al. | Serologic evidence of autoimmunity in E2696 and E1694 patients with high-risk melanoma treated with adjuvant interferon alfa. | 2014 | Melanoma Res. | pmid:24509407 |
| Cachón-González MB et al. | Reversibility of neuropathology in Tay-Sachs-related diseases. | 2014 | Hum. Mol. Genet. | pmid:24057669 |
| Mardinoglu A et al. | Integration of clinical data with a genome-scale metabolic model of the human adipocyte. | 2013 | Mol. Syst. Biol. | pmid:23511207 |
| Okawa S et al. | Tolosa-hunt syndrome associated with cytomegalovirus infection. | 2013 | Intern. Med. | pmid:23676602 |
| Eggermont AM et al. | Adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation after resection of primary tumor > 1.5 mm in patients with stage II melanoma: results of the EORTC 18961 randomized phase III trial. | 2013 | J. Clin. Oncol. | pmid:24019551 |
| Li Y et al. | Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23968914 |
| Sato K et al. | Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23765733 |
| Li Y et al. | Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling. | 2013 | Mol. Cell. Biochem. | pmid:23749170 |
| Woods AS et al. | Gangliosides and ceramides change in a mouse model of blast induced traumatic brain injury. | 2013 | ACS Chem Neurosci | pmid:23590251 |
| Rupp A et al. | Anti-GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis. | 2013 | J. Peripher. Nerv. Syst. | pmid:23521648 |
| Sinici I et al. | In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside. | 2013 | PLoS ONE | pmid:23483939 |
| Rupp A et al. | The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice. | 2013 | Synapse | pmid:23401234 |
| Milnik A et al. | Acute inflammatory neuropathy with monoclonal anti-GM2 IgM antibodies, IgM-κ paraprotein and additional autoimmune processes in association with a diffuse large B-cell non-Hodgkin's lymphoma. | 2013 | BMJ Case Rep | pmid:23341581 |
| Yamaguchi T et al. | Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins. | 2013 | Chem. Commun. (Camb.) | pmid:23296043 |
| Sargeant TJ et al. | Characterization of inducible models of Tay-Sachs and related disease. | 2012 | PLoS Genet. | pmid:23028353 |
| Liu F et al. | Molecular and biochemical characterization of a novel β-N-acetyl-D-hexosaminidase with broad substrate-spectrum from the Aisan corn borer, Ostrinia furnacalis. | 2012 | Int. J. Biol. Sci. | pmid:22991497 |
| Kim CS et al. | Functional interaction analysis of GM1-related carbohydrates and Vibrio cholerae toxins using carbohydrate microarray. | 2012 | Anal. Chem. | pmid:22770420 |
| Hoshino T et al. | Simultaneous development of acute disseminated encephalomyelitis and Guillain-Barré syndrome associated with H1N1 09 influenza vaccination. | 2012 | Intern. Med. | pmid:22728497 |
| Pernber Z et al. | Altered distribution of the gangliosides GM1 and GM2 in Alzheimer's disease. | 2012 | Dement Geriatr Cogn Disord | pmid:22572791 |
| Wilkinson FL et al. | Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB. | 2012 | PLoS ONE | pmid:22558223 |
| Keilani S et al. | Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide. | 2012 | J. Neurosci. | pmid:22496568 |
| Dawson G et al. | Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain. | 2012 | Neurochem. Res. | pmid:22484966 |
| Saito M et al. | Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain. | 2012 | J. Neurochem. | pmid:22372857 |
| Arthur JR et al. | Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice. | 2012 | Neurochem. Res. | pmid:22367451 |
| Nagahori N et al. | Use of carbohydrate-conjugated nanoparticles for an integrated approach to functional imaging of glycans and understanding of their molecular mechanisms. | 2012 | Curr Pharm Biotechnol | pmid:22039811 |
| Whitehead B et al. | Experiences of dying, death and bereavement in motor neurone disease: a qualitative study. | 2012 | Palliat Med | pmid:21712334 |
| Matsuoka K et al. | Thymic involution and corticosterone level in Sandhoff disease model mice: new aspects the pathogenesis of GM2 gangliosidosis. | 2011 | J. Inherit. Metab. Dis. | pmid:21598013 |
| Kodama T et al. | Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease. | 2011 | PLoS ONE | pmid:22205997 |
| Passos O et al. | QM/MM study of the catalytic mechanism of GalNAc removal from GM2 ganglioside catalyzed by human β-hexosaminidaseA. | 2011 | J Phys Chem B | pmid:22035098 |
| Klisch K et al. | The Sda/GM2-glycan is a carbohydrate marker of porcine primordial germ cells and of a subpopulation of spermatogonia in cattle, pigs, horses and llama. | 2011 | Reproduction | pmid:21896636 |
| Yamada T et al. | Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells. | 2011 | Cancer Sci. | pmid:21895875 |
| Smyth KA et al. | Acquired infantile abducens palsy associated with anti-GM2 antibodies. | 2011 | Pediatr. Neurol. | pmid:21555058 |
| Tetala KK et al. | Selective depletion of neuropathy-related antibodies from human serum by monolithic affinity columns containing ganglioside mimics. | 2011 | J. Med. Chem. | pmid:21488704 |
| Matsuoka K et al. | Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis. | 2011 | Mol. Ther. | pmid:21487393 |
| Fernández-Marrero Y et al. | Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody. | 2011 | Mol. Immunol. | pmid:21306777 |
| Cronin S et al. | Anti-glycolipid GM2-positive Guillain-Barre syndrome due to hepatitis E infection. | 2011 | Ir J Med Sci | pmid:21063804 |
| Hovakimyan M et al. | Morphological alterations of the cornea in the mouse model of niemann-pick disease type c1. | 2011 | Cornea | pmid:21317782 |
| Denny CA et al. | Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. | 2010 | J. Neurochem. | pmid:20374428 |
| Torres PA et al. | Tay-Sachs disease in Jacob sheep. | 2010 | Mol. Genet. Metab. | pmid:20817517 |
| Seyrantepe V et al. | Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. | 2010 | PLoS Genet. | pmid:20862357 |
| Macauley MS et al. | Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. | 2010 | Chem. Biol. | pmid:20851344 |
| Guan F et al. | Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}. | 2010 | FASEB J. | pmid:20720159 |
| Matsuoka K et al. | Introduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease. | 2010 | Mol. Ther. | pmid:20571546 |
| Vitner EB et al. | Common and uncommon pathogenic cascades in lysosomal storage diseases. | 2010 | J. Biol. Chem. | pmid:20430897 |
| Ho CW et al. | Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. | 2010 | ACS Chem. Biol. | pmid:20187655 |
| Batista L et al. | Induced secretion of beta-hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease? | 2010 | Neurobiol. Dis. | pmid:20005954 |
| Tropak MB et al. | A sensitive fluorescence-based assay for monitoring GM2 ganglioside hydrolysis in live patient cells and their lysates. | 2010 | Glycobiology | pmid:19917668 |
| Tomioka R et al. | Neuroblastoma GOTO cells are hypersensitive to disruption of lipid rafts. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19706290 |
| Susuki K et al. | A Guillain-Barré syndrome variant with prominent facial diplegia. | 2009 | J. Neurol. | pmid:19633904 |
| Takimoto K et al. | Storage of gangliosides GM2 and fucosyl GM1 in the kidney of MCC strain of mastomys (Praomys coucha). | 2009 | J. Biochem. | pmid:19556222 |
| Santos GarcÃa D et al. | Multiple cranial neuropathy associated with herpes simplex virus infection and anti-GM2 immunoglobulin M antibodies. | 2009 | J Clin Neuromuscul Dis | pmid:19494732 |
| Guan F et al. | Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19380734 |
| Loly JP et al. | Guillain-Barré syndrome following hepatitis E. | 2009 | World J. Gastroenterol. | pmid:19340910 |
| Kyrkanides S et al. | The trigeminal retrograde transfer pathway in the treatment of neurodegeneration. | 2009 | J. Neuroimmunol. | pmid:19278737 |
| Ortiz N et al. | Effect of anti-GM2 antibodies on rat sciatic nerve: electrophysiological and morphological study. | 2009 | J. Neuroimmunol. | pmid:19232749 |
| Bay S et al. | Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide. | 2009 | ChemMedChem | pmid:19226501 |
| Stubbs KA et al. | A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19130519 |
| Tanabe A et al. | Obesity causes a shift in metabolic flow of gangliosides in adipose tissues. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19116132 |
| Kondo Y et al. | Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. | 2009 | Biochem. Biophys. Res. Commun. | pmid:18996356 |
| Li H et al. | GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice. | 2008 | J. Lipid Res. | pmid:18450647 |
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Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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