| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Mundel TM et al. | Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells. | 1999 | J. Am. Soc. Nephrol. | pmid:10073593 |
| Khalili-Shirazi A et al. | Antiganglioside antibodies in Guillain-Barré syndrome after a recent cytomegalovirus infection. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10084538 |
| Li YT et al. | Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation. | 1999 | J. Biol. Chem. | pmid:10187778 |
| Mizutani K et al. | Enhancement of TNF-alpha production by ganglioside GM2 in human mononuclear cell culture. | 1999 | Neuroreport | pmid:10208534 |
| Raghavan S et al. | G(M2)-ganglioside metabolism in situ in mucolipidosis IV fibroblasts. | 1999 | Neurochem. Res. | pmid:10227679 |
| Kemp SF and Stoolmiller AC | Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells. Precursor-product relationships among sialoglycosphingolipids. | 1976 | J. Biol. Chem. | pmid:1033935 |
| Cavanna B et al. | Anti-GM2 IgM antibodies: clinical correlates and reactivity with a human neuroblastoma cell line. | 1999 | J. Neuroimmunol. | pmid:10376949 |
| Ecsedy JA et al. | Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice. | 1999 | J. Neurochem. | pmid:10386978 |
| Slevin M et al. | Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. | 1999 | Int. J. Cancer | pmid:10399959 |
| Fukumoto H et al. | Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo. | 1999 | Int. J. Cancer | pmid:10417777 |
| Macias A et al. | Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg). | 1999 | Hybridoma | pmid:10475241 |
| Gori AH et al. | Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. | 1999 | Am. J. Trop. Med. Hyg. | pmid:10497993 |
| Zervas M and Walkley SU | Ferret pyramidal cell dendritogenesis: changes in morphology and ganglioside expression during cortical development. | 1999 | J. Comp. Neurol. | pmid:10502250 |
| Sorice M et al. | Glycosphingolipid domains on cell plasma membrane. | 1999 | Biosci. Rep. | pmid:10513897 |
| Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
| Okada N and Okada H | Human IgM antibody therapy for HIV-1 infection. | 1999 | Microbiol. Immunol. | pmid:10524789 |
| Okada N et al. | Human IgM monoclonal antibody to ganglioside GM2 and complement suppress virus propagation in ex vivo cultures of lymphocytes from HIV-1 infected patients. | 1999 | Microbiol. Immunol. | pmid:10529115 |
| Zuberbier T et al. | Alterations in ganglioside expression during the differentiation of human mast cells. | 1999 | Exp. Dermatol. | pmid:10536964 |
| Nakamura K et al. | Apoptosis induction of human lung cancer cell line in multicellular heterospheroids with humanized antiganglioside GM2 monoclonal antibody. | 1999 | Cancer Res. | pmid:10537316 |
| Bierfreund U et al. | Sphingolipid hydrolases and activator proteins. | 2000 | Meth. Enzymol. | pmid:10563332 |
| Mahuran DJ | Biochemical consequences of mutations causing the GM2 gangliosidoses. | 1999 | Biochim. Biophys. Acta | pmid:10571007 |
| Holmgren J et al. | Interaction of cholera toxin and membrane GM1 ganglioside of small intestine. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1058471 |
| Pospisil M et al. | Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1. | 2000 | Int. J. Oncol. | pmid:10639569 |
| Brezicka T et al. | Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues. | 2000 | Lung Cancer | pmid:10704706 |
| Ang CW et al. | Campylobacter jejuni lipopolysaccharides from Guillain-Barré syndrome patients induce IgG anti-GM1 antibodies in rabbits. | 2000 | J. Neuroimmunol. | pmid:10713352 |
| Chapman PB et al. | Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: a dose-response study. | 2000 | Clin. Cancer Res. | pmid:10741710 |
| Ang CW et al. | Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barré syndrome. | 2000 | Neurology | pmid:10751257 |
| Tsurifune T et al. | Alteration of tumor phenotypes of B16 melanoma after genetic remodeling of the ganglioside profile. | 2000 | Int. J. Oncol. | pmid:10853034 |
| Kosanke SD et al. | Clinical and biochemical abnormalities in porcine GM2-gangliosidosis. | 1978 | Vet. Pathol. | pmid:108843 |
| Wu X et al. | The IgM antibody level against ganglioside GM2 correlates to the disease status of HIV-1-infected patients. | 2000 | Microbiol. Immunol. | pmid:10888361 |
| Kolter T et al. | Recent advances in the biochemistry of glycosphingolipid metabolism. | 1999 | Biochem. Soc. Trans. | pmid:10917612 |
| Portoukalian J | Immunogenicity of glycolipids. | 2000 | Clin Rev Allergy Immunol | pmid:11064828 |
| Chiavegatto S et al. | A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice. | 2000 | Exp. Neurol. | pmid:11085888 |
| Chapman PB et al. | Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine: a trial comparing doses of G(D2)-keyhole limpet hemocyanin. | 2000 | Clin. Cancer Res. | pmid:11156217 |
| Mattson MP | New blood cells help an overburdened brain. | 2001 | Trends Neurosci. | pmid:11163874 |
| Kaida K et al. | Guillain-Barré syndrome with IgM antibody to the ganglioside GalNAc-GD1a. | 2001 | J. Neuroimmunol. | pmid:11164910 |
| Zervas M et al. | Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations. | 2001 | J. Neuropathol. Exp. Neurol. | pmid:11202175 |
| Kirkwood JM et al. | High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: results of the Multicenter Eastern Cooperative Oncology Group Phase II Trial E2696. | 2001 | J. Clin. Oncol. | pmid:11230488 |
| Cavanna B et al. | Anti-GM(2) IgM antibody-induced complement-mediated cytotoxicity in patients with dysimmune neuropathies. | 2001 | J. Neuroimmunol. | pmid:11240036 |
| Ang CW et al. | Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits. | 2001 | Infect. Immun. | pmid:11254608 |
| Parajuli P et al. | Humanized anti-ganglioside GM2 antibody is effective to induce antibody-dependent cell-mediated cytotoxicity in mononuclear cells from lung cancer patients. | 2001 | Cancer Lett. | pmid:11275367 |
| Werth N et al. | Degradation of membrane-bound ganglioside GM2 by beta -hexosaminidase A. Stimulation by GM2 activator protein and lysosomal lipids. | 2001 | J. Biol. Chem. | pmid:11278374 |
| Kirkwood JM et al. | High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. | 2001 | J. Clin. Oncol. | pmid:11331315 |
| Yoshida S et al. | Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. | 2001 | Cancer Res. | pmid:11358851 |
| Saito M and Sugiyama K | Gangliosides in rat kidney: composition, distribution, and developmental changes. | 2001 | Arch. Biochem. Biophys. | pmid:11360994 |
| Nakamura K et al. | Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody. | 2000 | Mol. Immunol. | pmid:11399321 |
| Op Den Velde W and Hooghwinkel GJ | The brain ganglioside pattern in presenile and senile dementia. | 1975 | J Am Geriatr Soc | pmid:1141629 |
| Hedberg KM et al. | Monoclonal anti-GD3 antibodies selectively inhibit the proliferation of human malignant glioma cells in vitro. | 2000 | Glycoconj. J. | pmid:11425192 |
| Hanibuchi M et al. | Immunological circumvention of multiple organ metastases of multidrug resistant human small cell lung cancer cells by mouse-human chimeric anti-ganglioside GM2 antibody KM966. | 2000 | Clin. Exp. Metastasis | pmid:11467766 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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