| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Komura N et al. | Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. | 2017 | Meth. Enzymol. | pmid:28935104 |
| Dufresne M et al. | Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry. | 2017 | Anal Bioanal Chem | pmid:27873002 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Trilck M et al. | Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. | 2017 | Brain Res. | pmid:27923633 |
| Worstell NC et al. | Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array. | 2016 | PLoS ONE | pmid:27070150 |
| Kohyama M et al. | In situ detection of GM1 and GM2 gangliosides using immunohistochemical and immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses. | 2016 | BMC Vet. Res. | pmid:27036194 |
| Wolf H et al. | A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. | 2016 | Dis Model Mech | pmid:27491075 |
| Jones PC and Irie RF | Therapeutic Strategies for Human IgM Antibodies Directed at Tumor-Associated Ganglioside Antigens: Discoveries Made During the Morton Era and Future Directions. | 2016 | Crit Rev Oncog | pmid:27481004 |
| Ishigaki H et al. | Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AÂ Case Report and Review of the Literature. | 2016 | Pediatr. Neurol. | pmid:27400822 |
| Tanaka K et al. | Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines. | 2016 | Glycoconj. J. | pmid:27270764 |
| Karumuthil-Melethil S et al. | Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease. | 2016 | Hum. Gene Ther. | pmid:27197548 |
| Kundu M et al. | Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. | 2016 | Biochim. Biophys. Acta | pmid:27066976 |
| Spagnoli C et al. | CMV-associated axonal sensory-motor Guillain-Barré syndrome in a child: Case report and review of the literature. | 2016 | Eur. J. Paediatr. Neurol. | pmid:26621312 |
| Yin Z et al. | Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies. | 2016 | Chembiochem | pmid:26538065 |
| Sikora J et al. | X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities. | 2016 | Dis Model Mech | pmid:26515654 |
| Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
| Grey M et al. | Acceleration of α-synuclein aggregation by exosomes. | 2015 | J. Biol. Chem. | pmid:25425650 |
| Mahata B et al. | GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway. | 2015 | PLoS ONE | pmid:26226135 |
| Anheuser S et al. | Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. | 2015 | J. Lipid Res. | pmid:26175473 |
| Stencel-Baerenwald J et al. | Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. | 2015 | MBio | pmid:25736887 |
| Kano S et al. | Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. | 2015 | Curr. Mol. Med. | pmid:25732146 |
| Vite CH et al. | Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. | 2015 | Sci Transl Med | pmid:25717099 |
| Walia JS et al. | Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates. | 2015 | Mol. Ther. | pmid:25515709 |
| Li Q et al. | Therapeutic activity of glycoengineered anti-GM2 antibodies against malignant pleural mesothelioma. | 2015 | Cancer Sci. | pmid:25421609 |
| Bisel B et al. | GM1 and GM2 gangliosides: recent developments. | 2014 | Biomol Concepts | pmid:25372744 |
| Prendergast J et al. | Ganglioside regulation of AMPA receptor trafficking. | 2014 | J. Neurosci. | pmid:25253868 |
| Abalem MF et al. | Fundus autofluorescence in Tay-Sachs disease. | 2014 | JAMA Ophthalmol | pmid:24852271 |
| Vachalová I et al. | Anti-GM2, -GD1a and -GD1b positive purely isolated facial diplegia. | 2014 | Clin Neurol Neurosurg | pmid:24813327 |
| Krishnamoorthy KS et al. | Case records of the Massachusetts General Hospital. Case 14-2014. An 11-month-old girl with developmental delay. | 2014 | N. Engl. J. Med. | pmid:24806163 |
| Fuller M et al. | Liquid chromatography/electrospray ionisation-tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma. | 2014 | Anal. Biochem. | pmid:24769373 |
| Kang S et al. | Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. | 2014 | Gene | pmid:24534465 |
| Tarhini AA et al. | Serologic evidence of autoimmunity in E2696 and E1694 patients with high-risk melanoma treated with adjuvant interferon alfa. | 2014 | Melanoma Res. | pmid:24509407 |
| Cachón-González MB et al. | Reversibility of neuropathology in Tay-Sachs-related diseases. | 2014 | Hum. Mol. Genet. | pmid:24057669 |
| Mardinoglu A et al. | Integration of clinical data with a genome-scale metabolic model of the human adipocyte. | 2013 | Mol. Syst. Biol. | pmid:23511207 |
| Okawa S et al. | Tolosa-hunt syndrome associated with cytomegalovirus infection. | 2013 | Intern. Med. | pmid:23676602 |
| Eggermont AM et al. | Adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation after resection of primary tumor > 1.5 mm in patients with stage II melanoma: results of the EORTC 18961 randomized phase III trial. | 2013 | J. Clin. Oncol. | pmid:24019551 |
| Li Y et al. | Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23968914 |
| Sato K et al. | Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23765733 |
| Li Y et al. | Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling. | 2013 | Mol. Cell. Biochem. | pmid:23749170 |
| Woods AS et al. | Gangliosides and ceramides change in a mouse model of blast induced traumatic brain injury. | 2013 | ACS Chem Neurosci | pmid:23590251 |
| Rupp A et al. | Anti-GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis. | 2013 | J. Peripher. Nerv. Syst. | pmid:23521648 |
| Sinici I et al. | In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside. | 2013 | PLoS ONE | pmid:23483939 |
| Rupp A et al. | The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice. | 2013 | Synapse | pmid:23401234 |
| Milnik A et al. | Acute inflammatory neuropathy with monoclonal anti-GM2 IgM antibodies, IgM-κ paraprotein and additional autoimmune processes in association with a diffuse large B-cell non-Hodgkin's lymphoma. | 2013 | BMJ Case Rep | pmid:23341581 |
| Yamaguchi T et al. | Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins. | 2013 | Chem. Commun. (Camb.) | pmid:23296043 |
| Dawson G et al. | Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain. | 2012 | Neurochem. Res. | pmid:22484966 |
| Saito M et al. | Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain. | 2012 | J. Neurochem. | pmid:22372857 |
| Arthur JR et al. | Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice. | 2012 | Neurochem. Res. | pmid:22367451 |
| Nagahori N et al. | Use of carbohydrate-conjugated nanoparticles for an integrated approach to functional imaging of glycans and understanding of their molecular mechanisms. | 2012 | Curr Pharm Biotechnol | pmid:22039811 |
| Whitehead B et al. | Experiences of dying, death and bereavement in motor neurone disease: a qualitative study. | 2012 | Palliat Med | pmid:21712334 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.