| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burg J et al. | Mapping of the gene coding for the human GM2 activator protein to chromosome 5. | 1985 | Ann. Hum. Genet. | pmid:3865618 |
| Navon R et al. | Hereditary heat-labile hexosaminidase B: a variant whose homozygotes synthesize a functional HEX A. | 1985 | Am. J. Hum. Genet. | pmid:3156493 |
| Wenger DA | Diagnosis of atypical patients with lipid storage diseases. | 1985 | Brain Dev. | pmid:4014607 |
| Li SC et al. | Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide. | 1985 | J. Biol. Chem. | pmid:2981875 |
| Dawson G et al. | Regulation of GM2 ganglioside metabolism in cultured cells. | 1986 | Chem. Phys. Lipids | pmid:3549015 |
| Wynn CH and Robson B | Calculation of the conformation of glycosphingolipids. 2. GM1- and GM2-gangliosides. | 1986 | J. Theor. Biol. | pmid:3626589 |
| Sugimoto M et al. | Total synthesis of gangliosides GM1 and GM2. | 1986 | Carbohydr. Res. | pmid:3815403 |
| Natoli EJ et al. | A murine monoclonal antibody detecting N-acetyl- and N-glycolyl-GM2: characterization of cell surface reactivity. | 1986 | Cancer Res. | pmid:3731079 |
| Cavaillon JM et al. | Ganglioside identification on human monocyte membrane with Clostridium perfringens delta-toxin. | 1986 | J. Leukoc. Biol. | pmid:2872258 |
| Zeigler M and Bach G | Internalization of exogenous gangliosides in cultured skin fibroblasts for the diagnosis of mucolipidosis IV. | 1986 | Clin. Chim. Acta | pmid:3087662 |
| Charrow J and Binns HJ | Ganglioside loading of cultured fibroblasts: a provocative method for the diagnosis of the GM2 gangliosidoses. | 1986 | Clin. Chim. Acta | pmid:2938852 |
| Kotagal S et al. | AB variant GM2 gangliosidosis: cerebrospinal fluid and neuropathologic characteristics. | 1986 | Neurology | pmid:3081832 |
| Dahiya R and Brasitus TA | Glycosphingolipid patterns of fetal and adult small intestinal mucosa in the sheep. | 1986 | Biochim. Biophys. Acta | pmid:3942764 |
| Kotagal S | Diagnosis of AB variant, GM2 gangliosidosis. | 1986 | Ann. Neurol. | pmid:3080943 |
| Miyagi T and Tsuiki S | Evidence for sialidase hydrolyzing gangliosides GM2 and GM1 in rat liver plasma membrane. | 1986 | FEBS Lett. | pmid:3758350 |
| Oates CE et al. | Movement disorders associated with chronic GM2 gangliosidosis. Case report and review of the literature. | 1986 | Eur. Neurol. | pmid:3081350 |
| Ishikawa Y et al. | Biochemical basis of type AB GM2 gangliosidosis in a Japanese spaniel. | 1987 | J. Neurochem. | pmid:2949061 |
| Li YT et al. | Occurrence of ceramide-glycanase in the earthworm, Lumbricus terrestris. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3689409 |
| Nagai K and Ishizuka I | Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain. | 1987 | J. Biochem. | pmid:3115968 |
| Naoi M et al. | Ganglioside GM1 causes expression of type B monoamine oxidase in a rat clonal pheochromocytoma cell line, PC12h. | 1987 | J. Neurochem. | pmid:3117976 |
| Rosengren B et al. | Composition of gangliosides and neutral glycosphingolipids of brain in classical Tay-Sachs and Sandhoff disease: more lyso-GM2 in Sandhoff disease? | 1987 | J. Neurochem. | pmid:3612128 |
| Eto Y et al. | Partial deficiency of beta-hexosaminidase activity in canine GM2-gangliosidosis. | 1987 | Tohoku J. Exp. Med. | pmid:2958961 |
| Yamanaka T et al. | Detection of gangliotriaose-series glycosphingolipids in serum of cord blood and patients with neuroblastoma by a sensitive TLC/enzyme-immunostaining method. | 1987 | Biochim. Biophys. Acta | pmid:3300782 |
| Ando I et al. | Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells. | 1987 | Int. J. Cancer | pmid:3596830 |
| Yanagisawa K et al. | Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver. | 1987 | Biochim. Biophys. Acta | pmid:3109491 |
| Harding AE et al. | Adult onset supranuclear ophthalmoplegia, cerebellar ataxia, and neurogenic proximal muscle weakness in a brother and sister: another hexosaminidase A deficiency syndrome. | 1987 | J. Neurol. Neurosurg. Psychiatry | pmid:2956362 |
| Livingston PO et al. | Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3472242 |
| Livingston PO et al. | Approaches to augmenting the immunogenicity of the ganglioside GM2 in mice: purified GM2 is superior to whole cells. | 1987 | J. Immunol. | pmid:3805726 |
| Ilyas AA et al. | Gangliosides GM2, IV4GalNAcGM1b, and IV4GalNAcGC1a as antigens for monoclonal immunoglobulin M in neuropathy associated with gammopathy. | 1988 | J. Biol. Chem. | pmid:2450092 |
| Sanai Y et al. | Monoclonal antibody directed to a Hanganutziu-Deicher active ganglioside, GM2 (NeuGc). | 1988 | Biochim. Biophys. Acta | pmid:2449247 |
| Jolivet-Reynaud C et al. | Damaging effects of Clostridium perfringens delta toxin on blood platelets and their relevance to ganglioside GM2. | 1988 | Arch. Biochem. Biophys. | pmid:3162668 |
| Kushi Y et al. | Direct analysis of glycolipids on thin-layer plates by matrix-assisted secondary ion mass spectrometry: application for glycolipid storage disorders. | 1988 | Anal. Biochem. | pmid:3149874 |
| Miyake M et al. | Generation of two murine monoclonal antibodies that can discriminate N-glycolyl and N-acetyl neuraminic acid residues of GM2 gangliosides. | 1988 | Cancer Res. | pmid:3167861 |
| Tanaka A et al. | GM2-gangliosidosis B1 variant: a wide geographic and ethnic distribution of the specific beta-hexosaminidase alpha chain mutation originally identified in a Puerto Rican patient. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2973311 |
| Lichtenberg P et al. | Post-partum psychosis in adult GM2 gangliosidosis. A case report. | 1988 | Br J Psychiatry | pmid:2977954 |
| Budde-Steffen C et al. | Presence of beta-hexosaminidase A alpha-chain mRNA in two different variants of GM2-gangliosidosis. | 1988 | Neuropediatrics | pmid:2967444 |
| Torres BV et al. | Glycolipid-lectin interactions: reactivity of lectins from Helix pomatia, Wisteria floribunda, and Dolichos biflorus with glycolipids containing N-acetylgalactosamine. | 1988 | Arch. Biochem. Biophys. | pmid:3355161 |
| Naoi M et al. | Specific binding of glycosylated beta-galactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides. | 1988 | J. Neurochem. | pmid:3126266 |
| DeGasperi R et al. | A GM2-specific beta-hexosaminidase from the roe of striped mullet (Mugil cephalus). | 1988 | J. Biol. Chem. | pmid:2961751 |
| Ohno K and Suzuki K | Mutation in GM2-gangliosidosis B1 variant. | 1988 | J. Neurochem. | pmid:2961848 |
| Baba H et al. | Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. | 1989 | J. Neuroimmunol. | pmid:2584393 |
| Singer HS and Cork LC | Canine GM2 gangliosidosis: morphological and biochemical analysis. | 1989 | Vet. Pathol. | pmid:2540585 |
| Livingston PO et al. | Characterization of IgG and IgM antibodies induced in melanoma patients by immunization with purified GM2 ganglioside. | 1989 | Cancer Res. | pmid:2582446 |
| Zvezdina ND et al. | Gangliosides of sea urchin embryos. Their localization and participation in early development. | 1989 | Eur. J. Biochem. | pmid:2598928 |
| Vrionis FD et al. | Five new epitope-defined monoclonal antibodies reactive with GM2 and human glioma and medulloblastoma cell lines. | 1989 | Cancer Res. | pmid:2479468 |
| Ghidoni R et al. | Metabolism of exogenous gangliosides in cerebellar granule cells, differentiated in culture. | 1989 | J. Neurochem. | pmid:2795018 |
| Dotta F et al. | Ganglioside expression in human pancreatic islets. | 1989 | Diabetes | pmid:2695376 |
| Fredman P et al. | A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium. | 1989 | J. Biol. Chem. | pmid:2473071 |
| Schröder M et al. | Isolation of a cDNA encoding the human GM2 activator protein. | 1989 | FEBS Lett. | pmid:2753159 |
| DeGasperi R et al. | Isolation and characterization of an activator protein for the hydrolysis of ganglioside GM2 from the roe of striped mullet (Mugil cephalus). | 1989 | Biochem. J. | pmid:2527497 |
| Hoon DS et al. | Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells. | 1989 | Int. J. Cancer | pmid:2714890 |
| Riboni L et al. | Formation of ganglioside GD1b-lactone in rat brain from intracisternally administered GD1b. | 1989 | J. Neurochem. | pmid:2709011 |
| Walton KM and Schnaar RL | Coordinate regulation of ganglioside glycosyltransferases in differentiating NG108-15 neuroblastoma x glioma cells. | 1989 | J. Neurochem. | pmid:2540274 |
| Hechtman P et al. | The mutation mechanism causing juvenile-onset Tay-Sachs disease among Lebanese. | 1989 | Clin. Genet. | pmid:2527097 |
| Irie RF et al. | Human monoclonal antibody to ganglioside GM2 for melanoma treatment. | 1989 | Lancet | pmid:2564593 |
| Paw BH et al. | Molecular basis of adult-onset and chronic GM2 gangliosidoses in patients of Ashkenazi Jewish origin: substitution of serine for glycine at position 269 of the alpha-subunit of beta-hexosaminidase. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2522660 |
| Mitsuo K et al. | Juvenile Sandhoff disease: a Japanese patient carrying a mutation identical to that found earlier in a Canadian patient. | 1990 | J. Neurol. Sci. | pmid:2147031 |
| Yoshino H et al. | Abnormal glycosphingolipid metabolism in the nervous system of galactosialidosis. | 1990 | J. Neurol. Sci. | pmid:2115076 |
| Hanisch FG et al. | Glycosphingolipid expression on murine L1-fibrosarcoma cells: analysis of clonal in vivo and in vitro selected sublines with different lung colonisation potential. | 1990 | Br. J. Cancer | pmid:2372482 |
| Tonevitsky AG et al. | Effect of gangliosides on binding, internalization and cytotoxic activity of ricin. | 1990 | FEBS Lett. | pmid:2358071 |
| Trinchera M and Ghidoni R | Precursor-product relationship between GM1 and GD1a biosynthesized from exogenous GM2 ganglioside in rat liver. | 1990 | J. Biochem. | pmid:2358435 |
| Mahuran DJ et al. | The molecular basis of Tay-Sachs disease: mutation identification and diagnosis. | 1990 | Clin. Biochem. | pmid:2147596 |
| Trinchera M et al. | The N-acetylgalactosamine residue of exogenous GM2 ganglioside is recycled for glycoconjugate biosynthesis in rat liver. | 1990 | Biochem. J. | pmid:2310367 |
| Fürst W et al. | The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein. | 1990 | Eur. J. Biochem. | pmid:2209618 |
| Cantù L et al. | Evidence for spontaneous segregation phenomena in mixed micelles of gangliosides. | 1990 | Chem. Phys. Lipids | pmid:2289284 |
| Paw BH et al. | Juvenile GM2 gangliosidosis caused by substitution of histidine for arginine at position 499 or 504 of the alpha-subunit of beta-hexosaminidase. | 1990 | J. Biol. Chem. | pmid:2140574 |
| Dohi T et al. | Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosa. | 1990 | J. Biol. Chem. | pmid:2139874 |
| Yamaguchi H et al. | Human monoclonal antibody with dual GM2/GD2 specificity derived from an immunized melanoma patient. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2159145 |
| Karlsson G et al. | Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2. | 1990 | Biochim. Biophys. Acta | pmid:1691018 |
| Navon R et al. | Ashkenazi-Jewish and non-Jewish adult GM2 gangliosidosis patients share a common genetic defect. | 1990 | Am. J. Hum. Genet. | pmid:2278539 |
| Miyake M et al. | The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors. A study with specific monoclonal antibodies. | 1990 | Cancer | pmid:2153431 |
| Nakamura K et al. | Genetic regulation of GM4(NeuAc) expression in mouse erythrocytes. | 1990 | J. Biochem. | pmid:2332419 |
| Navon R | Molecular and clinical heterogeneity of adult GM2 gangliosidosis. | 1991 | Dev. Neurosci. | pmid:1840100 |
| Suzuki K and Vanier MT | Biochemical and molecular aspects of late-onset GM2-gangliosidosis: B1 variant as a prototype. | 1991 | Dev. Neurosci. | pmid:1840099 |
| Federico A et al. | The clinical aspects of adult hexosaminidase deficiencies. | 1991 | Dev. Neurosci. | pmid:1840098 |
| Goodman LA et al. | Ectopic dendrites occur only on cortical pyramidal cells containing elevated GM2 ganglioside in alpha-mannosidosis. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1763046 |
| Dohi T et al. | Localization of UDP-GalNAc:NeuAc alpha 2,3Gal-R beta 1,4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human stomach. Enzymatic synthesis of a fundic gland-specific ganglioside and GM2. | 1991 | J. Biol. Chem. | pmid:1748676 |
| Chen S et al. | Quantitative analysis of the molecular species of monosialogangliosides by continuous-flow fast-atom bombardment mass spectrometry. | 1991 | Rapid Commun. Mass Spectrom. | pmid:1811797 |
| dos Santos MR et al. | GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene mutations in 11 patients from a defined region in Portugal. | 1991 | Am. J. Hum. Genet. | pmid:1832817 |
| Nakamura M et al. | Radioimmune assay of sialyltransferase and N-acetylgalactosaminyltransferase activities using specific antibodies on a 96-well filtration plate of a multiscreen assay system. | 1991 | Anal. Biochem. | pmid:1789418 |
| Schröder M et al. | A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB. | 1991 | FEBS Lett. | pmid:1915858 |
| Klima H et al. | Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein. | 1991 | FEBS Lett. | pmid:1915857 |
| Bjerkvig R et al. | Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line. | 1991 | Cancer Res. | pmid:1873810 |
| Xie B et al. | Isolation and expression of a full-length cDNA encoding the human GM2 activator protein. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2059210 |
| Hoffman LM et al. | SV-40 transformation: effect on GM2 ganglioside in cultured cell lines. | 1991 | Biochim. Biophys. Acta | pmid:1647206 |
| Liu YB and Chan KF | High-performance capillary electrophoresis of gangliosides. | 1991 | Electrophoresis | pmid:1889389 |
| Sindern E et al. | Serum antibodies to GM1 and GM3-gangliosides in systemic lupus erythematosus with chronic inflammatory demyelinating polyradiculoneuropathy. | 1991 | Acta Neurol. Scand. | pmid:1887763 |
| Mahuran DJ | The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis. | 1991 | Biochim. Biophys. Acta | pmid:1825792 |
| Meier EM et al. | The human GM2 activator protein. A substrate specific cofactor of beta-hexosaminidase A. | 1991 | J. Biol. Chem. | pmid:1824846 |
| Kono M et al. | Two pathways for GM2(NeuGc) expression in mice: genetic analysis. | 1991 | J. Biochem. | pmid:2016262 |
| Yavin E et al. | Nerve growth factor mediates monosialoganglioside-induced release of fibronectin and J1/tenascin from C6 glioma cells. | 1991 | J. Neurochem. | pmid:1702827 |
| Obi T et al. | IgM M-protein in a patient with sensory-dominant neuropathy binds preferentially to polysialogangliosides. | 1992 | Acta Neurol. Scand. | pmid:1384262 |
| Schaeper RJ et al. | In vitro biosynthesis of GbOse4Cer (globoside) and GM2 ganglioside by the (1-->3) and (1-->4)-N-acetyl beta-D-galactosaminyltransferases from embryonic chicken brain. Solubilization, purification, and characterization of the transferases. | 1992 | Carbohydr. Res. | pmid:1291049 |
| Xie B et al. | Identification of a processed pseudogene related to the functional gene encoding the GM2 activator protein: localization of the pseudogene to human chromosome 3 and the functional gene to human chromosome 5. | 1992 | Genomics | pmid:1427911 |
| Nagata Y et al. | Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides. | 1992 | J. Biol. Chem. | pmid:1601877 |
| Xie B et al. | A Cys138-to-Arg substitution in the GM2 activator protein is associated with the AB variant form of GM2 gangliosidosis. | 1992 | Am. J. Hum. Genet. | pmid:1570834 |
| Dobrenis K et al. | Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1532255 |
| Renshaw PF et al. | Electroconvulsive therapy treatment of depression in a patient with adult GM2 gangliosidosis. | 1992 | Ann. Neurol. | pmid:1386210 |
| Nakao T et al. | Novel lacto-ganglio type gangliosides with GM2-epitope in bovine brain which react with IgM from a patient of the amyotrophic lateral sclerosis-like disorder. | 1993 | J. Biol. Chem. | pmid:7691804 |
| Yamashiro S et al. | Genetic and enzymatic basis for the differential expression of GM2 and GD2 gangliosides in human cancer cell lines. | 1993 | Cancer Res. | pmid:8221677 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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