| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kyrkanides S et al. | Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. | 2008 | J. Neuroimmunol. | pmid:18657867 |
| Li YT et al. | Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility. | 2008 | Biochim. Biophys. Acta | pmid:17967427 |
| Nobile-Orazio E et al. | How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies? | 2008 | J. Neurol. Sci. | pmid:17915254 |
| Aguilar RP et al. | Renal gangliosides are involved in lead intoxication. | 2008 | J Appl Toxicol | pmid:17503479 |
| Boardman AK et al. | Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry. | 2008 | Anal. Chem. | pmid:18717573 |
| Larsson EA et al. | Synthesis of reference standards to enable single cell metabolomic studies of tetramethylrhodamine-labeled ganglioside GM1. | 2007 | Carbohydr. Res. | pmid:17069778 |
| Gavella M et al. | Antioxidant properties of ganglioside micelles. | 2007 | Free Radic. Res. | pmid:17886036 |
| Alvarez-Rueda N et al. | Binding activities and antitumor properties of a new mouse/human chimeric antibody specific for GD2 ganglioside antigen. | 2007 | Clin. Cancer Res. | pmid:17875797 |
| Raval G et al. | TNF-alpha induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction. | 2007 | J. Immunol. | pmid:17475896 |
| López-Requena A et al. | Gangliosides, Ab1 and Ab2 antibodies III. The idiotype of anti-ganglioside mAb P3 is immunogenic in a T cell-dependent manner. | 2007 | Mol. Immunol. | pmid:17316805 |
| Martinez Z et al. | GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. | 2007 | Biochemistry | pmid:17253773 |
| Todeschini AR et al. | Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. | 2007 | J. Biol. Chem. | pmid:17215249 |
| Kawashima I et al. | Cytochemical analysis of storage materials in cultured skin fibroblasts from patients with I-cell disease. | 2007 | Clin. Chim. Acta | pmid:17204262 |
| Hasegawa D et al. | Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat. | 2007 | J. Feline Med. Surg. | pmid:17198760 |
| Tsuji D et al. | Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies. | 2007 | Clin. Chim. Acta | pmid:17196574 |
| Zhao Y et al. | Endowing self-binding feature restores the activities of a loss-of-function chimerized anti-GM2 antibody. | 2007 | Cancer Immunol. Immunother. | pmid:16896968 |
| López-Requena A et al. | Gangliosides, Ab1 and Ab2 antibodies II. Light versus heavy chain: An idiotype-anti-idiotype case study. | 2007 | Mol. Immunol. | pmid:16620986 |
| Wendeler M et al. | The enzyme-binding region of human GM2-activator protein. | 2006 | FEBS J. | pmid:16478472 |
| Kirvan CA et al. | Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea. | 2006 | Autoimmunity | pmid:16455579 |
| Arfi A et al. | Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase alpha and beta. | 2006 | J. Neurochem. | pmid:16441513 |
| Ledeen RW and Wu G | Gangliosides of the nuclear membrane: a crucial locus of cytoprotective modulation. | 2006 | J. Cell. Biochem. | pmid:16408301 |
| Jacques S et al. | Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications. | 2006 | Org. Biomol. Chem. | pmid:16358009 |
| Kaida K et al. | Anti-ganglioside complex antibodies in Miller Fisher syndrome. | 2006 | J. Neurol. Neurosurg. Psychiatry | pmid:16614007 |
| Usuki S et al. | Molecular mimicry: sensitization of Lewis rats with Campylobacter jejuni lipopolysaccharides induces formation of antibody toward GD3 ganglioside. | 2006 | J. Neurosci. Res. | pmid:16342208 |
| Duan J et al. | Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor'. | 2006 | Arch. Biochem. Biophys. | pmid:16962990 |
| Sakuraba H et al. | Molecular pathologies of and enzyme replacement therapies for lysosomal diseases. | 2006 | CNS Neurol Disord Drug Targets | pmid:16918392 |
| Fuse T et al. | Synthesis and enzymatic susceptibility of a series of novel GM2 analogs. | 2006 | Glycoconj. J. | pmid:16897176 |
| Itakura T et al. | Inefficiency in GM2 ganglioside elimination by human lysosomal beta-hexosaminidase beta-subunit gene transfer to fibroblastic cell line derived from Sandhoff disease model mice. | 2006 | Biol. Pharm. Bull. | pmid:16880605 |
| Crawley AC et al. | Characterization of a C57BL/6 congenic mouse strain of mucopolysaccharidosis type IIIA. | 2006 | Brain Res. | pmid:16828069 |
| Biswas K et al. | GM2 expression in renal cell carcinoma: potential role in tumor-induced T-cell dysfunction. | 2006 | Cancer Res. | pmid:16818659 |
| Thiesen PH et al. | Glycolipids from a colloid chemical point of view. | 2006 | J. Biotechnol. | pmid:16707183 |
| Bruce AF et al. | Functional characterisation of a nematode secreted GM2-activator protein. | 2006 | Mol. Biochem. Parasitol. | pmid:16569450 |
| Yin J et al. | Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. | 2006 | Cancer Res. | pmid:16540641 |
| Ragupathi G et al. | Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. | 2006 | J. Am. Chem. Soc. | pmid:16492059 |
| Kolter T et al. | Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense. | 2005 | J. Biol. Chem. | pmid:16230343 |
| Mencarelli S et al. | Identification of plasma membrane associated mature beta-hexosaminidase A, active towards GM2 ganglioside, in human fibroblasts. | 2005 | FEBS Lett. | pmid:16212960 |
| Martin DR et al. | Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis. | 2005 | Acta Neuropathol. | pmid:16200419 |
| Sango K et al. | Impaired neurite outgrowth in the retina of a murine model of Sandhoff disease. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16123447 |
| Tsuji D et al. | Metabolic correction in microglia derived from Sandhoff disease model mice. | 2005 | J. Neurochem. | pmid:16092933 |
| Schwarzmann G et al. | Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system. | 2005 | Glycobiology | pmid:16079415 |
| Retter MW et al. | Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts. | 2005 | Cancer Res. | pmid:16024647 |
| Blixt O et al. | Chemoenzymatic synthesis of 2-azidoethyl-ganglio-oligosaccharides GD3, GT3, GM2, GD2, GT2, GM1, and GD1a. | 2005 | Carbohydr. Res. | pmid:16005859 |
| Arfi A et al. | Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts. | 2005 | Neurobiol. Dis. | pmid:15953731 |
| Livingston PO et al. | Selection of GM2, fucosyl GM1, globo H and polysialic acid as targets on small cell lung cancers for antibody mediated immunotherapy. | 2005 | Cancer Immunol. Immunother. | pmid:15926079 |
| Fort S et al. | Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli. | 2005 | Chem. Commun. (Camb.) | pmid:15900325 |
| Gieselmann V | What can cell biology tell us about heterogeneity in lysosomal storage diseases? | 2005 | Acta Paediatr Suppl | pmid:15895717 |
| Tsuji D et al. | Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates. | 2005 | J. Neurochem. | pmid:15748167 |
| Santafé MM et al. | Changes in the neuromuscular synapse induced by an antibody against gangliosides. | 2005 | Ann. Neurol. | pmid:15732093 |
| Kyrkanides S et al. | beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710246 |
| Hernández AM et al. | Generation of anti-Neu-glycolyl-ganglioside antibodies by immunization with an anti-idiotype monoclonal antibody: A self versus non-self-matter. | 2005 | Immunobiology | pmid:16076030 |
| Ando T et al. | Facile method for the preparation of lyso-GM1 and lyso-GM2. | 2005 | J Chromatogr A | pmid:16010718 |
| Masson E et al. | Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides. | 2005 | Biochem. J. | pmid:15654767 |
| Moran AP et al. | Antibodies induced by ganglioside-mimicking Campylobacter jejuni lipooligosaccharides recognise epitopes at the nodes of Ranvier. | 2005 | J. Neuroimmunol. | pmid:15993494 |
| Usuki S et al. | AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides. | 2005 | J. Neurol. Sci. | pmid:15850580 |
| Yamato O et al. | GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family of Japanese domestic cats. | 2004 | Vet. Rec. | pmid:15623087 |
| Cressant A et al. | Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum. | 2004 | J. Neurosci. | pmid:15537895 |
| Kunishige M et al. | Isolated cranial neuropathy associated with anti-glycolipid antibodies. | 2004 | J. Neurol. Sci. | pmid:15465085 |
| Aoki H et al. | Inhibition of motility and invasiveness of renal cell carcinoma induced by short interfering RNA transfection of beta 1,4GalNAc transferase. | 2004 | FEBS Lett. | pmid:15178323 |
| Andersen SM et al. | Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome. | 2004 | Org. Biomol. Chem. | pmid:15064799 |
| Higashi H and Chen NH | Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization. | 2004 | Glycoconj. J. | pmid:14973370 |
| Batuwangala T et al. | The crystal structure of human CD1b with a bound bacterial glycolipid. | 2004 | J. Immunol. | pmid:14764708 |
| Wendeler M et al. | Photoaffinity labelling of the human GM2-activator protein. Mechanistic insight into ganglioside GM2 degradation. | 2004 | Eur. J. Biochem. | pmid:14728689 |
| Yamaguchi A et al. | Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. | 2004 | J. Clin. Invest. | pmid:14722612 |
| Yamato O et al. | Laboratory diagnosis of canine GM2-gangliosidosis using blood and cerebrospinal fluid. | 2004 | J. Vet. Diagn. Invest. | pmid:14974845 |
| Krug LM et al. | Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin. | 2004 | Clin. Cancer Res. | pmid:14871967 |
| Wendeler M et al. | Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay. | 2003 | Meth. Enzymol. | pmid:14579597 |
| Li YT et al. | Structural basis for the enzymatic resistance of the GM2 ganglioside. | 2003 | Meth. Enzymol. | pmid:14579580 |
| Mauri L et al. | Procedure for separation of GM2 ganglioside species with different ceramide structures by a flash reversed-phase silica gel liquid chromatography. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14552811 |
| Brown ER and Ibrahim JG | A Bayesian semiparametric joint hierarchical model for longitudinal and survival data. | 2003 | Biometrics | pmid:12926706 |
| Li YT et al. | Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. | 2003 | J. Biol. Chem. | pmid:12829702 |
| Antoine T et al. | Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli. | 2003 | Chembiochem | pmid:12740812 |
| Mizutani K et al. | Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2. | 2003 | Intern. Med. | pmid:12705795 |
| Odaka M and Yuki N | Antibodies to GM2 ganglioside in neurological disorders. | 2003 | Intern. Med. | pmid:12705785 |
| Yamaguchi A et al. | Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease. | 2003 | J. Mol. Med. | pmid:12682727 |
| Rapoport E et al. | Ganglioside binding pattern of CD33-related siglecs. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639556 |
| Shimada Y et al. | Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin. | 2003 | J. Lipid Res. | pmid:12576516 |
| Chen HH et al. | Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene. | 2003 | Int. J. Cancer | pmid:12455030 |
| Sharma R et al. | A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside. | 2003 | Biochim. Biophys. Acta | pmid:12527415 |
| Irie S et al. | Detection of serum anti-ganglioside antibodies by latex agglutination assay in Guillain-Barré syndrome: comparison with ELISA. | 2003 | Intern. Med. | pmid:12857046 |
| Tada M et al. | [Steroid-pulse therapy in Guillain-Barré syndrome associated with cytomegalovirus infection: a case report]. | 2003 | No To Shinkei | pmid:12910997 |
| Pelled D et al. | Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. | 2003 | J. Biol. Chem. | pmid:12756243 |
| Wölfl M et al. | Gangliosides inhibit the development from monocytes to dendritic cells. | 2002 | Clin. Exp. Immunol. | pmid:12452834 |
| Martino S et al. | Restoration of the GM2 ganglioside metabolism in bone marrow-derived stromal cells from Tay-Sachs disease animal model. | 2002 | Neurochem. Res. | pmid:12374215 |
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Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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