| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hechtman P and Kachra Z | Interaction of activating protein and surfactants with human liver hexosaminidase A and GM2 ganglioside. | 1980 | Biochem. J. | pmid:7387624 |
| Hoffman LM et al. | Tay-Sachs disease brain cells in culture: mobilization of stored GM2 after concanavalin A-mediated uptake of hexosaminidase A. | 1980 | J. Neurosci. Res. | pmid:7441795 |
| Hoffman LM et al. | Human fetal brain cells in culture. Increase in GM2 ganglioside after SV-40 transformation. | 1981 | Biochim. Biophys. Acta | pmid:6271225 |
| Li SC et al. | A new variant of type-AB GM2-gangliosidosis. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306091 |
| Pullarkat RK et al. | Accumulation of ganglioside Gm2 in cerebrospinal fluid of a patient with the variant AB of infantile Gm2 gangliosidosis. | 1981 | Pediatrics | pmid:7243492 |
| Li SC et al. | A protein activator for the enzymic hydrolysis of GM2 ganglioside. | 1981 | J. Biol. Chem. | pmid:7240201 |
| Watanabe T et al. | Human melanoma antigen AH is an autoantigenic ganglioside related to GD2. | 1982 | J. Exp. Med. | pmid:7175442 |
| Hasilik A et al. | Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6214395 |
| Poulos A et al. | Diagnosis of Tay-Sachs disease using [3H]N-acetylneuraminic acid labelled GM2 ganglioside as substrate. | 1982 | Clin. Chim. Acta | pmid:6210469 |
| Conzelmann E et al. | Complexing of glycolipids and their transfer between membranes by the activator protein for degradation of lysosomal ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6210531 |
| Hashimoto Y et al. | The occurrence of GM4 and GM2 in erythrocytes from inbred strains of mice. | 1982 | J. Biochem. | pmid:7076644 |
| Riedl M et al. | A ganglioside-dependent cellular binding mechanism in rat macrophages. | 1982 | J. Immunol. | pmid:7073871 |
| Yu RK et al. | Characterization of some minor gangliosides in Tay-Sachs brains. | 1983 | Brain Res. | pmid:6414648 |
| Kniep B et al. | Gangliotriaosylceramide (asialo GM2), a glycosphingolipid marker for cell lines derived from patients with Hodgkin's disease. | 1983 | J. Immunol. | pmid:6886427 |
| Conzelmann E et al. | Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level. | 1983 | Am. J. Hum. Genet. | pmid:6614006 |
| Tai T et al. | Ganglioside GM2 as a human tumor antigen (OFA-I-1). | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6193515 |
| Yusuf HK et al. | Ganglioside biosynthesis in Golgi apparatus of rat liver. Stimulation by phosphatidylglycerol and inhibition by tunicamycin. | 1983 | Eur. J. Biochem. | pmid:6861762 |
| Inui K et al. | Juvenile GM2 gangliosidosis (AMB variant): inability to activate hexosaminidase A by activator protein. | 1983 | Am. J. Hum. Genet. | pmid:6224417 |
| Li YT et al. | Differentiation of two variants of type-AB GM2-gangliosidosis using chromogenic substrates. | 1983 | Am. J. Hum. Genet. | pmid:6222647 |
| Hashimoto Y et al. | Genetic regulation of GM2 expression in liver of mouse. | 1983 | J. Biochem. | pmid:6874670 |
| Kaplan F and Hechtman P | Purification and properties of two enzymes catalyzing galactose transfer to GM2 ganglioside from rat liver Golgi. | 1983 | J. Biol. Chem. | pmid:6401719 |
| Hirabayashi Y et al. | The protein activator specific for the enzymic hydrolysis of GM2 ganglioside in normal human brain and brains of three types of GM2 gangliosidosis. | 1983 | J. Neurochem. | pmid:6848657 |
| Young WW et al. | Decreased glycolipid antigen expression in lymphoma cell variants escaping from anti-glycolipid serotherapy. | 1983 | J. Exp. Med. | pmid:6848617 |
| Harzer K | Assay of the GM2-ganglioside cleaving hexosaminidase activity of skin fibroblasts for GM2-gangliosidoses. | 1983 | Clin. Chim. Acta | pmid:6228344 |
| Seyfried TN et al. | Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. | 1984 | J. Neurochem. | pmid:6470710 |
| Sandhoff K and Conzelmann E | The biochemical basis of gangliosidoses. | 1984 | Neuropediatrics | pmid:6242704 |
| Goebel HH | Morphology of the gangliosidoses. | 1984 | Neuropediatrics | pmid:6100800 |
| Di Gregorio F et al. | The influence of gangliosides on neurite growth and regeneration. | 1984 | Neuropediatrics | pmid:6100799 |
| Pampiglione G and Harden A | Neurophysiological investigations in GM1 and GM2 gangliosidoses. | 1984 | Neuropediatrics | pmid:6100798 |
| Schulte FJ | Clinical course of GM2 gangliosidoses. A correlative attempt. | 1984 | Neuropediatrics | pmid:6100797 |
| Li YT et al. | Isolation and characterization of a novel phytosphingosine-containing GM2 ganglioside from mullet roe (Mugil cephalus). | 1984 | J. Biol. Chem. | pmid:6746635 |
| Schwab ME and Vassella F | Synopsis: gangliosidoses. | 1984 | Neuropediatrics | pmid:6100793 |
| Meek D et al. | Juvenile progressive dystonia: a new phenotype of GM2 gangliosidosis. | 1984 | Ann. Neurol. | pmid:6430210 |
| Scheideler MA et al. | Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line. | 1984 | J. Neurochem. | pmid:6422000 |
| Itoh H et al. | The fine structure of cytoplasmic inclusions in brain and other visceral organs in Sandhoff disease. | 1984 | Brain Dev. | pmid:6097133 |
| Kadowaki H et al. | Separation of brain monosialoganglioside molecular species by high-performance liquid chromatography. | 1984 | J. Lipid Res. | pmid:6512419 |
| Fishman PH et al. | The role of gangliosides in the interaction of human chorionic gonadotropin and cholera toxin with murine Leydig tumor cells. | 1984 | J. Biol. Chem. | pmid:6330091 |
| Li SC et al. | Effect of modification of sialic acid on enzymic hydrolysis of gangliosides GM1 and GM2. | 1984 | J. Biol. Chem. | pmid:6232275 |
| Nojiri H et al. | Characteristic expression of glycosphingolipid profiles in the bipotential cell differentiation of human promyelocytic leukemia cell line HL-60. | 1984 | Blood | pmid:6589019 |
| Higashi H et al. | Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer. | 1985 | Cancer Res. | pmid:3874688 |
| Iwamori M et al. | Brain gangliosides of quaking and shiverer mutants: qualitative and quantitative changes of monosialogangliosides in the quaking brain. | 1985 | J. Neurochem. | pmid:3998734 |
| Kytzia HJ and Sandhoff K | Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A. | 1985 | J. Biol. Chem. | pmid:3158659 |
| Kasai N et al. | Preparation and specificity of avian anti-GM2(NeuGc) ganglioside antiserum. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3925943 |
| Sonderfeld S et al. | Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects. | 1985 | Eur. J. Biochem. | pmid:3922757 |
| Raghavan S et al. | GM2-ganglioside metabolism in cultured human skin fibroblasts: unambiguous diagnosis of GM2-gangliosidosis. | 1985 | Biochim. Biophys. Acta | pmid:3995063 |
| Burg J et al. | Mapping of the gene coding for the human GM2 activator protein to chromosome 5. | 1985 | Ann. Hum. Genet. | pmid:3865618 |
| Navon R et al. | Hereditary heat-labile hexosaminidase B: a variant whose homozygotes synthesize a functional HEX A. | 1985 | Am. J. Hum. Genet. | pmid:3156493 |
| Wenger DA | Diagnosis of atypical patients with lipid storage diseases. | 1985 | Brain Dev. | pmid:4014607 |
| Li SC et al. | Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide. | 1985 | J. Biol. Chem. | pmid:2981875 |
| Wood PA et al. | Fluorescence polarization analysis, lipid composition, and Na+, K+-ATPase kinetics of synaptosomal membranes in feline GM1 and GM2 gangliosidosis. | 1985 | J. Neurochem. | pmid:2983023 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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