| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sargeant TJ et al. | Characterization of inducible models of Tay-Sachs and related disease. | 2012 | PLoS Genet. | pmid:23028353 |
| Liu F et al. | Molecular and biochemical characterization of a novel β-N-acetyl-D-hexosaminidase with broad substrate-spectrum from the Aisan corn borer, Ostrinia furnacalis. | 2012 | Int. J. Biol. Sci. | pmid:22991497 |
| Kim CS et al. | Functional interaction analysis of GM1-related carbohydrates and Vibrio cholerae toxins using carbohydrate microarray. | 2012 | Anal. Chem. | pmid:22770420 |
| Saito M et al. | Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain. | 2012 | J. Neurochem. | pmid:22372857 |
| Arthur JR et al. | Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice. | 2012 | Neurochem. Res. | pmid:22367451 |
| Nagahori N et al. | Use of carbohydrate-conjugated nanoparticles for an integrated approach to functional imaging of glycans and understanding of their molecular mechanisms. | 2012 | Curr Pharm Biotechnol | pmid:22039811 |
| Whitehead B et al. | Experiences of dying, death and bereavement in motor neurone disease: a qualitative study. | 2012 | Palliat Med | pmid:21712334 |
| Matsuoka K et al. | Thymic involution and corticosterone level in Sandhoff disease model mice: new aspects the pathogenesis of GM2 gangliosidosis. | 2011 | J. Inherit. Metab. Dis. | pmid:21598013 |
| Kodama T et al. | Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease. | 2011 | PLoS ONE | pmid:22205997 |
| Passos O et al. | QM/MM study of the catalytic mechanism of GalNAc removal from GM2 ganglioside catalyzed by human β-hexosaminidaseA. | 2011 | J Phys Chem B | pmid:22035098 |
| Klisch K et al. | The Sda/GM2-glycan is a carbohydrate marker of porcine primordial germ cells and of a subpopulation of spermatogonia in cattle, pigs, horses and llama. | 2011 | Reproduction | pmid:21896636 |
| Yamada T et al. | Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells. | 2011 | Cancer Sci. | pmid:21895875 |
| Smyth KA et al. | Acquired infantile abducens palsy associated with anti-GM2 antibodies. | 2011 | Pediatr. Neurol. | pmid:21555058 |
| Tetala KK et al. | Selective depletion of neuropathy-related antibodies from human serum by monolithic affinity columns containing ganglioside mimics. | 2011 | J. Med. Chem. | pmid:21488704 |
| Matsuoka K et al. | Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis. | 2011 | Mol. Ther. | pmid:21487393 |
| Fernández-Marrero Y et al. | Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody. | 2011 | Mol. Immunol. | pmid:21306777 |
| Cronin S et al. | Anti-glycolipid GM2-positive Guillain-Barre syndrome due to hepatitis E infection. | 2011 | Ir J Med Sci | pmid:21063804 |
| Hovakimyan M et al. | Morphological alterations of the cornea in the mouse model of niemann-pick disease type c1. | 2011 | Cornea | pmid:21317782 |
| Denny CA et al. | Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. | 2010 | J. Neurochem. | pmid:20374428 |
| Torres PA et al. | Tay-Sachs disease in Jacob sheep. | 2010 | Mol. Genet. Metab. | pmid:20817517 |
| Seyrantepe V et al. | Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. | 2010 | PLoS Genet. | pmid:20862357 |
| Macauley MS et al. | Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. | 2010 | Chem. Biol. | pmid:20851344 |
| Guan F et al. | Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}. | 2010 | FASEB J. | pmid:20720159 |
| Matsuoka K et al. | Introduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease. | 2010 | Mol. Ther. | pmid:20571546 |
| Vitner EB et al. | Common and uncommon pathogenic cascades in lysosomal storage diseases. | 2010 | J. Biol. Chem. | pmid:20430897 |
| Ho CW et al. | Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. | 2010 | ACS Chem. Biol. | pmid:20187655 |
| Batista L et al. | Induced secretion of beta-hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease? | 2010 | Neurobiol. Dis. | pmid:20005954 |
| Tropak MB et al. | A sensitive fluorescence-based assay for monitoring GM2 ganglioside hydrolysis in live patient cells and their lysates. | 2010 | Glycobiology | pmid:19917668 |
| Tomioka R et al. | Neuroblastoma GOTO cells are hypersensitive to disruption of lipid rafts. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19706290 |
| Susuki K et al. | A Guillain-Barré syndrome variant with prominent facial diplegia. | 2009 | J. Neurol. | pmid:19633904 |
| Takimoto K et al. | Storage of gangliosides GM2 and fucosyl GM1 in the kidney of MCC strain of mastomys (Praomys coucha). | 2009 | J. Biochem. | pmid:19556222 |
| Santos GarcÃa D et al. | Multiple cranial neuropathy associated with herpes simplex virus infection and anti-GM2 immunoglobulin M antibodies. | 2009 | J Clin Neuromuscul Dis | pmid:19494732 |
| Guan F et al. | Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19380734 |
| Loly JP et al. | Guillain-Barré syndrome following hepatitis E. | 2009 | World J. Gastroenterol. | pmid:19340910 |
| Kyrkanides S et al. | The trigeminal retrograde transfer pathway in the treatment of neurodegeneration. | 2009 | J. Neuroimmunol. | pmid:19278737 |
| Ortiz N et al. | Effect of anti-GM2 antibodies on rat sciatic nerve: electrophysiological and morphological study. | 2009 | J. Neuroimmunol. | pmid:19232749 |
| Bay S et al. | Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide. | 2009 | ChemMedChem | pmid:19226501 |
| Stubbs KA et al. | A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19130519 |
| Tanabe A et al. | Obesity causes a shift in metabolic flow of gangliosides in adipose tissues. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19116132 |
| Kondo Y et al. | Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. | 2009 | Biochem. Biophys. Res. Commun. | pmid:18996356 |
| Li H et al. | GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice. | 2008 | J. Lipid Res. | pmid:18450647 |
| Kyrkanides S et al. | Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. | 2008 | J. Neuroimmunol. | pmid:18657867 |
| Yoshino H et al. | Identification of gangliosides recognized by IgG anti-GalNAc-GD1a antibodies in bovine spinal motor neurons and motor nerves. | 2008 | Brain Res. | pmid:18598683 |
| Dziadek S et al. | A novel linker methodology for the synthesis of tailored conjugate vaccines composed of complex carbohydrate antigens and specific TH-cell peptide epitopes. | 2008 | Chemistry | pmid:18478617 |
| Sango K et al. | Involvement of retinal neurons and pigment epithelial cells in a murine model of sandhoff disease. | 2008 | Ophthalmic Res. | pmid:18437034 |
| Komori T et al. | Design and efficient synthesis of novel GM2 analogues with respect to the elucidation of the function of GM2 activator. | 2008 | Glycoconj. J. | pmid:18368480 |
| Chen Y et al. | Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. | 2008 | Anal. Chem. | pmid:18314967 |
| Todeschini AR et al. | Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18272501 |
| Seyrantepe V et al. | Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. | 2008 | Hum. Mol. Genet. | pmid:18270209 |
| Boardman AK et al. | Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry. | 2008 | Anal. Chem. | pmid:18717573 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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