| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stencel-Baerenwald J et al. | Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. | 2015 | MBio | pmid:25736887 |
| Livingston PO et al. | Characterization of IgG and IgM antibodies induced in melanoma patients by immunization with purified GM2 ganglioside. | 1989 | Cancer Res. | pmid:2582446 |
| Baba H et al. | Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. | 1989 | J. Neuroimmunol. | pmid:2584393 |
| Rockwell HE et al. | AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. | ASN Neuro | pmid:25873306 | |
| Zvezdina ND et al. | Gangliosides of sea urchin embryos. Their localization and participation in early development. | 1989 | Eur. J. Biochem. | pmid:2598928 |
| Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
| Anheuser S et al. | Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. | 2015 | J. Lipid Res. | pmid:26175473 |
| Mahata B et al. | GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway. | 2015 | PLoS ONE | pmid:26226135 |
| Sikora J et al. | X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities. | 2016 | Dis Model Mech | pmid:26515654 |
| Yin Z et al. | Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies. | 2016 | Chembiochem | pmid:26538065 |
| Spagnoli C et al. | CMV-associated axonal sensory-motor Guillain-Barré syndrome in a child: Case report and review of the literature. | 2016 | Eur. J. Paediatr. Neurol. | pmid:26621312 |
| Dotta F et al. | Ganglioside expression in human pancreatic islets. | 1989 | Diabetes | pmid:2695376 |
| Kohyama M et al. | In situ detection of GM1 and GM2 gangliosides using immunohistochemical and immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses. | 2016 | BMC Vet. Res. | pmid:27036194 |
| Kundu M et al. | Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. | 2016 | Biochim. Biophys. Acta | pmid:27066976 |
| Worstell NC et al. | Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array. | 2016 | PLoS ONE | pmid:27070150 |
| Riboni L et al. | Formation of ganglioside GD1b-lactone in rat brain from intracisternally administered GD1b. | 1989 | J. Neurochem. | pmid:2709011 |
| Hoon DS et al. | Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells. | 1989 | Int. J. Cancer | pmid:2714890 |
| Karumuthil-Melethil S et al. | Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease. | 2016 | Hum. Gene Ther. | pmid:27197548 |
| Tanaka K et al. | Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines. | 2016 | Glycoconj. J. | pmid:27270764 |
| Ishigaki H et al. | Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AÂ Case Report and Review of the Literature. | 2016 | Pediatr. Neurol. | pmid:27400822 |
| Jones PC and Irie RF | Therapeutic Strategies for Human IgM Antibodies Directed at Tumor-Associated Ganglioside Antigens: Discoveries Made During the Morton Era and Future Directions. | 2016 | Crit Rev Oncog | pmid:27481004 |
| Wolf H et al. | A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. | 2016 | Dis Model Mech | pmid:27491075 |
| Schröder M et al. | Isolation of a cDNA encoding the human GM2 activator protein. | 1989 | FEBS Lett. | pmid:2753159 |
| Dufresne M et al. | Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry. | 2017 | Anal Bioanal Chem | pmid:27873002 |
| Trilck M et al. | Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. | 2017 | Brain Res. | pmid:27923633 |
| Ghidoni R et al. | Metabolism of exogenous gangliosides in cerebellar granule cells, differentiated in culture. | 1989 | J. Neurochem. | pmid:2795018 |
| Cavaillon JM et al. | Ganglioside identification on human monocyte membrane with Clostridium perfringens delta-toxin. | 1986 | J. Leukoc. Biol. | pmid:2872258 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Komura N et al. | Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. | 2017 | Meth. Enzymol. | pmid:28935104 |
| Raghavan SS et al. | GM2-ganglioside metabolism in hexosaminidase A deficiency states: determination in situ using labeled GM2 added to fibroblast cultures. | 1985 | Am. J. Hum. Genet. | pmid:2934978 |
| Charrow J and Binns HJ | Ganglioside loading of cultured fibroblasts: a provocative method for the diagnosis of the GM2 gangliosidoses. | 1986 | Clin. Chim. Acta | pmid:2938852 |
| Ishikawa Y et al. | Biochemical basis of type AB GM2 gangliosidosis in a Japanese spaniel. | 1987 | J. Neurochem. | pmid:2949061 |
| Harding AE et al. | Adult onset supranuclear ophthalmoplegia, cerebellar ataxia, and neurogenic proximal muscle weakness in a brother and sister: another hexosaminidase A deficiency syndrome. | 1987 | J. Neurol. Neurosurg. Psychiatry | pmid:2956362 |
| Eto Y et al. | Partial deficiency of beta-hexosaminidase activity in canine GM2-gangliosidosis. | 1987 | Tohoku J. Exp. Med. | pmid:2958961 |
| DeGasperi R et al. | A GM2-specific beta-hexosaminidase from the roe of striped mullet (Mugil cephalus). | 1988 | J. Biol. Chem. | pmid:2961751 |
| Ohno K and Suzuki K | Mutation in GM2-gangliosidosis B1 variant. | 1988 | J. Neurochem. | pmid:2961848 |
| Budde-Steffen C et al. | Presence of beta-hexosaminidase A alpha-chain mRNA in two different variants of GM2-gangliosidosis. | 1988 | Neuropediatrics | pmid:2967444 |
| Tanaka A et al. | GM2-gangliosidosis B1 variant: a wide geographic and ethnic distribution of the specific beta-hexosaminidase alpha chain mutation originally identified in a Puerto Rican patient. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2973311 |
| Lichtenberg P et al. | Post-partum psychosis in adult GM2 gangliosidosis. A case report. | 1988 | Br J Psychiatry | pmid:2977954 |
| Li SC et al. | Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide. | 1985 | J. Biol. Chem. | pmid:2981875 |
| Wood PA et al. | Fluorescence polarization analysis, lipid composition, and Na+, K+-ATPase kinetics of synaptosomal membranes in feline GM1 and GM2 gangliosidosis. | 1985 | J. Neurochem. | pmid:2983023 |
| Berry-Kravis E and Dawson G | Possible role of gangliosides in regulating an adenylate cyclase-linked 5-hydroxytryptamine (5-HT1) receptor. | 1985 | J. Neurochem. | pmid:2997394 |
| Kotagal S | Diagnosis of AB variant, GM2 gangliosidosis. | 1986 | Ann. Neurol. | pmid:3080943 |
| Oates CE et al. | Movement disorders associated with chronic GM2 gangliosidosis. Case report and review of the literature. | 1986 | Eur. Neurol. | pmid:3081350 |
| Kotagal S et al. | AB variant GM2 gangliosidosis: cerebrospinal fluid and neuropathologic characteristics. | 1986 | Neurology | pmid:3081832 |
| Zeigler M and Bach G | Internalization of exogenous gangliosides in cultured skin fibroblasts for the diagnosis of mucolipidosis IV. | 1986 | Clin. Chim. Acta | pmid:3087662 |
| Yanagisawa K et al. | Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver. | 1987 | Biochim. Biophys. Acta | pmid:3109491 |
| Nagai K and Ishizuka I | Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain. | 1987 | J. Biochem. | pmid:3115968 |
| Naoi M et al. | Ganglioside GM1 causes expression of type B monoamine oxidase in a rat clonal pheochromocytoma cell line, PC12h. | 1987 | J. Neurochem. | pmid:3117976 |
| Naoi M et al. | Specific binding of glycosylated beta-galactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides. | 1988 | J. Neurochem. | pmid:3126266 |
| Kushi Y et al. | Direct analysis of glycolipids on thin-layer plates by matrix-assisted secondary ion mass spectrometry: application for glycolipid storage disorders. | 1988 | Anal. Biochem. | pmid:3149874 |
| Navon R et al. | Hereditary heat-labile hexosaminidase B: a variant whose homozygotes synthesize a functional HEX A. | 1985 | Am. J. Hum. Genet. | pmid:3156493 |
| Kytzia HJ and Sandhoff K | Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A. | 1985 | J. Biol. Chem. | pmid:3158659 |
| Jolivet-Reynaud C et al. | Damaging effects of Clostridium perfringens delta toxin on blood platelets and their relevance to ganglioside GM2. | 1988 | Arch. Biochem. Biophys. | pmid:3162668 |
| Miyake M et al. | Generation of two murine monoclonal antibodies that can discriminate N-glycolyl and N-acetyl neuraminic acid residues of GM2 gangliosides. | 1988 | Cancer Res. | pmid:3167861 |
| Yamanaka T et al. | Detection of gangliotriaose-series glycosphingolipids in serum of cord blood and patients with neuroblastoma by a sensitive TLC/enzyme-immunostaining method. | 1987 | Biochim. Biophys. Acta | pmid:3300782 |
| Geiger B and Smolarsky M | Immunochemical determination of ganglioside GM2, by inhibition of complement-dependent liposome lysis. | 1977 | J. Immunol. Methods | pmid:333030 |
| Torres BV et al. | Glycolipid-lectin interactions: reactivity of lectins from Helix pomatia, Wisteria floribunda, and Dolichos biflorus with glycolipids containing N-acetylgalactosamine. | 1988 | Arch. Biochem. Biophys. | pmid:3355161 |
| Livingston PO et al. | Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3472242 |
| Dawson G et al. | Regulation of GM2 ganglioside metabolism in cultured cells. | 1986 | Chem. Phys. Lipids | pmid:3549015 |
| Ando I et al. | Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells. | 1987 | Int. J. Cancer | pmid:3596830 |
| Rosengren B et al. | Composition of gangliosides and neutral glycosphingolipids of brain in classical Tay-Sachs and Sandhoff disease: more lyso-GM2 in Sandhoff disease? | 1987 | J. Neurochem. | pmid:3612128 |
| Wynn CH and Robson B | Calculation of the conformation of glycosphingolipids. 2. GM1- and GM2-gangliosides. | 1986 | J. Theor. Biol. | pmid:3626589 |
| Li YT et al. | Occurrence of ceramide-glycanase in the earthworm, Lumbricus terrestris. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3689409 |
| Natoli EJ et al. | A murine monoclonal antibody detecting N-acetyl- and N-glycolyl-GM2: characterization of cell surface reactivity. | 1986 | Cancer Res. | pmid:3731079 |
| Miyagi T and Tsuiki S | Evidence for sialidase hydrolyzing gangliosides GM2 and GM1 in rat liver plasma membrane. | 1986 | FEBS Lett. | pmid:3758350 |
| Livingston PO et al. | Approaches to augmenting the immunogenicity of the ganglioside GM2 in mice: purified GM2 is superior to whole cells. | 1987 | J. Immunol. | pmid:3805726 |
| Sugimoto M et al. | Total synthesis of gangliosides GM1 and GM2. | 1986 | Carbohydr. Res. | pmid:3815403 |
| Burg J et al. | Mapping of the gene coding for the human GM2 activator protein to chromosome 5. | 1985 | Ann. Hum. Genet. | pmid:3865618 |
| Higashi H et al. | Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer. | 1985 | Cancer Res. | pmid:3874688 |
| Sonderfeld S et al. | Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects. | 1985 | Eur. J. Biochem. | pmid:3922757 |
| Kasai N et al. | Preparation and specificity of avian anti-GM2(NeuGc) ganglioside antiserum. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3925943 |
| Ishizuka I et al. | Preparation and enzymatic degradation of monosulfogangliotriaosylceramide. | 1985 | J. Biol. Chem. | pmid:3928630 |
| Dahiya R and Brasitus TA | Glycosphingolipid patterns of fetal and adult small intestinal mucosa in the sheep. | 1986 | Biochim. Biophys. Acta | pmid:3942764 |
| Raghavan S et al. | GM2-ganglioside metabolism in cultured human skin fibroblasts: unambiguous diagnosis of GM2-gangliosidosis. | 1985 | Biochim. Biophys. Acta | pmid:3995063 |
| Iwamori M et al. | Brain gangliosides of quaking and shiverer mutants: qualitative and quantitative changes of monosialogangliosides in the quaking brain. | 1985 | J. Neurochem. | pmid:3998734 |
| Wenger DA | Diagnosis of atypical patients with lipid storage diseases. | 1985 | Brain Dev. | pmid:4014607 |
| Cork LC et al. | GM2 ganglioside lysosomal storage disease in cats with beta-hexosaminidase deficiency. | 1977 | Science | pmid:404709 |
| Duffard RO et al. | Ganglioside composition and biosynthesis in cultred cells derived from CNS. | 1977 | J. Neurochem. | pmid:406360 |
| Sasaki T | Glycolipid-binding proteins. | 1985 | Chem. Phys. Lipids | pmid:4064224 |
| Bernheimer H et al. | Sandhoff disease: ganglioside G(M2) and asialo-G(M2) accumulation in the cerebrospinal fluid. | 1977 | J. Neurochem. | pmid:407331 |
| Novak A et al. | Preparation of radiolabeled GM2 and GA2 gangliosides. | 1979 | J. Lipid Res. | pmid:490046 |
| O'Brien JS and Geiger B | Normal adult with absent HEX A: immunoreactive HEX A is present. | 1979 | Am. J. Hum. Genet. | pmid:507054 |
| Young WW et al. | Production of monoclonal antibodies specific for two distinct steric portions of the glycolipid ganglio-N-triosylceramide (asialo GM2). | 1979 | J. Exp. Med. | pmid:512581 |
| O'Neill B et al. | Adult-onset GM2 gangliosidosis. Seizures, dementia, and normal pressure hydrocephalus associated with glycolipid storage in the brain and arachnoid granulation. | 1978 | Neurology | pmid:568730 |
| Hechtman P and LeBlanc D | Purification and properties of the hexosaminidase A-activating protein from human liver. | 1977 | Biochem. J. | pmid:603630 |
| Boggs JM et al. | Immune lysis of lipid vesicles containing myelin basic protein or glycolipid antigens by multiple sclerosis and normal sera. | J. Neurol. Sci. | pmid:6085112 | |
| Itoh H et al. | The fine structure of cytoplasmic inclusions in brain and other visceral organs in Sandhoff disease. | 1984 | Brain Dev. | pmid:6097133 |
| Schwab ME and Vassella F | Synopsis: gangliosidoses. | 1984 | Neuropediatrics | pmid:6100793 |
| Schulte FJ | Clinical course of GM2 gangliosidoses. A correlative attempt. | 1984 | Neuropediatrics | pmid:6100797 |
| Pampiglione G and Harden A | Neurophysiological investigations in GM1 and GM2 gangliosidoses. | 1984 | Neuropediatrics | pmid:6100798 |
| Di Gregorio F et al. | The influence of gangliosides on neurite growth and regeneration. | 1984 | Neuropediatrics | pmid:6100799 |
| Goebel HH | Morphology of the gangliosidoses. | 1984 | Neuropediatrics | pmid:6100800 |
| Tai T et al. | Ganglioside GM2 as a human tumor antigen (OFA-I-1). | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6193515 |
| Poulos A et al. | Diagnosis of Tay-Sachs disease using [3H]N-acetylneuraminic acid labelled GM2 ganglioside as substrate. | 1982 | Clin. Chim. Acta | pmid:6210469 |
| Conzelmann E et al. | Complexing of glycolipids and their transfer between membranes by the activator protein for degradation of lysosomal ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6210531 |
| Hasilik A et al. | Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6214395 |
| Schwerer B et al. | Antisera against ganglioside GM2: immunochemical and immunohistological studies. | Neuropathol. Appl. Neurobiol. | pmid:6214725 | |
| Li YT et al. | Differentiation of two variants of type-AB GM2-gangliosidosis using chromogenic substrates. | 1983 | Am. J. Hum. Genet. | pmid:6222647 |
| Inui K et al. | Juvenile GM2 gangliosidosis (AMB variant): inability to activate hexosaminidase A by activator protein. | 1983 | Am. J. Hum. Genet. | pmid:6224417 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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