| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sato M et al. | Accumulation of cholesterol and GM2 ganglioside in cells cultured in the presence of progesterone: an implication for the basic defect in Niemann-Pick disease type C. | 1998 | Brain Dev. | pmid:9533562 |
| Watanabe Y et al. | Increased levels of GM2 ganglioside in fibroblasts from a patient with juvenile Niemann-Pick disease type C. | 1998 | Brain Dev. | pmid:9545179 |
| Bitzan MM et al. | Inhibition of Helicobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. | 1998 | J. Infect. Dis. | pmid:9534968 |
| Xie B et al. | Biochemical characterization of the Cys138Arg substitution associated with the AB variant form of GM2 gangliosidosis: evidence that Cys138 is required for the recognition of the GM2 activator/GM2 ganglioside complex by beta-hexosaminidase A. | 1998 | Biochemistry | pmid:9454570 |
| Yuziuk JA et al. | Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2. | 1998 | J. Biol. Chem. | pmid:9417048 |
| Dotta F et al. | The GM2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is not beta-cell specific. | 1998 | Endocrinology | pmid:9421429 |
| Cavanna B et al. | Anti-GM2 IgM antibodies: clinical correlates and reactivity with a human neuroblastoma cell line. | 1999 | J. Neuroimmunol. | pmid:10376949 |
| Kolter T et al. | Recent advances in the biochemistry of glycosphingolipid metabolism. | 1999 | Biochem. Soc. Trans. | pmid:10917612 |
| Mahuran DJ | Biochemical consequences of mutations causing the GM2 gangliosidoses. | 1999 | Biochim. Biophys. Acta | pmid:10571007 |
| Nakamura K et al. | Apoptosis induction of human lung cancer cell line in multicellular heterospheroids with humanized antiganglioside GM2 monoclonal antibody. | 1999 | Cancer Res. | pmid:10537316 |
| Zuberbier T et al. | Alterations in ganglioside expression during the differentiation of human mast cells. | 1999 | Exp. Dermatol. | pmid:10536964 |
| Okada N et al. | Human IgM monoclonal antibody to ganglioside GM2 and complement suppress virus propagation in ex vivo cultures of lymphocytes from HIV-1 infected patients. | 1999 | Microbiol. Immunol. | pmid:10529115 |
| Okada N and Okada H | Human IgM antibody therapy for HIV-1 infection. | 1999 | Microbiol. Immunol. | pmid:10524789 |
| Sorice M et al. | Glycosphingolipid domains on cell plasma membrane. | 1999 | Biosci. Rep. | pmid:10513897 |
| Zervas M and Walkley SU | Ferret pyramidal cell dendritogenesis: changes in morphology and ganglioside expression during cortical development. | 1999 | J. Comp. Neurol. | pmid:10502250 |
| Gori AH et al. | Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. | 1999 | Am. J. Trop. Med. Hyg. | pmid:10497993 |
| Macias A et al. | Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg). | 1999 | Hybridoma | pmid:10475241 |
| Ecsedy JA et al. | Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice. | 1999 | J. Neurochem. | pmid:10386978 |
| Raghavan S et al. | G(M2)-ganglioside metabolism in situ in mucolipidosis IV fibroblasts. | 1999 | Neurochem. Res. | pmid:10227679 |
| Mizutani K et al. | Enhancement of TNF-alpha production by ganglioside GM2 in human mononuclear cell culture. | 1999 | Neuroreport | pmid:10208534 |
| Li YT et al. | Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation. | 1999 | J. Biol. Chem. | pmid:10187778 |
| Khalili-Shirazi A et al. | Antiganglioside antibodies in Guillain-Barré syndrome after a recent cytomegalovirus infection. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10084538 |
| Mundel TM et al. | Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells. | 1999 | J. Am. Soc. Nephrol. | pmid:10073593 |
| Takahashi T et al. | IgM anti-ganglioside antibodies induced by melanoma cell vaccine correlate with survival of melanoma patients. | 1999 | J. Invest. Dermatol. | pmid:9989797 |
| Usuki S et al. | GM2 promotes ciliary neurotrophic factor-dependent rescue of immortalized motor neuron-like cell (NSC-34). | 1999 | Neurochem. Res. | pmid:9972876 |
| Sakuraba H et al. | GM2 gangliosidosis AB variant: clinical and biochemical studies of a Japanese patient. | 1999 | Neurology | pmid:9932959 |
| Wu X et al. | Complement-mediated anti-HIV-1 effect induced by human IgM monoclonal antibody against ganglioside GM2. | 1999 | J. Immunol. | pmid:9886430 |
| Fukumoto H et al. | Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo. | 1999 | Int. J. Cancer | pmid:10417777 |
| Slevin M et al. | Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. | 1999 | Int. J. Cancer | pmid:10399959 |
| Hanibuchi M et al. | Immunological circumvention of multiple organ metastases of multidrug resistant human small cell lung cancer cells by mouse-human chimeric anti-ganglioside GM2 antibody KM966. | 2000 | Clin. Exp. Metastasis | pmid:11467766 |
| Hedberg KM et al. | Monoclonal anti-GD3 antibodies selectively inhibit the proliferation of human malignant glioma cells in vitro. | 2000 | Glycoconj. J. | pmid:11425192 |
| Nakamura K et al. | Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody. | 2000 | Mol. Immunol. | pmid:11399321 |
| Chapman PB et al. | Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine: a trial comparing doses of G(D2)-keyhole limpet hemocyanin. | 2000 | Clin. Cancer Res. | pmid:11156217 |
| Chiavegatto S et al. | A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice. | 2000 | Exp. Neurol. | pmid:11085888 |
| Portoukalian J | Immunogenicity of glycolipids. | 2000 | Clin Rev Allergy Immunol | pmid:11064828 |
| Wu X et al. | The IgM antibody level against ganglioside GM2 correlates to the disease status of HIV-1-infected patients. | 2000 | Microbiol. Immunol. | pmid:10888361 |
| Tsurifune T et al. | Alteration of tumor phenotypes of B16 melanoma after genetic remodeling of the ganglioside profile. | 2000 | Int. J. Oncol. | pmid:10853034 |
| Chapman PB et al. | Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: a dose-response study. | 2000 | Clin. Cancer Res. | pmid:10741710 |
| Ang CW et al. | Campylobacter jejuni lipopolysaccharides from Guillain-Barré syndrome patients induce IgG anti-GM1 antibodies in rabbits. | 2000 | J. Neuroimmunol. | pmid:10713352 |
| Brezicka T et al. | Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues. | 2000 | Lung Cancer | pmid:10704706 |
| Pospisil M et al. | Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1. | 2000 | Int. J. Oncol. | pmid:10639569 |
| Bierfreund U et al. | Sphingolipid hydrolases and activator proteins. | 2000 | Meth. Enzymol. | pmid:10563332 |
| Ang CW et al. | Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barré syndrome. | 2000 | Neurology | pmid:10751257 |
| Taniguchi M et al. | Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain. | 2001 | Brain Dev. | pmid:11578853 |
| Teixeira CA et al. | Retrovirus-mediated transfer and expression of beta-hexosaminidase alpha-chain cDNA in human fibroblasts from G(M2)-gangliosidosis B1 variant. | 2001 | Hum. Gene Ther. | pmid:11560770 |
| Beccari T et al. | Promoter characterization and expression of the gene coding for the human GM2 activator protein. | 2001 | Biosci. Rep. | pmid:11508694 |
| Saito M and Sugiyama K | Gangliosides in rat kidney: composition, distribution, and developmental changes. | 2001 | Arch. Biochem. Biophys. | pmid:11360994 |
| Kirkwood JM et al. | High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. | 2001 | J. Clin. Oncol. | pmid:11331315 |
| Werth N et al. | Degradation of membrane-bound ganglioside GM2 by beta -hexosaminidase A. Stimulation by GM2 activator protein and lysosomal lipids. | 2001 | J. Biol. Chem. | pmid:11278374 |
| Parajuli P et al. | Humanized anti-ganglioside GM2 antibody is effective to induce antibody-dependent cell-mediated cytotoxicity in mononuclear cells from lung cancer patients. | 2001 | Cancer Lett. | pmid:11275367 |
| Kirkwood JM et al. | High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: results of the Multicenter Eastern Cooperative Oncology Group Phase II Trial E2696. | 2001 | J. Clin. Oncol. | pmid:11230488 |
| Kaida K et al. | Guillain-Barré syndrome with IgM antibody to the ganglioside GalNAc-GD1a. | 2001 | J. Neuroimmunol. | pmid:11164910 |
| Mattson MP | New blood cells help an overburdened brain. | 2001 | Trends Neurosci. | pmid:11163874 |
| Sueyoshi N et al. | Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations. | 2001 | J. Lipid Res. | pmid:11483620 |
| Ortiz N et al. | IgM monoclonal antibody against terminal moiety of GM2, GalNAc-GD1a and GalNAc-GM1b from a pure motor chronic demyelinating polyneuropathy patient: effects on neurotransmitter release. | 2001 | J. Neuroimmunol. | pmid:11525808 |
| Cavanna B et al. | Anti-GM(2) IgM antibody-induced complement-mediated cytotoxicity in patients with dysimmune neuropathies. | 2001 | J. Neuroimmunol. | pmid:11240036 |
| Gouni-Berthold I et al. | Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. | 2001 | Hypertension | pmid:11711493 |
| Li SC et al. | Degradation of G(M1) and G(M2) by mammalian sialidases. | 2001 | Biochem. J. | pmid:11696012 |
| Yoshida S et al. | Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. | 2001 | Cancer Res. | pmid:11358851 |
| Ang CW et al. | Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits. | 2001 | Infect. Immun. | pmid:11254608 |
| Zervas M et al. | Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations. | 2001 | J. Neuropathol. Exp. Neurol. | pmid:11202175 |
| Wölfl M et al. | Gangliosides inhibit the development from monocytes to dendritic cells. | 2002 | Clin. Exp. Immunol. | pmid:12452834 |
| Martino S et al. | Restoration of the GM2 ganglioside metabolism in bone marrow-derived stromal cells from Tay-Sachs disease animal model. | 2002 | Neurochem. Res. | pmid:12374215 |
| Ravasi D et al. | Study of interaction of GM2 activator protein with GM2 using circular dichroism and fluorescence spectroscopy. | 2002 | Neurochem. Res. | pmid:12374214 |
| Jeyakumar M et al. | Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis. | 2002 | Neuropathol. Appl. Neurobiol. | pmid:12366816 |
| Jeyakumar M et al. | An inducible mouse model of late onset Tay-Sachs disease. | 2002 | Neurobiol. Dis. | pmid:12270683 |
| Niazi KR et al. | The CD1b structure: antigen presentation adapts to a high-fat diet. | 2002 | Nat. Immunol. | pmid:12145652 |
| Gadola SD et al. | Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. | 2002 | Nat. Immunol. | pmid:12118248 |
| Lopate G et al. | Severe sensory ataxia and demyelinating polyneuropathy with IgM anti-GM2 and GalNAc-GD1A antibodies. | 2002 | Muscle Nerve | pmid:12115971 |
| Myerowitz R et al. | Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling. | 2002 | Hum. Mol. Genet. | pmid:12019216 |
| Alaedini A et al. | Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay. | 2002 | J. Neurol. Sci. | pmid:11959155 |
| Martino S et al. | Absence of metabolic cross-correction in Tay-Sachs cells: implications for gene therapy. | 2002 | J. Biol. Chem. | pmid:11923278 |
| Sango K et al. | Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease. | 2002 | Neuropathol. Appl. Neurobiol. | pmid:11849560 |
| Mehta RR et al. | In vitro transformation of human congenital naevus to malignant melanoma. | 2002 | Melanoma Res. | pmid:11828255 |
| Guerry P et al. | Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro. | 2002 | Infect. Immun. | pmid:11796612 |
| Miljan EA et al. | Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides. | 2002 | J. Biol. Chem. | pmid:11796728 |
| Trindade VM et al. | Ganglioside alterations in the central nervous system of rats chronically injected with methylmalonic and propionic acids. | 2002 | Metab Brain Dis | pmid:12083341 |
| Wendeler M et al. | Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay. | 2003 | Meth. Enzymol. | pmid:14579597 |
| Li YT et al. | Structural basis for the enzymatic resistance of the GM2 ganglioside. | 2003 | Meth. Enzymol. | pmid:14579580 |
| Mauri L et al. | Procedure for separation of GM2 ganglioside species with different ceramide structures by a flash reversed-phase silica gel liquid chromatography. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14552811 |
| Brown ER and Ibrahim JG | A Bayesian semiparametric joint hierarchical model for longitudinal and survival data. | 2003 | Biometrics | pmid:12926706 |
| Li YT et al. | Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. | 2003 | J. Biol. Chem. | pmid:12829702 |
| Antoine T et al. | Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli. | 2003 | Chembiochem | pmid:12740812 |
| Mizutani K et al. | Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2. | 2003 | Intern. Med. | pmid:12705795 |
| Odaka M and Yuki N | Antibodies to GM2 ganglioside in neurological disorders. | 2003 | Intern. Med. | pmid:12705785 |
| Yamaguchi A et al. | Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease. | 2003 | J. Mol. Med. | pmid:12682727 |
| Rapoport E et al. | Ganglioside binding pattern of CD33-related siglecs. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639556 |
| Shimada Y et al. | Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin. | 2003 | J. Lipid Res. | pmid:12576516 |
| Chen HH et al. | Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene. | 2003 | Int. J. Cancer | pmid:12455030 |
| Sharma R et al. | A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside. | 2003 | Biochim. Biophys. Acta | pmid:12527415 |
| Irie S et al. | Detection of serum anti-ganglioside antibodies by latex agglutination assay in Guillain-Barré syndrome: comparison with ELISA. | 2003 | Intern. Med. | pmid:12857046 |
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| Yamato O et al. | GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family of Japanese domestic cats. | 2004 | Vet. Rec. | pmid:15623087 |
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Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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