| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuki N et al. | Antibody to GalNAc-GD1a and GalNAc-GM1b in Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis. | 1996 | J. Neuroimmunol. | pmid:8982115 |
| Nishinaka Y et al. | Development of a human monoclonal antibody to ganglioside G(M2) with potential for cancer treatment. | 1996 | Cancer Res. | pmid:8971173 |
| Takamiya K et al. | Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8855236 |
| Dotta F et al. | Autoimmunity to the GM2-1 islet ganglioside before and at the onset of type I diabetes. | 1996 | Diabetes | pmid:8772721 |
| Tse R et al. | Identification of functional domains within the alpha and beta subunits of beta-hexosaminidase A through the expression of alpha-beta fusion proteins. | 1996 | Biochemistry | pmid:8718882 |
| De Gasperi R et al. | Late-onset GM2 gangliosidosis: Ashkenazi Jewish family with an exon 5 mutation (Tyr180-->His) in the Hex A alpha-chain gene. | 1996 | Neurology | pmid:8757036 |
| Pennybacker M et al. | Identification of domains in human beta-hexosaminidase that determine substrate specificity. | 1996 | J. Biol. Chem. | pmid:8663217 |
| Tse R et al. | Identification of an active acidic residue in the catalytic site of beta-hexosaminidase. | 1996 | Biochemistry | pmid:8652542 |
| Kimata H and Yoshida A | Inhibition of spontaneous immunoglobulin production by ganglioside GM2 in human B cells. | 1996 | Clin. Immunol. Immunopathol. | pmid:8620627 |
| Ritter G et al. | Induction of antibodies reactive with GM2 ganglioside after immunization with lipopolysaccharides from Camplyobacter jejuni. | 1996 | Int. J. Cancer | pmid:8603809 |
| Hou Y et al. | Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A. | 1996 | Biochemistry | pmid:8672428 |
| Ribeiro MG et al. | Clinical, enzymatic, and molecular characterisation of a Portuguese family with a chronic form of GM2-gangliosidosis B1 variant. | 1996 | J. Med. Genet. | pmid:8730294 |
| Fukumoto H et al. | Reversal of adriamycin resistance with chimeric anti-ganglioside GM2 antibody. | 1996 | Int. J. Cancer | pmid:8782657 |
| Kimata H | Differential effects of gangliosides on human IgE and IgG4 production. | 1995 | Eur. J. Immunol. | pmid:7843249 |
| Yuki N et al. | Ganglioside-like epitopes of lipopolysaccharides from Campylobacter jejuni (PEN 19) in three isolates from patients with Guillain-Barré syndrome. | 1995 | J. Neurol. Sci. | pmid:7544402 |
| Nakamura M et al. | Biosynthesis of the so-called "a" and "asialo" pathway glycosphingolipids is differentially regulated in murine myelogenous leukemia NFS60 cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:8554592 |
| Haraguchi M et al. | The effects of the site-directed removal of N-glycosylation sites from beta-1,4-N-acetylgalactosaminyltransferase on its function. | 1995 | Biochem. J. | pmid:7492324 |
| Ruan S et al. | Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression. | 1995 | Arch. Biochem. Biophys. | pmid:7487055 |
| Li SC et al. | Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein. | 1995 | J. Biol. Chem. | pmid:7592631 |
| Liessem B et al. | Photoaffinity labeling of human lysosomal beta-hexosaminidase B. Identification of Glu-355 at the substrate binding site. | 1995 | J. Biol. Chem. | pmid:7559539 |
| Walkley SU | Pyramidal neurons with ectopic dendrites in storage diseases exhibit increased GM2 ganglioside immunoreactivity. | 1995 | Neuroscience | pmid:8544979 |
| Matsumoto A et al. | Ganglioside characterization of a cell line displaying motor neuron-like phenotype: GM2 as a possible major ganglioside in motor neurons. | 1995 | J. Neurol. Sci. | pmid:7595635 |
| Nakayama J et al. | Differential cell- and immuno-biological properties of murine B16-F1 and F10 melanomas: oncogene c-fos expression, sensitivity to LAK cells and/or IL-2, and components of gangliosides. | 1995 | J. Dermatol. | pmid:7560451 |
| Kuroki Y et al. | A novel missense mutation (C522Y) is present in the beta-hexosaminidase beta-subunit gene of a Japanese patient with infantile Sandhoff disease. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626071 |
| Helling F et al. | GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21. | 1995 | Cancer Res. | pmid:7796403 |
| Lemos M et al. | Prenatal diagnosis of GM2-gangliosidosis B1 variant. | 1995 | Prenat. Diagn. | pmid:7659693 |
| Alfonso M et al. | T cell-independent B cell response to self-monosialogangliosides: primary response monoclonal antibodies. | 1995 | Hybridoma | pmid:7590782 |
| Taga S et al. | Differential regulation of glycosphingolipid biosynthesis in phenotypically distinct Burkitt's lymphoma cell lines. | 1995 | Int. J. Cancer | pmid:7705957 |
| Zebda N et al. | Deficiency of ganglioside biosynthesis in metastatic human melanoma cells: relevance of CMP-NeuAc:LacCer alpha 2-3 sialyltransferase (GM3 synthase). | 1995 | FEBS Lett. | pmid:7720864 |
| Kitamura K et al. | Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7708728 |
| Yuyama Y et al. | Enhanced expression of GM2/GD2 synthase mRNA in human gastrointestinal cancer. | 1995 | Cancer | pmid:7533654 |
| Taga S et al. | Sequential changes in glycolipid expression during human B cell differentiation: enzymatic bases. | 1995 | Biochim. Biophys. Acta | pmid:7811747 |
| Riboni L et al. | The degradative pathway of gangliosides GM1 and GM2 in Neuro2a cells by sialidase. | 1995 | J. Neurochem. | pmid:7798945 |
| Heffer-Lauc M et al. | Glycoprotein and ganglioside changes in human trophoblasts after exposure to pulsed Doppler ultrasound. | 1995 | Ultrasound Med Biol | pmid:7571151 |
| Mizutamari RK et al. | Characterization of anti-ganglioside antibodies present in normal human plasma. | 1994 | J. Neuroimmunol. | pmid:8120143 |
| Shitara K et al. | Immunoglobulin class switch of anti-ganglioside monoclonal antibody from IgM to IgG. | 1994 | J. Immunol. Methods | pmid:8133075 |
| Wu YY et al. | Expression and specificity of human GM2 activator protein. | 1994 | J. Biol. Chem. | pmid:8206933 |
| Novak A et al. | Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate. | 1994 | Biochim. Biophys. Acta | pmid:8123671 |
| Yamanaka S et al. | The mouse gene encoding the GM2 activator protein (Gm2a): cDNA sequence, expression, and chromosome mapping. | 1994 | Genomics | pmid:7713516 |
| Lutz MS et al. | Cloned beta 1,4 N-acetylgalactosaminyltransferase synthesizes GA2 as well as gangliosides GM2 and GD2. GM3 synthesis has priority over GA2 synthesis for utilization of lactosylceramide substrate in vivo. | 1994 | J. Biol. Chem. | pmid:7961890 |
| Hidari JK et al. | beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F. | 1994 | Biochem. J. | pmid:7980468 |
| Yoshimura A et al. | GD2 ganglioside-specific monoclonal antibody reacts with murine cytotoxic T lymphocytes reactive with FBL-3N erythroleukaemia. | 1994 | Scand. J. Immunol. | pmid:7973461 |
| Beccari T et al. | GM2 activator protein expression in mouse tissues. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7980537 |
| Fujita S et al. | Total synthesis of a modified ganglioside, de-N-acetyl GM2. | 1994 | Carbohydr. Res. | pmid:7805050 |
| Rapola J | Lysosomal storage diseases in adults. | 1994 | Pathol. Res. Pract. | pmid:7831151 |
| Livingston PO et al. | Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside. | 1994 | J. Clin. Oncol. | pmid:8164027 |
| Siegel DA and Walkley SU | Growth of ectopic dendrites on cortical pyramidal neurons in neuronal storage diseases correlates with abnormal accumulation of GM2 ganglioside. | 1994 | J. Neurochem. | pmid:8158134 |
| Kotani M et al. | Evidence for direct binding of intracellularly distributed ganglioside GM2 to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts. | 1994 | Cell Struct. Funct. | pmid:7923401 |
| Nakamura K et al. | Chimeric anti-ganglioside GM2 antibody with antitumor activity. | 1994 | Cancer Res. | pmid:8137257 |
| Novak A and Lowden JA | GM2 ganglioside activator occurs in multiple forms. | 1994 | Biochim. Biophys. Acta | pmid:8123670 |
| Rolsma MD et al. | Assay for evaluation of rotavirus-cell interactions: identification of an enterocyte ganglioside fraction that mediates group A porcine rotavirus recognition. | 1994 | J. Virol. | pmid:8254737 |
| Cotterchio M and Seyfried TN | Serum gangliosides in mice with metastatic and non-metastatic brain tumors. | 1994 | J. Lipid Res. | pmid:8138710 |
| Zeballos RS et al. | Anti-glycosphingolipid autoantibodies in rheumatologic disorders. | 1994 | J. Clin. Lab. Anal. | pmid:7869176 |
| Nakao T et al. | Novel lacto-ganglio type gangliosides with GM2-epitope in bovine brain which react with IgM from a patient of the amyotrophic lateral sclerosis-like disorder. | 1993 | J. Biol. Chem. | pmid:7691804 |
| Yamashiro S et al. | Genetic and enzymatic basis for the differential expression of GM2 and GD2 gangliosides in human cancer cell lines. | 1993 | Cancer Res. | pmid:8221677 |
| Heng HH et al. | Refined mapping of the GM2 activator protein (GM2A) locus to 5q31.3-q33.1, distal to the spinal muscular atrophy locus. | 1993 | Genomics | pmid:8288250 |
| Bellachioma G et al. | Cloning and sequence analysis of a cDNA clone coding for the mouse GM2 activator protein. | 1993 | Biochem. J. | pmid:7689829 |
| Swallow DM et al. | Regional localization of the gene coding for the GM2 activator protein (GM2A) to chromosome 5q32-33 and confirmation of the assignment of GM2AP to chromosome 3. | 1993 | Ann. Hum. Genet. | pmid:8257088 |
| Klima H et al. | Over-expression of a functionally active human GM2-activator protein in Escherichia coli. | 1993 | Biochem. J. | pmid:8503891 |
| Cheung NK et al. | Disialoganglioside GD2 anti-idiotypic monoclonal antibodies. | 1993 | Int. J. Cancer | pmid:8509225 |
| Obi T et al. | IgM M-protein in a patient with sensory-dominant neuropathy binds preferentially to polysialogangliosides. | 1992 | Acta Neurol. Scand. | pmid:1384262 |
| Schaeper RJ et al. | In vitro biosynthesis of GbOse4Cer (globoside) and GM2 ganglioside by the (1-->3) and (1-->4)-N-acetyl beta-D-galactosaminyltransferases from embryonic chicken brain. Solubilization, purification, and characterization of the transferases. | 1992 | Carbohydr. Res. | pmid:1291049 |
| Xie B et al. | Identification of a processed pseudogene related to the functional gene encoding the GM2 activator protein: localization of the pseudogene to human chromosome 3 and the functional gene to human chromosome 5. | 1992 | Genomics | pmid:1427911 |
| Nagata Y et al. | Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides. | 1992 | J. Biol. Chem. | pmid:1601877 |
| Xie B et al. | A Cys138-to-Arg substitution in the GM2 activator protein is associated with the AB variant form of GM2 gangliosidosis. | 1992 | Am. J. Hum. Genet. | pmid:1570834 |
| Dobrenis K et al. | Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1532255 |
| Renshaw PF et al. | Electroconvulsive therapy treatment of depression in a patient with adult GM2 gangliosidosis. | 1992 | Ann. Neurol. | pmid:1386210 |
| Navon R | Molecular and clinical heterogeneity of adult GM2 gangliosidosis. | 1991 | Dev. Neurosci. | pmid:1840100 |
| Suzuki K and Vanier MT | Biochemical and molecular aspects of late-onset GM2-gangliosidosis: B1 variant as a prototype. | 1991 | Dev. Neurosci. | pmid:1840099 |
| Federico A et al. | The clinical aspects of adult hexosaminidase deficiencies. | 1991 | Dev. Neurosci. | pmid:1840098 |
| Goodman LA et al. | Ectopic dendrites occur only on cortical pyramidal cells containing elevated GM2 ganglioside in alpha-mannosidosis. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1763046 |
| Dohi T et al. | Localization of UDP-GalNAc:NeuAc alpha 2,3Gal-R beta 1,4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human stomach. Enzymatic synthesis of a fundic gland-specific ganglioside and GM2. | 1991 | J. Biol. Chem. | pmid:1748676 |
| Chen S et al. | Quantitative analysis of the molecular species of monosialogangliosides by continuous-flow fast-atom bombardment mass spectrometry. | 1991 | Rapid Commun. Mass Spectrom. | pmid:1811797 |
| dos Santos MR et al. | GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene mutations in 11 patients from a defined region in Portugal. | 1991 | Am. J. Hum. Genet. | pmid:1832817 |
| Nakamura M et al. | Radioimmune assay of sialyltransferase and N-acetylgalactosaminyltransferase activities using specific antibodies on a 96-well filtration plate of a multiscreen assay system. | 1991 | Anal. Biochem. | pmid:1789418 |
| Schröder M et al. | A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB. | 1991 | FEBS Lett. | pmid:1915858 |
| Klima H et al. | Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein. | 1991 | FEBS Lett. | pmid:1915857 |
| Bjerkvig R et al. | Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line. | 1991 | Cancer Res. | pmid:1873810 |
| Xie B et al. | Isolation and expression of a full-length cDNA encoding the human GM2 activator protein. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2059210 |
| Hoffman LM et al. | SV-40 transformation: effect on GM2 ganglioside in cultured cell lines. | 1991 | Biochim. Biophys. Acta | pmid:1647206 |
| Liu YB and Chan KF | High-performance capillary electrophoresis of gangliosides. | 1991 | Electrophoresis | pmid:1889389 |
| Sindern E et al. | Serum antibodies to GM1 and GM3-gangliosides in systemic lupus erythematosus with chronic inflammatory demyelinating polyradiculoneuropathy. | 1991 | Acta Neurol. Scand. | pmid:1887763 |
| Mahuran DJ | The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis. | 1991 | Biochim. Biophys. Acta | pmid:1825792 |
| Meier EM et al. | The human GM2 activator protein. A substrate specific cofactor of beta-hexosaminidase A. | 1991 | J. Biol. Chem. | pmid:1824846 |
| Kono M et al. | Two pathways for GM2(NeuGc) expression in mice: genetic analysis. | 1991 | J. Biochem. | pmid:2016262 |
| Yavin E et al. | Nerve growth factor mediates monosialoganglioside-induced release of fibronectin and J1/tenascin from C6 glioma cells. | 1991 | J. Neurochem. | pmid:1702827 |
| Mitsuo K et al. | Juvenile Sandhoff disease: a Japanese patient carrying a mutation identical to that found earlier in a Canadian patient. | 1990 | J. Neurol. Sci. | pmid:2147031 |
| Yoshino H et al. | Abnormal glycosphingolipid metabolism in the nervous system of galactosialidosis. | 1990 | J. Neurol. Sci. | pmid:2115076 |
| Hanisch FG et al. | Glycosphingolipid expression on murine L1-fibrosarcoma cells: analysis of clonal in vivo and in vitro selected sublines with different lung colonisation potential. | 1990 | Br. J. Cancer | pmid:2372482 |
| Tonevitsky AG et al. | Effect of gangliosides on binding, internalization and cytotoxic activity of ricin. | 1990 | FEBS Lett. | pmid:2358071 |
| Trinchera M and Ghidoni R | Precursor-product relationship between GM1 and GD1a biosynthesized from exogenous GM2 ganglioside in rat liver. | 1990 | J. Biochem. | pmid:2358435 |
| Mahuran DJ et al. | The molecular basis of Tay-Sachs disease: mutation identification and diagnosis. | 1990 | Clin. Biochem. | pmid:2147596 |
| Trinchera M et al. | The N-acetylgalactosamine residue of exogenous GM2 ganglioside is recycled for glycoconjugate biosynthesis in rat liver. | 1990 | Biochem. J. | pmid:2310367 |
| Fürst W et al. | The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein. | 1990 | Eur. J. Biochem. | pmid:2209618 |
| Cantù L et al. | Evidence for spontaneous segregation phenomena in mixed micelles of gangliosides. | 1990 | Chem. Phys. Lipids | pmid:2289284 |
| Paw BH et al. | Juvenile GM2 gangliosidosis caused by substitution of histidine for arginine at position 499 or 504 of the alpha-subunit of beta-hexosaminidase. | 1990 | J. Biol. Chem. | pmid:2140574 |
| Dohi T et al. | Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosa. | 1990 | J. Biol. Chem. | pmid:2139874 |
| Yamaguchi H et al. | Human monoclonal antibody with dual GM2/GD2 specificity derived from an immunized melanoma patient. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2159145 |
| Karlsson G et al. | Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2. | 1990 | Biochim. Biophys. Acta | pmid:1691018 |
| Navon R et al. | Ashkenazi-Jewish and non-Jewish adult GM2 gangliosidosis patients share a common genetic defect. | 1990 | Am. J. Hum. Genet. | pmid:2278539 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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