| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kyrkanides S et al. | beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710246 |
| Masson E et al. | Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides. | 2005 | Biochem. J. | pmid:15654767 |
| Moran AP et al. | Antibodies induced by ganglioside-mimicking Campylobacter jejuni lipooligosaccharides recognise epitopes at the nodes of Ranvier. | 2005 | J. Neuroimmunol. | pmid:15993494 |
| Usuki S et al. | AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides. | 2005 | J. Neurol. Sci. | pmid:15850580 |
| Yamato O et al. | GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family of Japanese domestic cats. | 2004 | Vet. Rec. | pmid:15623087 |
| Cressant A et al. | Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum. | 2004 | J. Neurosci. | pmid:15537895 |
| Kunishige M et al. | Isolated cranial neuropathy associated with anti-glycolipid antibodies. | 2004 | J. Neurol. Sci. | pmid:15465085 |
| Aoki H et al. | Inhibition of motility and invasiveness of renal cell carcinoma induced by short interfering RNA transfection of beta 1,4GalNAc transferase. | 2004 | FEBS Lett. | pmid:15178323 |
| Andersen SM et al. | Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome. | 2004 | Org. Biomol. Chem. | pmid:15064799 |
| Higashi H and Chen NH | Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization. | 2004 | Glycoconj. J. | pmid:14973370 |
| Batuwangala T et al. | The crystal structure of human CD1b with a bound bacterial glycolipid. | 2004 | J. Immunol. | pmid:14764708 |
| Wendeler M et al. | Photoaffinity labelling of the human GM2-activator protein. Mechanistic insight into ganglioside GM2 degradation. | 2004 | Eur. J. Biochem. | pmid:14728689 |
| Yamaguchi A et al. | Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. | 2004 | J. Clin. Invest. | pmid:14722612 |
| Yamato O et al. | Laboratory diagnosis of canine GM2-gangliosidosis using blood and cerebrospinal fluid. | 2004 | J. Vet. Diagn. Invest. | pmid:14974845 |
| Krug LM et al. | Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin. | 2004 | Clin. Cancer Res. | pmid:14871967 |
| Wendeler M et al. | Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay. | 2003 | Meth. Enzymol. | pmid:14579597 |
| Li YT et al. | Structural basis for the enzymatic resistance of the GM2 ganglioside. | 2003 | Meth. Enzymol. | pmid:14579580 |
| Mauri L et al. | Procedure for separation of GM2 ganglioside species with different ceramide structures by a flash reversed-phase silica gel liquid chromatography. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14552811 |
| Brown ER and Ibrahim JG | A Bayesian semiparametric joint hierarchical model for longitudinal and survival data. | 2003 | Biometrics | pmid:12926706 |
| Li YT et al. | Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. | 2003 | J. Biol. Chem. | pmid:12829702 |
| Antoine T et al. | Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli. | 2003 | Chembiochem | pmid:12740812 |
| Mizutani K et al. | Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2. | 2003 | Intern. Med. | pmid:12705795 |
| Odaka M and Yuki N | Antibodies to GM2 ganglioside in neurological disorders. | 2003 | Intern. Med. | pmid:12705785 |
| Yamaguchi A et al. | Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease. | 2003 | J. Mol. Med. | pmid:12682727 |
| Rapoport E et al. | Ganglioside binding pattern of CD33-related siglecs. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639556 |
| Shimada Y et al. | Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin. | 2003 | J. Lipid Res. | pmid:12576516 |
| Chen HH et al. | Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene. | 2003 | Int. J. Cancer | pmid:12455030 |
| Sharma R et al. | A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside. | 2003 | Biochim. Biophys. Acta | pmid:12527415 |
| Irie S et al. | Detection of serum anti-ganglioside antibodies by latex agglutination assay in Guillain-Barré syndrome: comparison with ELISA. | 2003 | Intern. Med. | pmid:12857046 |
| Tada M et al. | [Steroid-pulse therapy in Guillain-Barré syndrome associated with cytomegalovirus infection: a case report]. | 2003 | No To Shinkei | pmid:12910997 |
| Pelled D et al. | Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. | 2003 | J. Biol. Chem. | pmid:12756243 |
| Wölfl M et al. | Gangliosides inhibit the development from monocytes to dendritic cells. | 2002 | Clin. Exp. Immunol. | pmid:12452834 |
| Martino S et al. | Restoration of the GM2 ganglioside metabolism in bone marrow-derived stromal cells from Tay-Sachs disease animal model. | 2002 | Neurochem. Res. | pmid:12374215 |
| Ravasi D et al. | Study of interaction of GM2 activator protein with GM2 using circular dichroism and fluorescence spectroscopy. | 2002 | Neurochem. Res. | pmid:12374214 |
| Jeyakumar M et al. | Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis. | 2002 | Neuropathol. Appl. Neurobiol. | pmid:12366816 |
| Jeyakumar M et al. | An inducible mouse model of late onset Tay-Sachs disease. | 2002 | Neurobiol. Dis. | pmid:12270683 |
| Niazi KR et al. | The CD1b structure: antigen presentation adapts to a high-fat diet. | 2002 | Nat. Immunol. | pmid:12145652 |
| Gadola SD et al. | Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. | 2002 | Nat. Immunol. | pmid:12118248 |
| Lopate G et al. | Severe sensory ataxia and demyelinating polyneuropathy with IgM anti-GM2 and GalNAc-GD1A antibodies. | 2002 | Muscle Nerve | pmid:12115971 |
| Myerowitz R et al. | Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling. | 2002 | Hum. Mol. Genet. | pmid:12019216 |
| Alaedini A et al. | Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay. | 2002 | J. Neurol. Sci. | pmid:11959155 |
| Martino S et al. | Absence of metabolic cross-correction in Tay-Sachs cells: implications for gene therapy. | 2002 | J. Biol. Chem. | pmid:11923278 |
| Sango K et al. | Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease. | 2002 | Neuropathol. Appl. Neurobiol. | pmid:11849560 |
| Mehta RR et al. | In vitro transformation of human congenital naevus to malignant melanoma. | 2002 | Melanoma Res. | pmid:11828255 |
| Guerry P et al. | Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro. | 2002 | Infect. Immun. | pmid:11796612 |
| Miljan EA et al. | Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides. | 2002 | J. Biol. Chem. | pmid:11796728 |
| Trindade VM et al. | Ganglioside alterations in the central nervous system of rats chronically injected with methylmalonic and propionic acids. | 2002 | Metab Brain Dis | pmid:12083341 |
| Taniguchi M et al. | Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain. | 2001 | Brain Dev. | pmid:11578853 |
| Gouni-Berthold I et al. | Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. | 2001 | Hypertension | pmid:11711493 |
| Li SC et al. | Degradation of G(M1) and G(M2) by mammalian sialidases. | 2001 | Biochem. J. | pmid:11696012 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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