Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GM2?

Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GM2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GM2?

Related references are published most in these journals:

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What functions are associated with Ganglioside GM2?


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What lipids are associated with Ganglioside GM2?

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What genes are associated with Ganglioside GM2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GM2?

Disease model

Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Ganglioside GM2

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Authors Title Published Journal PubMed Link
Young WW et al. Production of monoclonal antibodies specific for two distinct steric portions of the glycolipid ganglio-N-triosylceramide (asialo GM2). 1979 J. Exp. Med. pmid:512581
O'Brien JS and Geiger B Normal adult with absent HEX A: immunoreactive HEX A is present. 1979 Am. J. Hum. Genet. pmid:507054
Novak A et al. Preparation of radiolabeled GM2 and GA2 gangliosides. 1979 J. Lipid Res. pmid:490046
Li SC et al. Evidence for the presence of two separate protein activators for the enzymic hydrolysis of GM1 and GM2 gangliosides. 1979 J. Biol. Chem. pmid:115863
Hadfield MG et al. Pathologic findings in mucopolysaccharidosis type IIIB (Sanfilippo's sydnrome B). 1980 Arch. Neurol. pmid:6775621
Suzuki Y et al. Action of ortho- and paramyxovirus neuraminidase on gangliosides. Hydrolysis of ganglioside GM1 by Sendai virus neuraminidase. 1980 Biochim. Biophys. Acta pmid:6257300
Johnson WG et al. Alpha-locus hexosaminidase genetic compound with juvenile gangliosidosis phenotype: clinical, genetic, and biochemical studies. 1980 Am. J. Hum. Genet. pmid:6772023
Hechtman P and Kachra Z Interaction of activating protein and surfactants with human liver hexosaminidase A and GM2 ganglioside. 1980 Biochem. J. pmid:7387624
Holmgren J et al. Polystyrene-adsorbed gangliosides for investigation of the structure of the tetanus-toxin receptor. 1980 Eur. J. Biochem. pmid:7398619
Chien JL and Hogan EL Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. 1980 Biochim. Biophys. Acta pmid:7236652