| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miyake M et al. | The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors. A study with specific monoclonal antibodies. | 1990 | Cancer | pmid:2153431 |
| Nakamura K et al. | Genetic regulation of GM4(NeuAc) expression in mouse erythrocytes. | 1990 | J. Biochem. | pmid:2332419 |
| Baba H et al. | Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. | 1989 | J. Neuroimmunol. | pmid:2584393 |
| Singer HS and Cork LC | Canine GM2 gangliosidosis: morphological and biochemical analysis. | 1989 | Vet. Pathol. | pmid:2540585 |
| Livingston PO et al. | Characterization of IgG and IgM antibodies induced in melanoma patients by immunization with purified GM2 ganglioside. | 1989 | Cancer Res. | pmid:2582446 |
| Zvezdina ND et al. | Gangliosides of sea urchin embryos. Their localization and participation in early development. | 1989 | Eur. J. Biochem. | pmid:2598928 |
| Vrionis FD et al. | Five new epitope-defined monoclonal antibodies reactive with GM2 and human glioma and medulloblastoma cell lines. | 1989 | Cancer Res. | pmid:2479468 |
| Ghidoni R et al. | Metabolism of exogenous gangliosides in cerebellar granule cells, differentiated in culture. | 1989 | J. Neurochem. | pmid:2795018 |
| Dotta F et al. | Ganglioside expression in human pancreatic islets. | 1989 | Diabetes | pmid:2695376 |
| Fredman P et al. | A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium. | 1989 | J. Biol. Chem. | pmid:2473071 |
| Schröder M et al. | Isolation of a cDNA encoding the human GM2 activator protein. | 1989 | FEBS Lett. | pmid:2753159 |
| DeGasperi R et al. | Isolation and characterization of an activator protein for the hydrolysis of ganglioside GM2 from the roe of striped mullet (Mugil cephalus). | 1989 | Biochem. J. | pmid:2527497 |
| Hoon DS et al. | Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells. | 1989 | Int. J. Cancer | pmid:2714890 |
| Riboni L et al. | Formation of ganglioside GD1b-lactone in rat brain from intracisternally administered GD1b. | 1989 | J. Neurochem. | pmid:2709011 |
| Walton KM and Schnaar RL | Coordinate regulation of ganglioside glycosyltransferases in differentiating NG108-15 neuroblastoma x glioma cells. | 1989 | J. Neurochem. | pmid:2540274 |
| Hechtman P et al. | The mutation mechanism causing juvenile-onset Tay-Sachs disease among Lebanese. | 1989 | Clin. Genet. | pmid:2527097 |
| Irie RF et al. | Human monoclonal antibody to ganglioside GM2 for melanoma treatment. | 1989 | Lancet | pmid:2564593 |
| Paw BH et al. | Molecular basis of adult-onset and chronic GM2 gangliosidoses in patients of Ashkenazi Jewish origin: substitution of serine for glycine at position 269 of the alpha-subunit of beta-hexosaminidase. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2522660 |
| Ilyas AA et al. | Gangliosides GM2, IV4GalNAcGM1b, and IV4GalNAcGC1a as antigens for monoclonal immunoglobulin M in neuropathy associated with gammopathy. | 1988 | J. Biol. Chem. | pmid:2450092 |
| Sanai Y et al. | Monoclonal antibody directed to a Hanganutziu-Deicher active ganglioside, GM2 (NeuGc). | 1988 | Biochim. Biophys. Acta | pmid:2449247 |
| Jolivet-Reynaud C et al. | Damaging effects of Clostridium perfringens delta toxin on blood platelets and their relevance to ganglioside GM2. | 1988 | Arch. Biochem. Biophys. | pmid:3162668 |
| Kushi Y et al. | Direct analysis of glycolipids on thin-layer plates by matrix-assisted secondary ion mass spectrometry: application for glycolipid storage disorders. | 1988 | Anal. Biochem. | pmid:3149874 |
| Miyake M et al. | Generation of two murine monoclonal antibodies that can discriminate N-glycolyl and N-acetyl neuraminic acid residues of GM2 gangliosides. | 1988 | Cancer Res. | pmid:3167861 |
| Tanaka A et al. | GM2-gangliosidosis B1 variant: a wide geographic and ethnic distribution of the specific beta-hexosaminidase alpha chain mutation originally identified in a Puerto Rican patient. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2973311 |
| Lichtenberg P et al. | Post-partum psychosis in adult GM2 gangliosidosis. A case report. | 1988 | Br J Psychiatry | pmid:2977954 |
| Budde-Steffen C et al. | Presence of beta-hexosaminidase A alpha-chain mRNA in two different variants of GM2-gangliosidosis. | 1988 | Neuropediatrics | pmid:2967444 |
| Torres BV et al. | Glycolipid-lectin interactions: reactivity of lectins from Helix pomatia, Wisteria floribunda, and Dolichos biflorus with glycolipids containing N-acetylgalactosamine. | 1988 | Arch. Biochem. Biophys. | pmid:3355161 |
| Naoi M et al. | Specific binding of glycosylated beta-galactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides. | 1988 | J. Neurochem. | pmid:3126266 |
| DeGasperi R et al. | A GM2-specific beta-hexosaminidase from the roe of striped mullet (Mugil cephalus). | 1988 | J. Biol. Chem. | pmid:2961751 |
| Ohno K and Suzuki K | Mutation in GM2-gangliosidosis B1 variant. | 1988 | J. Neurochem. | pmid:2961848 |
| Ishikawa Y et al. | Biochemical basis of type AB GM2 gangliosidosis in a Japanese spaniel. | 1987 | J. Neurochem. | pmid:2949061 |
| Li YT et al. | Occurrence of ceramide-glycanase in the earthworm, Lumbricus terrestris. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3689409 |
| Nagai K and Ishizuka I | Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain. | 1987 | J. Biochem. | pmid:3115968 |
| Naoi M et al. | Ganglioside GM1 causes expression of type B monoamine oxidase in a rat clonal pheochromocytoma cell line, PC12h. | 1987 | J. Neurochem. | pmid:3117976 |
| Rosengren B et al. | Composition of gangliosides and neutral glycosphingolipids of brain in classical Tay-Sachs and Sandhoff disease: more lyso-GM2 in Sandhoff disease? | 1987 | J. Neurochem. | pmid:3612128 |
| Eto Y et al. | Partial deficiency of beta-hexosaminidase activity in canine GM2-gangliosidosis. | 1987 | Tohoku J. Exp. Med. | pmid:2958961 |
| Yamanaka T et al. | Detection of gangliotriaose-series glycosphingolipids in serum of cord blood and patients with neuroblastoma by a sensitive TLC/enzyme-immunostaining method. | 1987 | Biochim. Biophys. Acta | pmid:3300782 |
| Ando I et al. | Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells. | 1987 | Int. J. Cancer | pmid:3596830 |
| Yanagisawa K et al. | Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver. | 1987 | Biochim. Biophys. Acta | pmid:3109491 |
| Harding AE et al. | Adult onset supranuclear ophthalmoplegia, cerebellar ataxia, and neurogenic proximal muscle weakness in a brother and sister: another hexosaminidase A deficiency syndrome. | 1987 | J. Neurol. Neurosurg. Psychiatry | pmid:2956362 |
| Livingston PO et al. | Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3472242 |
| Livingston PO et al. | Approaches to augmenting the immunogenicity of the ganglioside GM2 in mice: purified GM2 is superior to whole cells. | 1987 | J. Immunol. | pmid:3805726 |
| Dawson G et al. | Regulation of GM2 ganglioside metabolism in cultured cells. | 1986 | Chem. Phys. Lipids | pmid:3549015 |
| Wynn CH and Robson B | Calculation of the conformation of glycosphingolipids. 2. GM1- and GM2-gangliosides. | 1986 | J. Theor. Biol. | pmid:3626589 |
| Sugimoto M et al. | Total synthesis of gangliosides GM1 and GM2. | 1986 | Carbohydr. Res. | pmid:3815403 |
| Natoli EJ et al. | A murine monoclonal antibody detecting N-acetyl- and N-glycolyl-GM2: characterization of cell surface reactivity. | 1986 | Cancer Res. | pmid:3731079 |
| Cavaillon JM et al. | Ganglioside identification on human monocyte membrane with Clostridium perfringens delta-toxin. | 1986 | J. Leukoc. Biol. | pmid:2872258 |
| Zeigler M and Bach G | Internalization of exogenous gangliosides in cultured skin fibroblasts for the diagnosis of mucolipidosis IV. | 1986 | Clin. Chim. Acta | pmid:3087662 |
| Charrow J and Binns HJ | Ganglioside loading of cultured fibroblasts: a provocative method for the diagnosis of the GM2 gangliosidoses. | 1986 | Clin. Chim. Acta | pmid:2938852 |
| Kotagal S et al. | AB variant GM2 gangliosidosis: cerebrospinal fluid and neuropathologic characteristics. | 1986 | Neurology | pmid:3081832 |
| Dahiya R and Brasitus TA | Glycosphingolipid patterns of fetal and adult small intestinal mucosa in the sheep. | 1986 | Biochim. Biophys. Acta | pmid:3942764 |
| Kotagal S | Diagnosis of AB variant, GM2 gangliosidosis. | 1986 | Ann. Neurol. | pmid:3080943 |
| Miyagi T and Tsuiki S | Evidence for sialidase hydrolyzing gangliosides GM2 and GM1 in rat liver plasma membrane. | 1986 | FEBS Lett. | pmid:3758350 |
| Oates CE et al. | Movement disorders associated with chronic GM2 gangliosidosis. Case report and review of the literature. | 1986 | Eur. Neurol. | pmid:3081350 |
| Berry-Kravis E and Dawson G | Possible role of gangliosides in regulating an adenylate cyclase-linked 5-hydroxytryptamine (5-HT1) receptor. | 1985 | J. Neurochem. | pmid:2997394 |
| Raghavan SS et al. | GM2-ganglioside metabolism in hexosaminidase A deficiency states: determination in situ using labeled GM2 added to fibroblast cultures. | 1985 | Am. J. Hum. Genet. | pmid:2934978 |
| Ishizuka I et al. | Preparation and enzymatic degradation of monosulfogangliotriaosylceramide. | 1985 | J. Biol. Chem. | pmid:3928630 |
| Sasaki T | Glycolipid-binding proteins. | 1985 | Chem. Phys. Lipids | pmid:4064224 |
| Higashi H et al. | Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer. | 1985 | Cancer Res. | pmid:3874688 |
| Iwamori M et al. | Brain gangliosides of quaking and shiverer mutants: qualitative and quantitative changes of monosialogangliosides in the quaking brain. | 1985 | J. Neurochem. | pmid:3998734 |
| Kytzia HJ and Sandhoff K | Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A. | 1985 | J. Biol. Chem. | pmid:3158659 |
| Kasai N et al. | Preparation and specificity of avian anti-GM2(NeuGc) ganglioside antiserum. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3925943 |
| Sonderfeld S et al. | Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects. | 1985 | Eur. J. Biochem. | pmid:3922757 |
| Raghavan S et al. | GM2-ganglioside metabolism in cultured human skin fibroblasts: unambiguous diagnosis of GM2-gangliosidosis. | 1985 | Biochim. Biophys. Acta | pmid:3995063 |
| Burg J et al. | Mapping of the gene coding for the human GM2 activator protein to chromosome 5. | 1985 | Ann. Hum. Genet. | pmid:3865618 |
| Navon R et al. | Hereditary heat-labile hexosaminidase B: a variant whose homozygotes synthesize a functional HEX A. | 1985 | Am. J. Hum. Genet. | pmid:3156493 |
| Wenger DA | Diagnosis of atypical patients with lipid storage diseases. | 1985 | Brain Dev. | pmid:4014607 |
| Li SC et al. | Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide. | 1985 | J. Biol. Chem. | pmid:2981875 |
| Wood PA et al. | Fluorescence polarization analysis, lipid composition, and Na+, K+-ATPase kinetics of synaptosomal membranes in feline GM1 and GM2 gangliosidosis. | 1985 | J. Neurochem. | pmid:2983023 |
| Seyfried TN et al. | Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. | 1984 | J. Neurochem. | pmid:6470710 |
| Sandhoff K and Conzelmann E | The biochemical basis of gangliosidoses. | 1984 | Neuropediatrics | pmid:6242704 |
| Goebel HH | Morphology of the gangliosidoses. | 1984 | Neuropediatrics | pmid:6100800 |
| Di Gregorio F et al. | The influence of gangliosides on neurite growth and regeneration. | 1984 | Neuropediatrics | pmid:6100799 |
| Pampiglione G and Harden A | Neurophysiological investigations in GM1 and GM2 gangliosidoses. | 1984 | Neuropediatrics | pmid:6100798 |
| Schulte FJ | Clinical course of GM2 gangliosidoses. A correlative attempt. | 1984 | Neuropediatrics | pmid:6100797 |
| Li YT et al. | Isolation and characterization of a novel phytosphingosine-containing GM2 ganglioside from mullet roe (Mugil cephalus). | 1984 | J. Biol. Chem. | pmid:6746635 |
| Schwab ME and Vassella F | Synopsis: gangliosidoses. | 1984 | Neuropediatrics | pmid:6100793 |
| Meek D et al. | Juvenile progressive dystonia: a new phenotype of GM2 gangliosidosis. | 1984 | Ann. Neurol. | pmid:6430210 |
| Scheideler MA et al. | Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line. | 1984 | J. Neurochem. | pmid:6422000 |
| Itoh H et al. | The fine structure of cytoplasmic inclusions in brain and other visceral organs in Sandhoff disease. | 1984 | Brain Dev. | pmid:6097133 |
| Kadowaki H et al. | Separation of brain monosialoganglioside molecular species by high-performance liquid chromatography. | 1984 | J. Lipid Res. | pmid:6512419 |
| Fishman PH et al. | The role of gangliosides in the interaction of human chorionic gonadotropin and cholera toxin with murine Leydig tumor cells. | 1984 | J. Biol. Chem. | pmid:6330091 |
| Li SC et al. | Effect of modification of sialic acid on enzymic hydrolysis of gangliosides GM1 and GM2. | 1984 | J. Biol. Chem. | pmid:6232275 |
| Nojiri H et al. | Characteristic expression of glycosphingolipid profiles in the bipotential cell differentiation of human promyelocytic leukemia cell line HL-60. | 1984 | Blood | pmid:6589019 |
| Yu RK et al. | Characterization of some minor gangliosides in Tay-Sachs brains. | 1983 | Brain Res. | pmid:6414648 |
| Kniep B et al. | Gangliotriaosylceramide (asialo GM2), a glycosphingolipid marker for cell lines derived from patients with Hodgkin's disease. | 1983 | J. Immunol. | pmid:6886427 |
| Conzelmann E et al. | Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level. | 1983 | Am. J. Hum. Genet. | pmid:6614006 |
| Tai T et al. | Ganglioside GM2 as a human tumor antigen (OFA-I-1). | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6193515 |
| Yusuf HK et al. | Ganglioside biosynthesis in Golgi apparatus of rat liver. Stimulation by phosphatidylglycerol and inhibition by tunicamycin. | 1983 | Eur. J. Biochem. | pmid:6861762 |
| Inui K et al. | Juvenile GM2 gangliosidosis (AMB variant): inability to activate hexosaminidase A by activator protein. | 1983 | Am. J. Hum. Genet. | pmid:6224417 |
| Li YT et al. | Differentiation of two variants of type-AB GM2-gangliosidosis using chromogenic substrates. | 1983 | Am. J. Hum. Genet. | pmid:6222647 |
| Hashimoto Y et al. | Genetic regulation of GM2 expression in liver of mouse. | 1983 | J. Biochem. | pmid:6874670 |
| Kaplan F and Hechtman P | Purification and properties of two enzymes catalyzing galactose transfer to GM2 ganglioside from rat liver Golgi. | 1983 | J. Biol. Chem. | pmid:6401719 |
| Hirabayashi Y et al. | The protein activator specific for the enzymic hydrolysis of GM2 ganglioside in normal human brain and brains of three types of GM2 gangliosidosis. | 1983 | J. Neurochem. | pmid:6848657 |
| Young WW et al. | Decreased glycolipid antigen expression in lymphoma cell variants escaping from anti-glycolipid serotherapy. | 1983 | J. Exp. Med. | pmid:6848617 |
| Harzer K | Assay of the GM2-ganglioside cleaving hexosaminidase activity of skin fibroblasts for GM2-gangliosidoses. | 1983 | Clin. Chim. Acta | pmid:6228344 |
| Watanabe T et al. | Human melanoma antigen AH is an autoantigenic ganglioside related to GD2. | 1982 | J. Exp. Med. | pmid:7175442 |
| Hasilik A et al. | Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6214395 |
| Poulos A et al. | Diagnosis of Tay-Sachs disease using [3H]N-acetylneuraminic acid labelled GM2 ganglioside as substrate. | 1982 | Clin. Chim. Acta | pmid:6210469 |
| Conzelmann E et al. | Complexing of glycolipids and their transfer between membranes by the activator protein for degradation of lysosomal ganglioside GM2. | 1982 | Eur. J. Biochem. | pmid:6210531 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.