| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xie B et al. | Biochemical characterization of the Cys138Arg substitution associated with the AB variant form of GM2 gangliosidosis: evidence that Cys138 is required for the recognition of the GM2 activator/GM2 ganglioside complex by beta-hexosaminidase A. | 1998 | Biochemistry | pmid:9454570 |
| Rigat B et al. | Two mechanisms for the recapture of extracellular GM2 activator protein: evidence for a major secretory form of the protein. | 1997 | Biochemistry | pmid:9204879 |
| Hou Y et al. | Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A. | 1996 | Biochemistry | pmid:8672428 |
| Martinez Z et al. | GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. | 2007 | Biochemistry | pmid:17253773 |
| Raghavan S et al. | GM2-ganglioside metabolism in cultured human skin fibroblasts: unambiguous diagnosis of GM2-gangliosidosis. | 1985 | Biochim. Biophys. Acta | pmid:3995063 |
| Hoffman LM et al. | Human fetal brain cells in culture. Increase in GM2 ganglioside after SV-40 transformation. | 1981 | Biochim. Biophys. Acta | pmid:6271225 |
| Suzuki Y et al. | Action of ortho- and paramyxovirus neuraminidase on gangliosides. Hydrolysis of ganglioside GM1 by Sendai virus neuraminidase. | 1980 | Biochim. Biophys. Acta | pmid:6257300 |
| Mahuran DJ | Biochemical consequences of mutations causing the GM2 gangliosidoses. | 1999 | Biochim. Biophys. Acta | pmid:10571007 |
| Mahuran DJ | The GM2 activator protein, its roles as a co-factor in GM2 hydrolysis and as a general glycolipid transport protein. | 1998 | Biochim. Biophys. Acta | pmid:9714704 |
| Sato T et al. | Quantitative measurements of the interaction between monosialoganglioside monolayers and wheat germ agglutinin (WGA) by a quartz-crystal microbalance. | 1998 | Biochim. Biophys. Acta | pmid:9545544 |
| Smiljanic-Georgijev N et al. | Characterization of the affinity of the G(M2) activator protein for glycolipids by a fluorescence dequenching assay. | 1997 | Biochim. Biophys. Acta | pmid:9187239 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Sanai Y et al. | Monoclonal antibody directed to a Hanganutziu-Deicher active ganglioside, GM2 (NeuGc). | 1988 | Biochim. Biophys. Acta | pmid:2449247 |
| Kundu M et al. | Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. | 2016 | Biochim. Biophys. Acta | pmid:27066976 |
| Taga S et al. | Sequential changes in glycolipid expression during human B cell differentiation: enzymatic bases. | 1995 | Biochim. Biophys. Acta | pmid:7811747 |
| Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
| Karlsson G et al. | Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2. | 1990 | Biochim. Biophys. Acta | pmid:1691018 |
| Li YT et al. | Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility. | 2008 | Biochim. Biophys. Acta | pmid:17967427 |
| Yamanaka T et al. | Detection of gangliotriaose-series glycosphingolipids in serum of cord blood and patients with neuroblastoma by a sensitive TLC/enzyme-immunostaining method. | 1987 | Biochim. Biophys. Acta | pmid:3300782 |
| Yanagisawa K et al. | Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver. | 1987 | Biochim. Biophys. Acta | pmid:3109491 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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