| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wendeler M et al. | The enzyme-binding region of human GM2-activator protein. | 2006 | FEBS J. | pmid:16478472 |
| Kirvan CA et al. | Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea. | 2006 | Autoimmunity | pmid:16455579 |
| Arfi A et al. | Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase alpha and beta. | 2006 | J. Neurochem. | pmid:16441513 |
| Ledeen RW and Wu G | Gangliosides of the nuclear membrane: a crucial locus of cytoprotective modulation. | 2006 | J. Cell. Biochem. | pmid:16408301 |
| Jacques S et al. | Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications. | 2006 | Org. Biomol. Chem. | pmid:16358009 |
| Sakuraba H et al. | Molecular pathologies of and enzyme replacement therapies for lysosomal diseases. | 2006 | CNS Neurol Disord Drug Targets | pmid:16918392 |
| Fuse T et al. | Synthesis and enzymatic susceptibility of a series of novel GM2 analogs. | 2006 | Glycoconj. J. | pmid:16897176 |
| Itakura T et al. | Inefficiency in GM2 ganglioside elimination by human lysosomal beta-hexosaminidase beta-subunit gene transfer to fibroblastic cell line derived from Sandhoff disease model mice. | 2006 | Biol. Pharm. Bull. | pmid:16880605 |
| Crawley AC et al. | Characterization of a C57BL/6 congenic mouse strain of mucopolysaccharidosis type IIIA. | 2006 | Brain Res. | pmid:16828069 |
| Biswas K et al. | GM2 expression in renal cell carcinoma: potential role in tumor-induced T-cell dysfunction. | 2006 | Cancer Res. | pmid:16818659 |
| Thiesen PH et al. | Glycolipids from a colloid chemical point of view. | 2006 | J. Biotechnol. | pmid:16707183 |
| Bruce AF et al. | Functional characterisation of a nematode secreted GM2-activator protein. | 2006 | Mol. Biochem. Parasitol. | pmid:16569450 |
| Yin J et al. | Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. | 2006 | Cancer Res. | pmid:16540641 |
| Ragupathi G et al. | Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. | 2006 | J. Am. Chem. Soc. | pmid:16492059 |
| Sango K et al. | Impaired neurite outgrowth in the retina of a murine model of Sandhoff disease. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16123447 |
| Tsuji D et al. | Metabolic correction in microglia derived from Sandhoff disease model mice. | 2005 | J. Neurochem. | pmid:16092933 |
| Schwarzmann G et al. | Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system. | 2005 | Glycobiology | pmid:16079415 |
| Retter MW et al. | Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts. | 2005 | Cancer Res. | pmid:16024647 |
| Blixt O et al. | Chemoenzymatic synthesis of 2-azidoethyl-ganglio-oligosaccharides GD3, GT3, GM2, GD2, GT2, GM1, and GD1a. | 2005 | Carbohydr. Res. | pmid:16005859 |
| Arfi A et al. | Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts. | 2005 | Neurobiol. Dis. | pmid:15953731 |
Ganglioside GM2
Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GM2?
Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GM2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GM2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GM2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GM2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GM2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GM2?
Disease model
Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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