Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

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Introduction

To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GM2?

Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GM2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GM2?

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What functions are associated with Ganglioside GM2?


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What lipids are associated with Ganglioside GM2?

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What genes are associated with Ganglioside GM2?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GM2?

Disease model

Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Ganglioside GM2

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Authors Title Published Journal PubMed Link
Odaka M and Yuki N Antibodies to GM2 ganglioside in neurological disorders. 2003 Intern. Med. pmid:12705785
Mizutani K et al. Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2. 2003 Intern. Med. pmid:12705795
Antoine T et al. Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli. 2003 Chembiochem pmid:12740812
Pelled D et al. Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. 2003 J. Biol. Chem. pmid:12756243
Li YT et al. Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. 2003 J. Biol. Chem. pmid:12829702
Irie S et al. Detection of serum anti-ganglioside antibodies by latex agglutination assay in Guillain-Barré syndrome: comparison with ELISA. 2003 Intern. Med. pmid:12857046
Schaeper RJ et al. In vitro biosynthesis of GbOse4Cer (globoside) and GM2 ganglioside by the (1-->3) and (1-->4)-N-acetyl beta-D-galactosaminyltransferases from embryonic chicken brain. Solubilization, purification, and characterization of the transferases. 1992 Carbohydr. Res. pmid:1291049
Tada M et al. [Steroid-pulse therapy in Guillain-Barré syndrome associated with cytomegalovirus infection: a case report]. 2003 No To Shinkei pmid:12910997
Brown ER and Ibrahim JG A Bayesian semiparametric joint hierarchical model for longitudinal and survival data. 2003 Biometrics pmid:12926706
Obi T et al. IgM M-protein in a patient with sensory-dominant neuropathy binds preferentially to polysialogangliosides. 1992 Acta Neurol. Scand. pmid:1384262