Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GM2?

Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GM2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GM2?

Related references are published most in these journals:

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What functions are associated with Ganglioside GM2?


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What lipids are associated with Ganglioside GM2?

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What genes are associated with Ganglioside GM2?

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What common seen animal models are associated with Ganglioside GM2?

Disease model

Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ganglioside GM2

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Authors Title Published Journal PubMed Link
Yamato O et al. GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family of Japanese domestic cats. 2004 Vet. Rec. pmid:15623087
Cressant A et al. Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum. 2004 J. Neurosci. pmid:15537895
Kunishige M et al. Isolated cranial neuropathy associated with anti-glycolipid antibodies. 2004 J. Neurol. Sci. pmid:15465085
Aoki H et al. Inhibition of motility and invasiveness of renal cell carcinoma induced by short interfering RNA transfection of beta 1,4GalNAc transferase. 2004 FEBS Lett. pmid:15178323
Yamaguchi A et al. Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. 2004 J. Clin. Invest. pmid:14722612
Wendeler M et al. Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay. 2003 Meth. Enzymol. pmid:14579597
Li YT et al. Structural basis for the enzymatic resistance of the GM2 ganglioside. 2003 Meth. Enzymol. pmid:14579580
Mauri L et al. Procedure for separation of GM2 ganglioside species with different ceramide structures by a flash reversed-phase silica gel liquid chromatography. 2003 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:14552811
Brown ER and Ibrahim JG A Bayesian semiparametric joint hierarchical model for longitudinal and survival data. 2003 Biometrics pmid:12926706
Li YT et al. Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. 2003 J. Biol. Chem. pmid:12829702
Antoine T et al. Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli. 2003 Chembiochem pmid:12740812
Mizutani K et al. Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2. 2003 Intern. Med. pmid:12705795
Odaka M and Yuki N Antibodies to GM2 ganglioside in neurological disorders. 2003 Intern. Med. pmid:12705785
Yamaguchi A et al. Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease. 2003 J. Mol. Med. pmid:12682727
Rapoport E et al. Ganglioside binding pattern of CD33-related siglecs. 2003 Bioorg. Med. Chem. Lett. pmid:12639556
Shimada Y et al. Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin. 2003 J. Lipid Res. pmid:12576516
Sharma R et al. A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside. 2003 Biochim. Biophys. Acta pmid:12527415
Irie S et al. Detection of serum anti-ganglioside antibodies by latex agglutination assay in Guillain-Barré syndrome: comparison with ELISA. 2003 Intern. Med. pmid:12857046
Tada M et al. [Steroid-pulse therapy in Guillain-Barré syndrome associated with cytomegalovirus infection: a case report]. 2003 No To Shinkei pmid:12910997
Pelled D et al. Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. 2003 J. Biol. Chem. pmid:12756243