MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Manna M et al. | Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation. | 2017 | Biochim. Biophys. Acta | pmid:28143757 |
Patel DS et al. | Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature. | 2016 | Biophys. J. | pmid:27806280 |
Takehara M et al. | Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils. | 2016 | Biol. Pharm. Bull. | pmid:27725448 |
Wu G et al. | Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca²⺠influx. | 2016 | J. Neurochem. | pmid:26526326 |
Tsai YT et al. | GM1 Ganglioside is Involved in Epigenetic Activation Loci of Neuronal Cells. | 2016 | Neurochem. Res. | pmid:26498762 |
Li-Mao YJ et al. | Monosialotetrahexosylganglioside protect cerebral ischemia/reperfusion injury through upregulating the expression of tyrosine hydroxylase by inhibiting lipid peroxidation. | 2016 | Biomed. Pharmacother. | pmid:27847214 |
Liang Y et al. | The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells. | 2016 | Cell Biochem. Funct. | pmid:27558076 |
Van Blerkom J and Zimmermann S | Ganglioside-enriched microdomains define an oolemma that is functionally polarized with respect to fertilizability in the mouse. | 2016 | Reprod. Biomed. Online | pmid:27515228 |
Ji S et al. | Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27644882 |
Fricke N and Dimova R | GM1 Softens POPC Membranes and Induces the Formation of Micron-Sized Domains. | 2016 | Biophys. J. | pmid:27806275 |