MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vahed M et al. | Analysis of Physicochemical Interaction of Aβ with a GM1 Ganglioside-Containing Lipid Membrane. | 2018 | J Phys Chem B | pmid:29536735 |
Islam Z et al. | FAS promoter polymorphisms and serum sFas level are associated with increased risk of nerve damage in Bangladeshi patients with Guillain-Barré syndrome. | 2018 | PLoS ONE | pmid:29432441 |
Rodi PM et al. | Direct visualization of the lateral structure of giant vesicles composed of pseudo-binary mixtures of sulfatide, asialo-GM1 and GM1 with POPC. | 2018 | Biochim. Biophys. Acta | pmid:29106974 |
Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
Komura N et al. | Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. | 2017 | Meth. Enzymol. | pmid:28935104 |
Watanabe H et al. | Lipid raft dynamics linked to sperm competency for fertilization in mice. | 2017 | Genes Cells | pmid:28425215 |
Simón L et al. | Manchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model. | 2017 | PLoS ONE | pmid:28241054 |
Chiricozzi E et al. | Role of the GM1 ganglioside oligosaccharide portion in the TrkA-dependent neurite sprouting in neuroblastoma cells. | 2017 | J. Neurochem. | pmid:28796418 |
Zhang Y et al. | Enhanced soluble production of cholera toxin B subunit in Escherichia coli by co-expression of SKP chaperones. | 2017 | Protein Expr. Purif. | pmid:28673733 |
Ceccarelli A et al. | New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains. | 2017 | Biochim. Biophys. Acta | pmid:28499815 |
Rondelli V et al. | Building a biomimetic membrane for neutron reflectivity investigation: Complexity, asymmetry and contrast. | 2017 | Biophys. Chem. | pmid:28499578 |
Cebecauer M et al. | Impact of GM1 on Membrane-Mediated Aggregation/Oligomerization of β-Amyloid: Unifying View. | 2017 | Biophys. J. | pmid:28410623 |
Zou D et al. | Penetration of blood-brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system. | 2017 | Int J Nanomedicine | pmid:28744122 |
Su D et al. | Monosialotetrahexosy-1 ganglioside attenuates diabetes-associated cerebral ischemia/reperfusion injury through suppression of the endoplasmic reticulum stress-induced apoptosis. | 2017 | J Clin Neurosci | pmid:28392211 |
Marty P et al. | Fortuitous Diagnosis of Preexisting Neuropathy During Ultrasound-Guided Regional Anesthesia Performance: A Case Report. | 2017 | A A Case Rep | pmid:28368901 |
Han TH et al. | Transient Isolated Lower Bulbar Palsy With Elevated Serum Anti-GM1 and Anti-GD1b Antibodies During Aripiprazole Treatment. | 2017 | Pediatr. Neurol. | pmid:28341090 |
Wang Y et al. | IgG-degrading enzyme of Streptococcus pyogenes (IdeS) prevents disease progression and facilitates improvement in a rabbit model of Guillain-Barré syndrome. | 2017 | Exp. Neurol. | pmid:28214515 |
Han YB et al. | Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases. | 2017 | J. Biol. Chem. | pmid:28179425 |
Manna M et al. | Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation. | 2017 | Biochim. Biophys. Acta | pmid:28143757 |
Patra M et al. | Localization and dynamics of the anticarcinogenic curcumin with GM1 and other miceller assemblies. | 2017 | Glycoconj. J. | pmid:27866299 |
Iwamori M et al. | Enhanced fucosylation of GA1 in the digestive tracts of X-ray-irradiated mice. | 2017 | Glycoconj. J. | pmid:27858203 |
Das PK et al. | Aqueous RAFT Synthesis of Glycopolymers for Determination of Saccharide Structure and Concentration Effects on Amyloid β Aggregation. | 2017 | Biomacromolecules | pmid:28893064 |
Dai R et al. | Enhanced Autophagy Contributes to Protective Effects of GM1 Ganglioside Against Aβ1-42-Induced Neurotoxicity and Cognitive Deficits. | 2017 | Neurochem. Res. | pmid:28497346 |
Kasahara R et al. | The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes. | 2017 | Neuroscience | pmid:27815022 |
Cardona C et al. | Localization patterns of the ganglioside G in human sperm are indicative of male fertility and independent of traditional semen measures. | 2017 | Mol. Reprod. Dev. | pmid:28418610 |
Rajamanickam GD et al. | Content of testis-specific isoform of Na/K-ATPase (ATP1A4) is increased during bovine sperm capacitation through translation in mitochondrial ribosomes. | 2017 | Cell Tissue Res. | pmid:27807702 |
Chung TW et al. | The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis. | 2017 | Oncotarget | pmid:28032600 |
Tang B et al. | An in vivo study of hypoxia-inducible factor-1α signaling in ginsenoside Rg1-mediated brain repair after hypoxia/ischemia brain injury. | 2017 | Pediatr. Res. | pmid:27632778 |
Brocca P et al. | Water response to ganglioside GM1 surface remodelling. | 2017 | Biochim. Biophys. Acta | pmid:27155581 |
Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
Ruggiero FM et al. | Membrane binding, endocytic trafficking and intracellular fate of high-affinity antibodies to gangliosides GD1a and GM1. | 2017 | Biochim. Biophys. Acta | pmid:27806911 |
Ryu YS et al. | Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes. | 2016 | Sci Rep | pmid:27230411 |
Patel DS et al. | Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature. | 2016 | Biophys. J. | pmid:27806280 |
Takehara M et al. | Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils. | 2016 | Biol. Pharm. Bull. | pmid:27725448 |
Przybylska-FeluÅ› M et al. | Concentrations of antiganglioside M1 antibodies, neuron-specific enolase, and interleukin 10 as potential markers of autonomic nervous system impairment in celiac disease. | 2016 | Pol. Arch. Med. Wewn. | pmid:27545437 |
Drolez A et al. | ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier. | 2016 | Int J Mol Sci | pmid:27529215 |
Marcon RM et al. | Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations. | 2016 | Clinics (Sao Paulo) | pmid:27438570 |
Bragiel AM et al. | Mechanisms Underlying Activation of αâ‚-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions. | 2016 | Int J Mol Sci | pmid:27367668 |
Kuhlmann FM et al. | Blood Group O-Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27162272 |
Yeh SC et al. | Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27143722 |
Worstell NC et al. | Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array. | 2016 | PLoS ONE | pmid:27070150 |
Kohyama M et al. | In situ detection of GM1 and GM2 gangliosides using immunohistochemical and immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses. | 2016 | BMC Vet. Res. | pmid:27036194 |
Luo Y et al. | Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation. | 2016 | MBio | pmid:27006465 |
Leri M et al. | Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin. | 2016 | J. Cell. Mol. Med. | pmid:26990223 |
Madhavan TP et al. | Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE. | 2016 | Infect. Immun. | pmid:26975993 |
Friedrich RP et al. | Novel nanoparticulate drug delivery systems. | 2016 | Nanomedicine (Lond) | pmid:26911384 |
Zhao L et al. | Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. | 2016 | Virology | pmid:26901486 |
Eich C et al. | Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters. | 2016 | Sci Rep | pmid:26869100 |
Kim JW et al. | Ganglioside GD1a promotes oocyte maturation, furthers preimplantation development, and increases blastocyst quality in pigs. | 2016 | J. Reprod. Dev. | pmid:26860251 |
Lardone RD et al. | Individual Restriction Of Fine Specificity Variability In Anti-GM1 IgG Antibodies Associated With Guillain-Barré Syndrome. | 2016 | Sci Rep | pmid:26818965 |
Li L et al. | Protection against Experimental Stroke by Ganglioside GM1 Is Associated with the Inhibition of Autophagy. | 2016 | PLoS ONE | pmid:26751695 |
Calamai M et al. | Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers. | 2016 | Biochim. Biophys. Acta | pmid:26656159 |
Wu G et al. | Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca²⺠influx. | 2016 | J. Neurochem. | pmid:26526326 |
Tsai YT et al. | GM1 Ganglioside is Involved in Epigenetic Activation Loci of Neuronal Cells. | 2016 | Neurochem. Res. | pmid:26498762 |
Thomaier M et al. | High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs. | 2016 | Biochemistry | pmid:27933798 |
Yu RK et al. | Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro. | 2016 | Glycobiology | pmid:26405107 |
Li-Mao YJ et al. | Monosialotetrahexosylganglioside protect cerebral ischemia/reperfusion injury through upregulating the expression of tyrosine hydroxylase by inhibiting lipid peroxidation. | 2016 | Biomed. Pharmacother. | pmid:27847214 |
Sridhar A et al. | Multi-scale molecular dynamics study of cholera pentamer binding to a GM1-phospholipid membrane. | 2016 | J. Mol. Graph. Model. | pmid:27474868 |
Liang Y et al. | The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells. | 2016 | Cell Biochem. Funct. | pmid:27558076 |
Ando K et al. | Nanometric Gap Structure with a Fluid Lipid Bilayer for the Selective Transport and Detection of Biological Molecules. | 2016 | Langmuir | pmid:27427950 |
Van Blerkom J and Zimmermann S | Ganglioside-enriched microdomains define an oolemma that is functionally polarized with respect to fertilizability in the mouse. | 2016 | Reprod. Biomed. Online | pmid:27515228 |
Oropesa-Nuñez R et al. | Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy. | 2016 | Oncotarget | pmid:27391440 |
Hung JT et al. | Design, Synthesis, and Biological Evaluation of Ganglioside Hp-s1 Analogues Varying at Glucosyl Moiety. | 2016 | ACS Chem Neurosci | pmid:27276519 |
Liao B et al. | Alternating ptosis associated with asialo-GM1 and GD1b antibodies. | 2016 | Int. J. Neurosci. | pmid:26710925 |
Cohen R et al. | Lipid Regulation of Acrosome Exocytosis. | 2016 | Adv Anat Embryol Cell Biol | pmid:27194352 |
Lee D et al. | Unilateral isolated oculomotor nerve palsy with antibodies to GM1 ganglioside. | 2016 | Neurol. Sci. | pmid:27166708 |
Harschnitz O et al. | Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. | 2016 | Ann. Neurol. | pmid:27130524 |
Liu D et al. | An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury. | 2016 | Adv Healthc Mater | pmid:27113454 |
Kasimov MR et al. | Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction. | 2016 | Biochim. Biophys. Acta | pmid:27102612 |
Bhuiyan RH et al. | Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes. | 2016 | Glycobiology | pmid:27102283 |
Ni YF et al. | GM1 ganglioside reverses the cognitive deficits induced by MK801 in mice. | 2016 | Behav Pharmacol | pmid:26960162 |
Haroon MM et al. | A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain. | 2016 | J Control Release | pmid:26948382 |
He B et al. | Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis. | 2016 | Nanoscale | pmid:26932537 |
Blaum BS et al. | Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations. | 2016 | Glycobiology | pmid:26715202 |
Zhang X et al. | Abnormal lipid rafts related ganglioside expression and signaling in T lymphocytes in immune thrombocytopenia patients. | 2016 | Autoimmunity | pmid:26287565 |
Nicastro MC et al. | Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains. | 2016 | Biophys. Chem. | pmid:26259785 |
Abd-Elhadi S et al. | Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA. | 2016 | Anal Bioanal Chem | pmid:27624766 |
Aureli M et al. | GM1 Ganglioside: Past Studies and Future Potential. | 2016 | Mol. Neurobiol. | pmid:25762012 |
Ba XH | Therapeutic effects of GM1 on Parkinson's disease in rats and its mechanism. | 2016 | Int. J. Neurosci. | pmid:25495991 |
Ji S et al. | Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27644882 |
Ishigaki H et al. | Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AÂ Case Report and Review of the Literature. | 2016 | Pediatr. Neurol. | pmid:27400822 |
Fricke N and Dimova R | GM1 Softens POPC Membranes and Induces the Formation of Micron-Sized Domains. | 2016 | Biophys. J. | pmid:27806275 |
Prasanna X et al. | The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain. | 2016 | Biochim. Biophys. Acta | pmid:27552916 |
Evangelisti E et al. | Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases. | 2016 | Sci Rep | pmid:27619987 |
Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
Ling ZM et al. | Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT. | 2015 | PLoS ONE | pmid:26010770 |
Leonhard V et al. | Biochemical characterization of the interactions between doxorubicin and lipidic GM1 micelles with or without paclitaxel loading. | 2015 | Int J Nanomedicine | pmid:26005348 |
Vandermeersch S et al. | Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V. | 2015 | Molecules | pmid:25913930 |
Takagishi T et al. | Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane. | 2015 | PLoS ONE | pmid:25910247 |
Koga M et al. | Complex of GM1- and GD1a-like lipo-oligosaccharide mimics GM1b, inducing anti-GM1b antibodies. | 2015 | PLoS ONE | pmid:25867522 |
Moens PD et al. | Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. | 2015 | Biophys. J. | pmid:25809257 |
Baldauf KJ et al. | Cholera toxin B: one subunit with many pharmaceutical applications. | 2015 | Toxins (Basel) | pmid:25802972 |
Basu I and Mukhopadhyay C | In silico phase separation in the presence of GM1 in ternary and quaternary lipid bilayers. | 2015 | Phys Chem Chem Phys | pmid:26067631 |
Ledeen RW and Wu G | The multi-tasked life of GM1 ganglioside, a true factotum of nature. | 2015 | Trends Biochem. Sci. | pmid:26024958 |
Phongsisay V et al. | Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors. | 2015 | Mol. Immunol. | pmid:26021803 |
Sato S et al. | A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26015171 |
Zhang J et al. | The Possible Damaged Mechanism and the Preventive Effect of Monosialotetrahexosylganglioside in a Rat Model of Cerebral Ischemia-Reperfusion Injury. | 2015 | J Stroke Cerebrovasc Dis | pmid:25934141 |
Yagi-Utsumi M and Kato K | Structural and dynamic views of GM1 ganglioside. | 2015 | Glycoconj. J. | pmid:25931034 |
Sasahara K et al. | Uptake of raft components into amyloid β-peptide aggregates and membrane damage. | 2015 | Anal. Biochem. | pmid:25908557 |
Yanagisawa K | GM1 ganglioside and Alzheimer's disease. | 2015 | Glycoconj. J. | pmid:25903682 |