Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GI?

Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ganglioside GI

MeSH term MeSH ID Detail
Gaucher Disease D005776 13 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GI

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GI?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ganglioside GI?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GI?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ganglioside GI?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GI?

Knock-out

Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).

Transgenic Model

Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).

Disease model

Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ganglioside GI

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Authors Title Published Journal PubMed Link
Takehara M et al. Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils. 2016 Biol. Pharm. Bull. pmid:27725448
Przybylska-FeluÅ› M et al. Concentrations of antiganglioside M1 antibodies, neuron-specific enolase, and interleukin 10 as potential markers of autonomic nervous system impairment in celiac disease. 2016 Pol. Arch. Med. Wewn. pmid:27545437
Drolez A et al. ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier. 2016 Int J Mol Sci pmid:27529215
Marcon RM et al. Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations. 2016 Clinics (Sao Paulo) pmid:27438570
Bragiel AM et al. Mechanisms Underlying Activation of α₁-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions. 2016 Int J Mol Sci pmid:27367668
Yu RK et al. Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro. 2016 Glycobiology pmid:26405107
He B et al. Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis. 2016 Nanoscale pmid:26932537
Blaum BS et al. Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations. 2016 Glycobiology pmid:26715202
Zhang X et al. Abnormal lipid rafts related ganglioside expression and signaling in T lymphocytes in immune thrombocytopenia patients. 2016 Autoimmunity pmid:26287565
Prasanna X et al. The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain. 2016 Biochim. Biophys. Acta pmid:27552916